Tanja Schwerdtle
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Interaction of serum zinc and copper status with fatty acid desaturases on incidence of type 2 diabetes in the EPIC-Potsdam study Open
Zn and Cu status modified the relationship between FA desaturases and T2D risk. This was supported by serum Zn and Cu levels and by genetic variation related to their transport and homeostasis.
Distribution interactions of the trace elements zinc, copper, and selenium under conditions of their parallel deficiency Open
Trace elements such as copper, zinc, and selenium are essential micronutrients that play crucial roles in various physiological processes, mainly through their involvement in enzymes and regulatory proteins. A deficiency of any of these el…
View article: Influence of copper level and source on performance, tissue accumulation, and faecal excretion in fattening pigs
Influence of copper level and source on performance, tissue accumulation, and faecal excretion in fattening pigs Open
Copper (Cu) supplementation is essential in pig nutrition; however, its effects on performance, trace element accumulation in edible tissues, and environmental excretion require careful evaluation. In the present study a total of 24 male, …
Trace Elements and Genomic Instability in the Murine Brain Open
The trace elements copper, iron, manganese, selenium and zinc are essential micronutrients involved in various cellular processes, all with different responsibilities. Based on that importance, their concentrations are tightly regulated in…
Accumulation of per- and polyfluoroalkyl substances (PFAS) in tissues of wild boar (Sus scrofa) Open
The widespread application of per- and polyfluoroalkyl substances (PFAS) resulted in ubiquitous environmental contamination. Understanding the PFAS tissue distribution in mammals and humans is crucial for the assessment of potential health…
Improving the selenium supply of vegans and omnivores with Brazil nut butter compared to a dietary supplement in a randomized controlled trial Open
Purpose A vegan diet is associated with health benefits but may also lead to inadequate intake of essential nutrients. Due to the lower selenium content in plant-based compared to animal-based foods, many vegans do not reach the recommende…
View article: Cellular mechanisms of copper neurotoxicity in human, differentiated neurons
Cellular mechanisms of copper neurotoxicity in human, differentiated neurons Open
Copper (Cu) is an essential trace element involved in fundamental physiological processes in the human body. Even slight disturbances in the physiological Cu homeostasis are associated with the manifestation of neurodegenerative diseases. …
View article: Risk assessment of complex organoarsenic species in food
Risk assessment of complex organoarsenic species in food Open
The European Commission asked EFSA for a risk assessment on complex organoarsenic species in food. They are typically found in marine foods and comprise mainly arsenobetaine (AsB), arsenosugars and arsenolipids. For AsB, no reference point…
View article: Conceptual basis for the development of guidance for the use of biomarkers of effect in regulatory risk assessment of chemicals
Conceptual basis for the development of guidance for the use of biomarkers of effect in regulatory risk assessment of chemicals Open
This Scientific Report was carried out in the context of the self‐task mandate (M‐2023‐00097) of the EFSA's Scientific Committee on ‘Guidance on the use of biomarkers of effect in regulatory risk assessment of chemicals’. In the first phas…
View article: The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death
The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death Open
Accumulation of the age pigment lipofuscin represents a ubiquitous hallmark of the aging process. However, our knowledge about cellular effects of lipofuscin accumulation is potentially flawed, because previous research mainly utilized hig…
Dysfunctional copper homeostasis in Caenorhabditis elegans affects genomic and neuronal stability Open
While copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is cru…
View article: Genotoxicity of beauvericin
Genotoxicity of beauvericin Open
The European Commission (EC) asked EFSA to assess the genotoxicity of beauvericin (BEA). Relevant information, including that which has become available since the 2014 Scientific Opinion on the risks to human and animal health related to t…
Copper-mediated neurotoxicity and genetic vulnerability in the background of neurodegenerative diseases in <i>C. elegans</i> Open
The mechanisms associated with neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), have yet to be fully characterized, and genetic as well as environmental factors in their disease etiology are undera…
Annex G – Calculation of the combined margin of exposure (MOET) Open
This Annex contains the calculations of the combined margin of exposure (MOET) for the risk characterisation of PBDEs related to the Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.
Update of the scientific opinion on tetrabromobisphenol A (TBBPA) and its derivatives in food Open
The European Commission asked EFSA to update its 2011 risk assessment on tetrabromobisphenol A (TBBPA) and five derivatives in food. Neurotoxicity and carcinogenicity were considered as the critical effects of TBBPA in rodent studies. The …
View article: Risk assessment of small organoarsenic species in food
Risk assessment of small organoarsenic species in food Open
The European Commission asked EFSA for a risk assessment on small organoarsenic species in food. For monomethylarsonic acid MMA(V), decreased body weight resulting from diarrhoea in rats was identified as the critical endpoint and a BMDL10…
View article: Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death
Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death Open
Accumulation of the age pigment lipofuscin represents a ubiquitous hallmark of the aging process. However, our knowledge about cellular effects of lipofuscin accumulation is potentially flawed, because previous research mainly utilized hig…
Determination of copper status by five biomarkers in serum of healthy women Open
This study suggests that the non-CP-bound copper species represent copper pools that are differently regulated from total copper or CP-bound copper, making them interesting complementary biomarkers to enable a more complete assessment of b…
View article: Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food
Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food Open
EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN conge…
View article: Establishment of a nonradioactive <scp>DNA</scp> ligation assay and its applications in murine tissues
Establishment of a nonradioactive <span>DNA</span> ligation assay and its applications in murine tissues Open
As final process of every DNA repair pathway, DNA ligation is crucial for maintaining genomic stability and preventing DNA strand breaks to accumulate. Therefore, a method reliably assessing DNA ligation capacity in protein extracts from m…
View article: Postprandial Micronutrient Variability and Bioavailability: An Interventional Meal Study in Young vs. Old Participants
Postprandial Micronutrient Variability and Bioavailability: An Interventional Meal Study in Young vs. Old Participants Open
This study explores age- and time-dependent variations in postprandial micronutrient absorption after a micronutrient-rich intervention meal within the Biomiel (bioavailability of micronutrients in elderly) study. Comprising 43 healthy par…
Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans Open
Copper (Cu) is an essential trace element, however an excess is toxic due to its redox properties. Cu homeostasis therefore needs to be tightly regulated via cellular transporters, storage proteins and exporters. An imbalance in Cu homeost…
View article: Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum
Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum Open
The ageing process is associated with alterations of systemic trace element (TE) homeostasis increasing the risk, e.g. neurodegenerative diseases. Here, the impact of long-term modulation of dietary intake of copper, iron, selenium, and zi…
Annex F – Chronic dietary exposure to PBDEs and the contribution of different food groups to the dietary exposure Open
This Annex contains the chronic dietary exposure assessment to PBDEs per survey and the contribution of different food groups to the dietary exposure related to the Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in…