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View article: Surgical Management of Ovarian Masses in Children: A Comparative Analysis by Pediatric Surgeons and Gynecologists at Two Academic Hospitals in Johannesburg
Surgical Management of Ovarian Masses in Children: A Comparative Analysis by Pediatric Surgeons and Gynecologists at Two Academic Hospitals in Johannesburg Open
Background and Objectives Existing literature on ovarian masses necessitating intervention in children by pediatric surgeons and gynecologists in Low‐ and Middle‐Income Countries is sparse and lacks collaborative standardization in managem…
View article: Performance Assessment of a PV-Powered EV Charging Station Using Conventional and Enhanced MPPT Algorithms with Economic Feasibility Analysis
Performance Assessment of a PV-Powered EV Charging Station Using Conventional and Enhanced MPPT Algorithms with Economic Feasibility Analysis Open
As the world moves toward cleaner transportation solutions, photovoltaic (PV)-powered electric vehicle (EV) charging stations present a promising solution to reducing greenhouse gas emissions and relieving pressure on conventional power gr…
View article: Assessment of Genetic Variability, Heritability and Genetic Advance for Vegetative, Yield and Yield Component Traits in Tomato (Solanum lycopersicum L.) in Burkina Faso
Assessment of Genetic Variability, Heritability and Genetic Advance for Vegetative, Yield and Yield Component Traits in Tomato (Solanum lycopersicum L.) in Burkina Faso Open
In Burkina Faso, tomatoes have a significant portion in vegetable production and play a major socio-economic impact within rural populations. To meet the increased demand for fresh tomatoes, the development of improved tomato varieties is …
View article: Causes of death in adults living with HIV in South Africa: A single-centre postmortem study
Causes of death in adults living with HIV in South Africa: A single-centre postmortem study Open
Background: Mortality among people living with HIV (PLWH) in developing settings remains elevated, despite high coverage with antiretroviral therapy (ART), with 70% – 80% being virally suppressed (VS). Objectives: This study aimed to deter…
View article: Role of Reserve Cells in Metaplasia and the Development of Human Papillomavirus–Associated High-Grade Squamous Intraepithelial Lesions at the Cervical Transformation Zone
Role of Reserve Cells in Metaplasia and the Development of Human Papillomavirus–Associated High-Grade Squamous Intraepithelial Lesions at the Cervical Transformation Zone Open
Squamous cervical cancers generally arise as a result of persistent infection with high-risk human papillomaviruses (hrHPVs) and occur near the squamocolumnar junction (SCJ) and within the transformation zone (TZ). The susceptibility of th…
View article: Prolonged Diagnostic Interval Leads to High Lymphoma Related Mortality in a Prospective Cohort of People with HIV Undergoing Fine Needle Aspiration
Prolonged Diagnostic Interval Leads to High Lymphoma Related Mortality in a Prospective Cohort of People with HIV Undergoing Fine Needle Aspiration Open
Background: HIV is associated with an increased risk of aggressive lymphomas. Lymphadenopathy is common at the time of presentation; therefore, we set out to understand the time to lymphoma diagnosis in people with HIV (PWH) undergoing fin…
View article: Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review
Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review Open
View article: Steatotic liver disease in people with HIV at Tshepong Hospital: A post-mortem analysis
Steatotic liver disease in people with HIV at Tshepong Hospital: A post-mortem analysis Open
Background: Liver disease is the leading cause of non-AIDS-related mortality in people living with HIV (PLWH). Steatotic liver disease (SLD) is increasingly recognised as an important aetiological factor in liver dysfunction in PLWH.Object…
View article: Real-world treatment outcomes for Hodgkin lymphoma in South Africa: a prospective observational study
Real-world treatment outcomes for Hodgkin lymphoma in South Africa: a prospective observational study Open
Background Prospective data from sub-Saharan Africa suggests that treatment outcomes for people living with HIV (PWH) with Hodgkin lymphoma (HL) are similar to those without HIV. However, real-world data from high-resource settings and ret…
View article: Sources of Diagnostic Delay for HIV-Associated Lymphoma in a Fine Needle Aspiration Clinic in Soweto, South Africa
Sources of Diagnostic Delay for HIV-Associated Lymphoma in a Fine Needle Aspiration Clinic in Soweto, South Africa Open
PURPOSE Fine needle aspiration (FNA) is an important diagnostic modality used in the evaluation of lymphadenopathy in people living with HIV (PWH) to differentiate between tuberculosis (TB) and lymphoma. However, an FNA suggestive of lymph…
View article: A randomized clinical trial comparing cervical dysplasia treatment with cryotherapy vs loop electrosurgical excision procedure in HIV-seropositive women from Johannesburg, South Africa
A randomized clinical trial comparing cervical dysplasia treatment with cryotherapy vs loop electrosurgical excision procedure in HIV-seropositive women from Johannesburg, South Africa Open
Background Mortality associated with cervical cancer is a public health concern for women, particularly in HIV–seropositive women in resource-limited countries. HIV-seropositive women are at a higher risk of high-grade cervical precancer, …
View article: P029 Loss of adipose tissue protects mice from intestinal inflammation
P029 Loss of adipose tissue protects mice from intestinal inflammation Open
Background Crohn’s disease (CD) is associated with creeping fat, characterized by hyperplasia of mesenteric adipocytes and increased secretion of various adipokines, including leptin. Leptin can promote intestinal inflammation by inducing …
View article: Real-World Treatment Outcomes for Hodgkin Lymphoma in South Africa: A Prospective Observational Study
Real-World Treatment Outcomes for Hodgkin Lymphoma in South Africa: A Prospective Observational Study Open
View article: Undiagnosed Pulmonary Tuberculosis (TB) and Coronavirus Disease 2019 (COVID-19) in Adults Dying at Home in a High-TB-Burden Setting, Before and During Pandemic COVID-19: An Autopsy Study
Undiagnosed Pulmonary Tuberculosis (TB) and Coronavirus Disease 2019 (COVID-19) in Adults Dying at Home in a High-TB-Burden Setting, Before and During Pandemic COVID-19: An Autopsy Study Open
Background Missing or undiagnosed patients with tuberculosis (TB) or coronavirus disease 2019 (COVID-19) are of concern. Identifying both infections in patients with no diagnosis prior to death contributes to understanding the burden of di…
View article: Significance of lymph node fine needle aspiration for the diagnosis of HIV-associated lymphoma in a low-resource setting
Significance of lymph node fine needle aspiration for the diagnosis of HIV-associated lymphoma in a low-resource setting Open
Objective: Fine needle aspiration (FNA) is an early step in the work-up of lymphadenopathy in people with HIV (PWH). We set out to characterize the FNA cytology in PWH and report on the time to lymphoma diagnosis through the FNA clinics in…
View article: Feasibility of Cell-Free DNA Collection and Clonal Immunoglobulin Sequencing in South African Patients With HIV-Associated Lymphoma
Feasibility of Cell-Free DNA Collection and Clonal Immunoglobulin Sequencing in South African Patients With HIV-Associated Lymphoma Open
PURPOSE Diagnosis of AIDS lymphoma in low-resource settings, like South Africa, is often delayed, leaving patients with limited treatment options. In tuberculosis (TB) endemic regions, overlapping signs and symptoms often lead to diagnosti…
View article: Diagnostic accuracy of cervical cancer screening and screening–triage strategies among women living with HIV-1 in Burkina Faso and South Africa: A cohort study
Diagnostic accuracy of cervical cancer screening and screening–triage strategies among women living with HIV-1 in Burkina Faso and South Africa: A cohort study Open
Background Cervical cancer screening strategies using visual inspection or cytology may have suboptimal diagnostic accuracy for detection of precancer in women living with HIV (WLHIV). The optimal screen and screen–triage strategy, age to …
View article: Validation of Cervical Cancer Screening Methods in HIV Positive Women from Johannesburg South Africa
Validation of Cervical Cancer Screening Methods in HIV Positive Women from Johannesburg South Africa Open
BackgroundHIV-infected women are at increased risk for developing cervical cancer. Women living in resource-limited countries are especially at risk due to poor access to cervical cancer screening and treatment. We evaluated three cervical…
View article: Prospective One Year Follow Up of HIV Infected Women Screened for Cervical Cancer Using Visual Inspection with Acetic Acid, Cytology and Human Papillomavirus Testing in Johannesburg South Africa
Prospective One Year Follow Up of HIV Infected Women Screened for Cervical Cancer Using Visual Inspection with Acetic Acid, Cytology and Human Papillomavirus Testing in Johannesburg South Africa Open
BackgroundCervical cancer is the most common cancer in Sub-Saharan Africa. There are little of HIV-infected women one-year after screening using visual inspection with acetic acid (VIA), HPV or cytology in sub-Saharan Africa.MethodsHIV-inf…
View article: Lessons learnt conducting minimally invasive autopsies in private mortuaries as part of HIV and tuberculosis research in South Africa
Lessons learnt conducting minimally invasive autopsies in private mortuaries as part of HIV and tuberculosis research in South Africa Open
Current estimates of the burden of tuberculosis (TB) disease and cause-specific mortality in human immunodeficiency virus (HIV) positive people rely heavily on indirect methods that are less reliable for ascertaining individual-level cause…
View article: Human papillomavirus infection and cervical dysplasia in HIV-positive women
Human papillomavirus infection and cervical dysplasia in HIV-positive women Open
hrHPV infection (and/or increased sexual risk-taking) may cause anaerobic vaginal dysbiosis, but a bidirectional relationship is also possible. In this population, dysbiosis did not increase CIN2+ risk, but CIN2+ increased dysbiosis risk. …
View article: An observational study of safe and risky practices in funeral homes in South Africa
An observational study of safe and risky practices in funeral homes in South Africa Open
There is a need to standardise the use of safety equipment, waste disposal methods and location designation in the funeral industry.
View article: Cryptococcal-related Mortality Despite Fluconazole Preemptive Treatment in a Cryptococcal Antigen Screen-and-Treat Program
Cryptococcal-related Mortality Despite Fluconazole Preemptive Treatment in a Cryptococcal Antigen Screen-and-Treat Program Open
Background Cryptococcal antigen (CrAg) screening and treatment with preemptive fluconazole reduces the incidence of clinically evident cryptococcal meningitis in individuals living with advanced human immunodeficiency virus (HIV) disease. …
View article: Prevalence and Antimicrobial Resistance of Mycoplasma genitalium Infection Among Women Living With Human Immunodeficiency Virus in South Africa: A Prospective Cohort Study
Prevalence and Antimicrobial Resistance of Mycoplasma genitalium Infection Among Women Living With Human Immunodeficiency Virus in South Africa: A Prospective Cohort Study Open
This prospective cohort study of 622 women living with human immunodeficiency virus (HIV) from Johannesburg (2012) detected Mycoplasma genitalium in 7.4% (95% confidence interval [CI]: 5.5–9.7, 46/622), with detection more likely with lowe…
View article: Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis
Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis Open
UK Medical Research Council.
View article: High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients
High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients Open
About a third of asymptomatic CrAg-positive patients have concurrent cryptococcal meningitis. More effective clinical assessment strategies and antifungal regimens are required for CrAg-positive patients, including investigation for crypto…
View article: Molecular Diagnostics for AIDS Lymphoma Diagnosis in South Africa and the Potential for Other Low- and Middle-Income Countries
Molecular Diagnostics for AIDS Lymphoma Diagnosis in South Africa and the Potential for Other Low- and Middle-Income Countries Open
View article: Table of Contents
Table of Contents Open
View article: Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa
Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa Open
HR-HPV persistence is very common among African WLHIV and is linked to incident CIN2+. HPV vaccines could prevent between 37-90% of CIN2+ among African WLHIV.
View article: Measuring mortality due to HIV-associated tuberculosis among adults in South Africa: Comparing verbal autopsy, minimally-invasive autopsy, and research data
Measuring mortality due to HIV-associated tuberculosis among adults in South Africa: Comparing verbal autopsy, minimally-invasive autopsy, and research data Open
Current VA methods underestimate mortality due to HIV-associated TB. ICD and VA methods need modifications that allow for more specific evaluation of HIV-related deaths and direct estimation of mortality due to HIV-associated TB.