Tanya C. Burch
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View article: Increased α2,3‐sialyl N‐glycosylated prostate‐specific membrane antigen (PSMA) in post‐DRE urine is associated with high grade group prostate cancer
Increased α2,3‐sialyl N‐glycosylated prostate‐specific membrane antigen (PSMA) in post‐DRE urine is associated with high grade group prostate cancer Open
INTRODUCTION: Aberrant glycosylation of proteins is an important hallmark in multiple cancers. Prostate-specific membrane antigen (PSMA), a highly glycosylated protein with 10 N-linked glycosylation sites, is an Food and Drug Administratio…
View article: Proteomic and mass spectrometry-based identification of viral proteins in human tissue samples from the Network for Pancreatic Organ Donors with Diabetes
Proteomic and mass spectrometry-based identification of viral proteins in human tissue samples from the Network for Pancreatic Organ Donors with Diabetes Open
Aims/Hypothesis Multiple studies associated enterovirus (EV) infections with type 1 diabetes. The Network for Pancreatic Organ Donors with Diabetes (nPOD) obtained samples from organ donors with/without type 1 diabetes and launched the nPO…
View article: Increased α2,3‐sialyl N‐glycosylated prostate‐specific membrane antigen (PSMA) in post‐DRE urine is associated with high grade group prostate cancer
Increased α2,3‐sialyl N‐glycosylated prostate‐specific membrane antigen (PSMA) in post‐DRE urine is associated with high grade group prostate cancer Open
Introduction Aberrant glycosylation of proteins is an important hallmark in multiple cancers. Prostate‐specific membrane antigen (PSMA), a highly glycosylated protein with 10 N‐linked glycosylation sites, is an Food and Drug Administration…
View article: Prostate‐specific membrane antigen (PSMA) glycoforms in prostate cancer patients seminal plasma
Prostate‐specific membrane antigen (PSMA) glycoforms in prostate cancer patients seminal plasma Open
Introduction Prostate‐specific membrane antigen (PSMA) is a US Food and Drug Administration‐approved theranostic target for prostate cancer (PCa). Although PSMA is known to be glycosylated, the composition and functional roles of its N‐lin…
View article: NEFL is overexpressed and it modulates invasion and migration in neuroendocrine-like PC3-ML2 prostate cancer cells
NEFL is overexpressed and it modulates invasion and migration in neuroendocrine-like PC3-ML2 prostate cancer cells Open
Prostate cancer (PCa) is the most common cancer in men in USA. For the year 2022, current estimates predict the diagnosis of 268,490 new cases and 34,500 deaths in the country (Siegel et al., 2022) Prostate cancer has diverse disease patho…
View article: Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells
Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells Open
The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized. PSMA was isolated from two metasta…
View article: Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate
Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate Open
Heparan sulfate (HS) 6-O-endosulfatase (Sulf) catalyzes the hydrolysis of 6-O-sulfo groups from HS polysaccharides. The resultant HS has reduced sulfation levels and displays altered biological activities. The Sulfs have been associated wi…
View article: Biochemical Characterization of Human Heparan Sulfate 6-O-Endosulfatase
Biochemical Characterization of Human Heparan Sulfate 6-O-Endosulfatase Open
Heparan sulfate (HS) is a complex and diverse polysaccharide abundantly found on the cell surface of cells from several different species. The HS biosynthetic machinery creates very heterogeneous structures that interact with a variety of …
View article: Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes
Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes Open
Type 1 diabetes (T1D) is a chronic inflammatory disease that is characterized by autoimmune destruction of insulin-producing pancreatic beta cells. The goal of this study was to identify novel protein signatures that distinguish Islets fro…
View article: Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes
Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes Open
Background. The most significant hallmarks of cancer are directly or indirectly linked to deregulated mitochondria. In this study, we sought to profile mitochondria associated genes in isogenic prostate cell lines with different tumorigeni…