Tanya Prasolava
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View article: Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence
Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence Open
Huntington disease (HD) is caused by inherited CAG expansions, which continue expanding somatically in affected brain regions to hasten disease onset and progression. Therapeutically diminishing somatic expansions is expected to be clinica…
View article: <i>C9orf72</i>expansion creates the unstable folate-sensitive fragile site FRA9A
<i>C9orf72</i>expansion creates the unstable folate-sensitive fragile site FRA9A Open
The hyper-unstable Chr9p21 locus, harbouring the interferon gene cluster, oncogenes and C9orf72, is linked to multiple diseases. C9orf72 (GGGGCC)n expansions ( C9orf72 Exp) are associated with incompletely penetrant amyotrophic lateral scl…
View article: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability Open
View article: Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases
Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases Open
Tandem CAG repeat expansion mutations cause >15 neurodegenerative diseases, where ongoing expansions in patients’ brains are thought to drive disease onset and progression. Repeat length mutations will involve single-stranded DNAs prone to…
View article: Genome-wide detection of tandem DNA repeats that are expanded in autism
Genome-wide detection of tandem DNA repeats that are expanded in autism Open
View article: A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo Open