Taseer Ahmed Khan
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View article: Integrating Simulation-Based Learning in Clinical Skills Training: Impact on Medical Student Competency
Integrating Simulation-Based Learning in Clinical Skills Training: Impact on Medical Student Competency Open
Background: Simulation-based learning (SBL) is a new and innovative approach that improves the clinical skills of medical students by allowing standardized training and immediate feedback in comparison to existing methods. The purpose of t…
View article: From waste to shelf life: Olive pomace extract as a natural preservative for mangoes
From waste to shelf life: Olive pomace extract as a natural preservative for mangoes Open
The escalating challenge of agricultural and industrial waste, exemplified by olive pomace (OP), presents a unique opportunity to recover valuable bioactive compounds. This study pioneers a sustainable solution by transforming OP extract (…
View article: (131) A STUDY ON HORMONAL REPLACEMENT THERAPY IN LATE POSTMENOPAUSAL WOMEN
(131) A STUDY ON HORMONAL REPLACEMENT THERAPY IN LATE POSTMENOPAUSAL WOMEN Open
Introduction In our two medical centers, over 50% of peri-menopausal and menopausal women seeking care exceed the typical 10-year window for hormone replacement therapy (HRT) initiation or are over 60 years old. Many remain fully symptomat…
View article: Antioxidants and Antidiabetic Potential of Polyphenolic Fractions and Crude Extracts of <i>Rhus typhina</i> Fruit, <i>Punica granatum</i> L. Peel, and <i>Terminalia catappa</i> L. Leaves: In Vitro and In Vivo Evaluation
Antioxidants and Antidiabetic Potential of Polyphenolic Fractions and Crude Extracts of <i>Rhus typhina</i> Fruit, <i>Punica granatum</i> L. Peel, and <i>Terminalia catappa</i> L. Leaves: In Vitro and In Vivo Evaluation Open
Rhus typhina (sumac) fruit, Punica granatum (pomegranate) peel, and Terminalia catappa (Indian almond) leaves’ extracts and their anthocyanin and non‐anthocyanin fractions were assessed in vitro for 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) rad…
View article: Healthiness of Meat-Based Products in Comparison to Their Plant-Based Alternatives in the UK Market: A Packaging Evaluation
Healthiness of Meat-Based Products in Comparison to Their Plant-Based Alternatives in the UK Market: A Packaging Evaluation Open
This study evaluated the healthiness of meat products (n = 62) and their plant-based (PB) counterparts (n = 62) available in the UK market. Back-of-pack (BoP) and front-of-pack (FoP) nutrition label information, nutrition and health claims…
View article: Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population: a case control study
Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population: a case control study Open
In recent years, the global prevalence of obesity and its associated metabolic disorders has reached alarming levels, presenting a significant challenge to public health worldwide. Visfatin, also known as pre-B cell colony-enhancing factor…
View article: Association of Circulating Spexin Levels with Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Women and Normal Controls
Association of Circulating Spexin Levels with Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Women and Normal Controls Open
Objective: To evaluate and compare theserum Spexin levels in women with and without polycystic ovary syndrome (PCOS) and to find if there is any association of Spexin levels with metabolic and hormonal parameters among PCOS women. Methods:…
View article: Advances in sensing for real-time monitoring of tribological parameters
Advances in sensing for real-time monitoring of tribological parameters Open
The wider availability of low-cost sensing and data acquisition technologies means that real-time sensing of tribological parameters is becoming increasingly viable. Consequently, the potential to use these technologies to monitor in-servi…
View article: Country Level Governance as A Capital Structure Determinant: A Case of Pakistani Non-Financial Listed Firms
Country Level Governance as A Capital Structure Determinant: A Case of Pakistani Non-Financial Listed Firms Open
Current paper investigated the effects of country governance indicators and firm level variables on the capital structure of non-financial listed firms registered with Pakistan Stock Exchange (PSX) for the interval of 2002-18. The collecte…
View article: Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population; a case control study
Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population; a case control study Open
The metabolic syndrome is a group of factors including central obesity, dyslipidemia, hypertension, and impaired glucose tolerance, with obesity being the most significant aspect. The influence of gene variants involved in hormone synthesi…
View article: GENETIC RISK FOR BREAST CANCER DEVELOPMENT
GENETIC RISK FOR BREAST CANCER DEVELOPMENT Open
Objective: studies in the relation of moderate risk susceptibility genes in the onset of breast ca Methods: Systematic random samples are done on selected Breast cancer patients from tertiary care hospitals in Karachi. The sample size was …
View article: Associations of vitamin D receptor encoding gene variants with premenopausal breast cancer risk
Associations of vitamin D receptor encoding gene variants with premenopausal breast cancer risk Open
Objective This study evaluates whether vitamin D receptor (VDR) gene variations are associated with premenopausal breast cancer in Pakistani cohorts. Methods Genomic DNA was isolated from 228 breast cancer patients and 500 non‐cancer contr…
View article: A STUDY ON MORPHOMETRIC, HAEMATOLOGICAL, AND FEEDING ANALYSIS OF BAYA WEAVER (PLOCEUS PHILIPPINUS) FROM PAKISTAN
A STUDY ON MORPHOMETRIC, HAEMATOLOGICAL, AND FEEDING ANALYSIS OF BAYA WEAVER (PLOCEUS PHILIPPINUS) FROM PAKISTAN Open
Baya weaver is found in floodplains of Pakistan and is famous for building retort shaped hanging nests. For this study, 24 samples of baya weaver (twelve from both sexes) were collected from the wild habitat to analyze morphometry, haemato…
View article: Serum Ace and Ace I/D Polymorphism: Risk of Type 2 Diabetes with and Without Nephropathy in Pakistani Cohort
Serum Ace and Ace I/D Polymorphism: Risk of Type 2 Diabetes with and Without Nephropathy in Pakistani Cohort Open
Objective: To find serum ACE (Angiotensin converting enzyme) level and the role of ACE I/D polymorphism with T2DM (Type 2 Diabetes Mellitus) among the Pakistani cohort.
Methods: A total of 110 diagnosed T2DM patients and 100 normotensive …
View article: Association of promoter region A-1012G polymorphism (rs4516035) of vitamin-D receptor gene with coronary artery disease
Association of promoter region A-1012G polymorphism (rs4516035) of vitamin-D receptor gene with coronary artery disease Open
Objective: To investigate the correlation of Adenine-1012-Guanine (rs4516035) promoter region polymorphism of vitamin-D receptor gene with serum levels of omentin-1, vitamin-D and vitamin-D receptor protein in patients with coronary artery…
View article: Divalent Metal Ions; Key factor towards Pulmonary Tuberculosis
Divalent Metal Ions; Key factor towards Pulmonary Tuberculosis Open
Introduction: In tuberculosis disease infection, trace elements perform a significant role as their insufficiencies may be related to weakened immunity. The purpose of this study was to compare demographic profile and divalent metal Ions i…
View article: NDM Production as a Dominant Feature in Carbapenem-Resistant Enterobacteriaceae Isolates from a Tertiary Care Hospital
NDM Production as a Dominant Feature in Carbapenem-Resistant Enterobacteriaceae Isolates from a Tertiary Care Hospital Open
The worldwide spread and increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is of utmost concern and a problem for public health. This resistance is mainly conferred by carbapenemase production. Such strains are a poten…
View article: Sesquiterpene from Polygonum Barbatum Disrupt Mitochondrial Membrane Potential to Induce Apoptosis and Inhibits Metastasis by Downregulating Matrix Metalloproteinase and Osteopontin in NCI-H460 Cells
Sesquiterpene from Polygonum Barbatum Disrupt Mitochondrial Membrane Potential to Induce Apoptosis and Inhibits Metastasis by Downregulating Matrix Metalloproteinase and Osteopontin in NCI-H460 Cells Open
Background: Globally, lung cancer accounts for 18% of cancer-associated mortalities. Among the subtypes, non-small-cell lung cancer (NSCLC) is the most prevalent one. The increased resistance and poor survival rates, signifies disease aggr…
View article: Comparisons of open boundary conditions in a barotropic model of the northern Arabian Sea
Comparisons of open boundary conditions in a barotropic model of the northern Arabian Sea Open
These simulations are focused on the sensitivity of the barotropic ocean non-linear model to the various open boundary conditions (OBCs). Different OBCs from gradient to radiation condition are examined to determine the best result and hel…
View article: Relationship between El Nino and summer monsoon rainfall over Pakistan
Relationship between El Nino and summer monsoon rainfall over Pakistan Open
The present paper deals with the influence of El Nino event on the summer monsoon rainfall over Pakistan. The correlation between monthly rainfall of summer monsoon season and bi-Monthly Multivariate ENSO Index (MEI) has been calculated to…
View article: Interplay between oxidative stress, SIRT1, reproductive and metabolic functions
Interplay between oxidative stress, SIRT1, reproductive and metabolic functions Open
Silent information Regulators (SIRT1) gene stimulates antioxidants' expression, repairs cells damaged by oxidative stress (OS), and prevents the cells' dysfunction. In particular, the role of different Sirtuins, particularly SIRT1 in repro…
View article: Association of BDNF and SERT gene polymorphisms with depression among Pakistani population.
Association of BDNF and SERT gene polymorphisms with depression among Pakistani population. Open
Brain-derived neurotrophic factor (BDNF) and serotonin transporter (SERT) is implicated in the adverse life events which lead to depression. The variation in genetic make-up of BDNF (Val66Met) and SERT (5'-HTTLPR) are potential biomarkers …
View article: Genetic Variations of Brain Derived Neurotropic Factor Gene With Premenstrual Syndrome Among Pakistani Menarcheal Girls: A Pilot Study
Genetic Variations of Brain Derived Neurotropic Factor Gene With Premenstrual Syndrome Among Pakistani Menarcheal Girls: A Pilot Study Open
The premenstrual syndrome (PMS) comprises various physical and emotional symptoms which are associated with the menstrual cycle. The emotional changes might be due to the variation in the levels of BDNF especially lower levels of plasma BD…
View article: SIRT1 Gene Single Nucleotide Polymorphisms and Female Infertility: A Cross Sectional Study In Pakistan
SIRT1 Gene Single Nucleotide Polymorphisms and Female Infertility: A Cross Sectional Study In Pakistan Open
Aim & Objective: Silent information Regulators (SIRT1) gene stimulates the expression of antioxidants and repairs damaged cells. It affects the mitochondrial activity within the oocytes to overcome the oxidant stress. We aimed to assess an…
View article: SIRTI and cortisol in unexplained infertile females; a cross sectional study, in Karachi Pakistan
SIRTI and cortisol in unexplained infertile females; a cross sectional study, in Karachi Pakistan Open
View article: Antimicrobial role of Lactobacillus species as potential probiotics against enteropathogenic bacteria in chickens
Antimicrobial role of Lactobacillus species as potential probiotics against enteropathogenic bacteria in chickens Open
Introduction: The emergence of antimicrobial resistance among bacterial community resulted in a ban on drugs as the growth promoter in poultry feed. This situation demands to explore alternatives as food supplements with health benefit to …
View article: A Functional Polymorphism (rs6265, G>A) of Brain-Derived Neurotrophic Factor Gene and Breast Cancer: An Association Study
A Functional Polymorphism (rs6265, G>A) of Brain-Derived Neurotrophic Factor Gene and Breast Cancer: An Association Study Open
Purpose: The objective of this study was to evaluate the relationship between brain-derived neurotrophic factor (BDNF) gene (Val66Met, rs6265, G>A) polymorphism and breast cancer (BC) among females of Southern Pakistan. Methods: This case-…
View article: Bacteremia in a human caused by an XDR strain of Pseudomonas fulva
Bacteremia in a human caused by an XDR strain of Pseudomonas fulva Open
This is the first report from Pakistan of a case of bacteremia in a human due to P. fulva, an opportunistic infection with increased risk of a drug resistant phenotype. P. fulva was isolated from blood of a 45 years male admitted in surgic…
View article: Association of low penetrance vitamin D receptor <i>Tru</i>9I (rs757343) gene polymorphism with risk of premenopausal breast cancer
Association of low penetrance vitamin D receptor <i>Tru</i>9I (rs757343) gene polymorphism with risk of premenopausal breast cancer Open
Objective The aim of this study was to determine whether a novel polymorphism ( Tru9I) in the low penetrance vitamin D receptor (VDR) gene is associated with risk of premenopausal breast cancer (BC). Methods This case-control study include…
View article: Molecular characterization of universal Mycoplasma and Acholeplasma laidlawii from buffaloes (Bubalus bubalis) at Karachi, Pakistan.
Molecular characterization of universal Mycoplasma and Acholeplasma laidlawii from buffaloes (Bubalus bubalis) at Karachi, Pakistan. Open
The present study was conducted to identify and characterize the bovine Acholeplasma laidlawii from 1120 clinically ill buffaloes and 470 lungs collected from buffaloes at abattoir of Karachi. All buffaloes were clinically examined and aro…