Explanipedia

Three-dimensional Quantitative Structure–activity Relationship, Molecular Docking and Absorption, Distribution, Metabolism, and Excretion Studies of Lidocaine Analogs Pertaining to Voltage-gated Sodium Channel Nav1.7 Inhibition for the Management of Neuropathic Pain Open

Shiwani Sharma, Priyanka Rana, Neelima Dhingra, Tanzeer Kaur · 2025

Aim: This study aims to design and develop novel lidocaine analogs specific for the Na v 1.7 channel using in silico approaches. Background: Neuropathic pain (NP) is defined as chronic pain originating from abnormalities found within the n…

3D-QSAR, Molecular Docking and ADME Studies on Indole Analogues Reveal Antidepressant Activity Through Monoamine Oxidase-A Inhibition Open

Alka Kumari, Harnoor Kaur, Priyanka Rana, Tanzeer Kaur, Poonam Arora , et al. · 2023

Monoamine oxidase (MAO) enzymes oversee the concentration of neurotransmitters and intracellular amines in the brain and peripheral tissues by catalysing their oxidative deamination and represents a crucial target in drug designing for the…

Impact of Calcium Influx on Endoplasmic Reticulum in Excitotoxic Neurons: Role of Chemical Chaperone 4-PBA Open

Ankita Bhardwaj, Rishi Bhardwaj, Avneet Saini, D. K. Dhawan, Tanzeer Kaur · 2022

Development of Lateral Flow Assay for the Detection of Tamm Horsfall Protein in Urine Open

Tanvi Sharma, Rakesh Kumar Bijarnia, Tanzeer Kaur · 2022

Tamm Horsfall Protein (THP) is the most abundant urinary protein with concentrations of 20-200 mg/day and is known to be involved in a myriad of renal pathological processes such as renal stones and inflammation. THP is produced by renal e…

In vitro Studies on Calcium Oxalate Induced Apoptosis Attenuated by Didymocarpus pedicellata Open

Anubha Singh, Simran Tandon, Tanzeer Kaur, Chanderdeep Tandon · 2021

The present study focuses on exploring the antilithiatic potential of Didymocarpus pedicellata, which is valuable in managing renal disorders. Urolithiasis is an idiopathic disorder with a high recurrence and an incidence rate and is of ma…

Methylphenidate and Alprazolam Co-Abuse: Drug-DNA Interactions Open

Shweta Sharma, Meenu Dutt, Neha Sharma, Ravinder Naik Dharavath, Tanzeer Kaur · 2020

Drug abuse is a major issue worldwide. Methylphenidate (MPH) and alprazolam (ALZ) are commonly prescribed drugs for the treatment of ADHD and anxiety disorders, respectively. The limited studies suggest that abusers primarily use benzodiaz…

Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2 Open

Navpreet Kaur, Rimaljot Singh, Zahid Dar, Rakesh Kumar Bijarnia, Neelima Dhingra , et al. · 2020

An Overview of Novel Coronavirus Disease 2019: A Global Havoc Open

Zahid Dar, Lucky Chauhan, Monika Chauhan, Navpreet Kaur, Tanzeer Kaur , et al. · 2020

: The world has been pushed to the edge of a precipice commonly been addressed to as Coronavirus S (SARS-CoV2), one of the world’s most widespread viral pandemic in recent times. Many studies are underway and investigating the new role of …

<sup></sup><strong>Repurposing of FDA Approved Drugs as COVID-19 Therapeutics: Safety Concerns and Contraindications of Drugs in Clinical Trials</strong> Open

Ravinder Naik Dharavath, Meenu Dutt, Sunil Kumar, Priya Badyal, Nitin Rawat , et al. · 2020

Coronavirus disease (COVID-19) is the current global public health threat with no specific, effective, and approved treatment available till date. The outbreak of COVID-19 has led the world into an unimagined and uncertain situation by dis…

Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate Open

Shweta Sharma, Meenu Dutt, RavinderNaik Dharavath, Tanzeer Kaur, Navpreet Kaur , et al. · 2020

The co-abuse of ALZ has amplified the hepato-renal toxic effects of MPH. Therefore, it is a significant concern for public safety, and their co-abuse must be restricted and discouraged.

Delving into the Antiurolithiatic Potential of Tribulus terrestris Extract Through –In Vivo Efficacy and Preclinical Safety Investigations in Wistar Rats Open

Jyoti Kaushik, Simran Tandon, Rishi Bhardwaj, Tanzeer Kaur, Surinder Kumar Singla , et al. · 2019

Modern treatment interventions for kidney stones are wrought with side-effects, hence the need for alternative therapies such as plant-based medicines. We have previously documented through in vitro studies that statistically optimized aqu…

SP047IMPACT OF HYPEROXALURIA ON TAMM HORSFALL PROTEIN EXPRESSION AND STRUCTURAL ABERRATIONS IN RATS Open

Rishi Bhardwaj, Ankita Bhardwaj, Chanderdeep Tandon, D. K. Dhawan, Tanzeer Kaur · 2018

FP288INFLUENCE OF HYPEROXALURIA ON ENDOPLASMIC RETICULUM ENVIRONMENT AND ITS SUBSEQUENT IMPACT ON RENAL CELLS Open

Tanzeer Kaur, Rishi Bhardwaj · 2018

Formula; 23 Â (21.98 Â ([spot Na (mmol/l)/spot creatinine (mg/dl) Â 10] Â [-2.04 Â age (years)] þ [14.89Â weight (kg)] þ [16.14 height (cm)] -2244.45)0.392.RESULTS: Twenty-four hour urinary sodium was found associated with Kawasaki, Inters…

Perianal Crohn's disease: challenges and solutions Open

Khasanova Ka, Tanzeer Kaur, Tsikitis VL · 2017

Katherine A Kelley, Taranjeet Kaur, Vassiliki L Tsikitis Department of General Surgery, Division of Gastrointestinal and General Surgery, Oregon Health and Sciences University, Portland, OR, USA Abstract: Perianal Crohn’s disease affects a…

SALUBRIOUS EFFECT OF ROTTLERIN ON HYPEROXALURIA INDUCED OXIDATIVE DAMAGE IN RATS Open

Nirlep Chhiber, Tanzeer Kaur, Surinder Kumar Singla · 2016

Objective : To investigate the in vitro oxidant scavenging properties of rottlerin and to study the potential role of rottlerin on ethylene glycol induced nephrocalcinosis in rats. Methods : In vitro oxidant scavenging properties…

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