Xuetao Cao
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View article: Nomogram models for prediction of axillary lymph node metastasis in breast cancer patients
Nomogram models for prediction of axillary lymph node metastasis in breast cancer patients Open
We developed two preoperative nomograms that can be used to predict ALN metastasis (LN - vs. LN+) and the number of metastatic ALNs (≤ 2 vs. >2) in early breast cancer patients. They were well verified in internal testing groups. The nomog…
View article: Effectiveness of Anti-CD20 B cells depleting therapy versus conventional treatment in severe Anti-N-methyl-d-aspartate receptor encephalitis: A real-world multi-center prospective cohort study
Effectiveness of Anti-CD20 B cells depleting therapy versus conventional treatment in severe Anti-N-methyl-d-aspartate receptor encephalitis: A real-world multi-center prospective cohort study Open
Approximately 25 %-40 % of anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) patients develop refractory disease with prolonged neurological deficits. We aim to evaluate the efficacy of B cell depletion therapy (BCDT) via CD20 ant…
View article: Design, Deposition, Performance Evaluation, and Modulation Analysis of Nanocoatings for Cutting Tools: A Review
Design, Deposition, Performance Evaluation, and Modulation Analysis of Nanocoatings for Cutting Tools: A Review Open
With the rapid development of advanced machining technologies such as high-speed cutting, dry cutting, and ultra-precision cutting, as well as the widespread application of various difficult-to-machine materials, the surface degradation pr…
View article: The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation
The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation Open
RNA-binding proteins (RBP) are important for the initiation and resolution of inflammation, so better understanding of RBP-RNA interactions and their crosstalk with metabolism may provide alternate targets to controlling inflammation. Here…
View article: Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance Open
Aberrant expression and subcellular location of innate sensors in cancer cells, such as Toll-like receptors (TLRs), correlates with pro-tumoral inflammation and cancer progression, but the mechanism is still largely unknown. Deciphering th…
View article: In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation
In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation Open
Timely resolution of inflammation is essential to prevent tissue damage and maintain homeostasis. Immunometabolism is critical for innate immunity and inflammation. However, how metabolic enzymes and metabolites contribute to inflammatory …
View article: p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair
p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair Open
The multidomain protein cargo adaptor p62, also known as sequestosome 1, serves as a shuttling factor and adaptor for the degradation of substrates via the proteasome and autophagy pathways. Regarding its structure, p62 is composed of seve…
View article: SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins
SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins Open
Complement hyperactivation and thrombotic microangiopathy are closely associated with severe COVID-19. Endothelial dysfunction is a key mechanism underlying thrombotic microangiopathy. To address the relationship between endothelial injury…
View article: P1276 Persistent Insomnia Ignites the Flames of Crohn's Disease by Elevating Systemic Inflammation
P1276 Persistent Insomnia Ignites the Flames of Crohn's Disease by Elevating Systemic Inflammation Open
Background The association between insomnia and the risk of inflammatory bowel disease (IBD) remains inconclusive. We aim to investigate the association between insomnia and the risk of IBD, Crohn's disease (CD) and ulcerative colitis (UC)…
View article: Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1
Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1 Open
Uncontrolled TLR signaling can cause inflammatory immunopathology and trigger autoimmune diseases. For example, TLR7 promotes pathogenesis of systemic lupus erythematosus. However, whether RNA structural changes affect nucleic acids-sensin…
View article: Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation
Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation Open
2′-O-methylation is one of the most prevalent RNA modifications found in different RNA types. However, the identities of enzymes participating in the transfer of methyl groups are not well defined. To date, fibrillarin (FBL) is the only kn…
View article: Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution Open
How the lung achieves immune homeostasis after a pulmonary infection is not fully understood. Here, we analyzed the spatiotemporal changes in the lungs over a 2-week natural recovery from severe pneumonia in a Syrian hamster model of SARS-…
View article: Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection
Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection Open
How immune cells are spatiotemporally coordinated in the lung to effectively monitor, respond to, and resolve infection and inflammation in primed form needs to be fully illustrated. Here we apply immunocartography, a high-resolution techn…
View article: NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression
NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression Open
Tumor-intrinsic NPM1 promotes tumor immune evasion via suppressing IRF1-mediated antigen presentation to impair tumor immunogenicity and reprogram the immunosuppressive TME. Our study identifies NPM1 as a potential target for improving can…
View article: The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response Open
Ubiquitination is essential for the proteasomal turnover of IRF3, the central factor mediating the antiviral innate immune response. However, the spatiotemporal regulation of IRF3 ubiquitination for the precise activation and timely resolu…
View article: E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP‐1 Proteasomal Degradation
E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP‐1 Proteasomal Degradation Open
As a highly organized system, endo‐lysosomes play a crucial role in maintaining immune homeostasis. However, the mechanisms involved in regulating endo‐lysosome progression and subsequent inflammatory responses are not fully understood. By…
View article: Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway
Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway Open
Hydrogen therapy promotes macrophage polarization from M1 to M2 subtypes by inhibiting the NF-κB signalling pathway, thereby attenuating the inflammatory response to radiation lung injury.
View article: Dietary long‐chain fatty acid metabolism boosts antitumor immune response
Dietary long‐chain fatty acid metabolism boosts antitumor immune response Open
Overcoming resistance to immune checkpoint blockade (ICB) therapy will pave the way for effective ICB cancer immunotherapy since a large proportion of cancer patients are not responsive to ICB immunotherapy [1]. The molecular mechanisms of…