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View article: Plastic surgery at the crossroads: historical roots and emerging frontiers
Plastic surgery at the crossroads: historical roots and emerging frontiers Open
Plastic surgery, a venerable branch of surgical discipline, is imbued with a humanistic essence born from its origins in wartime reconstruction. It stands at the intersection of art and science, uniquely positioned by its association with …
View article: Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction
Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction Open
View article: ALKBH3‐Mediated M<sup>1</sup>A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M<sup>1</sup>A and M<sup>6</sup>A RNA Methylation (Adv. Sci. 19/2025)
ALKBH3‐Mediated M<sup>1</sup>A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M<sup>1</sup>A and M<sup>6</sup>A RNA Methylation (Adv. Sci. 19/2025) Open
Pathological Skin Fibrosis The artwork symbolises RNA modification crosstalk in skin fibrosis through Medusa and Perseus. Medusa's gaze symbolizing m(6)A methylation promotes fibrotic progression and transforms healthy skin into a rigid st…
View article: Ultrasound‐Driven Electric Conversion Hydrogel Coating Enhances Macrophage Efferocytosis for Non‐Invasive Skin Expansion
Ultrasound‐Driven Electric Conversion Hydrogel Coating Enhances Macrophage Efferocytosis for Non‐Invasive Skin Expansion Open
Skin soft‐tissue expansion, a key technique for tissue regeneration, promotes tissue repair by applying sustained mechanical tension. However, prolonged tension leads to the accumulation of apoptotic cells and impaired macrophage efferocyt…
View article: Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now?
Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now? Open
Keloids are a typical skin fibroproliferative disease that can cause severe aesthetic and functional concerns. Pain and pruritus are the most common clinical symptoms of keloids, but the mechanisms underlying these symptoms remain unclear.…
View article: Self‐Oxygenating PROTAC Microneedle for Spatiotemporally‐Confined Protein Degradation and Enhanced Glioblastoma Therapy
Self‐Oxygenating PROTAC Microneedle for Spatiotemporally‐Confined Protein Degradation and Enhanced Glioblastoma Therapy Open
Glioblastoma (GBM) is the most aggressive subtype of primary brain tumors, which marginally respond to standard chemotherapy due to the blood‐brain barrier (BBB) and the low tumor specificity of the therapeutics. Herein, a double‐layered m…
View article: ALKBH3‐Mediated M<sup>1</sup>A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M<sup>1</sup>A and M<sup>6</sup>A RNA Methylation
ALKBH3‐Mediated M<sup>1</sup>A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M<sup>1</sup>A and M<sup>6</sup>A RNA Methylation Open
Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m 1 A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect in pathological skin fibros…
View article: Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling
Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling Open
Background Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns. Pruritus and pain are the most prevalent clinical manifestations of keloids. Schwann cells (SCs) variation and neu…
View article: Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages
Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages Open
Hyperglycemia and bacterial colonization in diabetic wounds aberrantly activate Nod-like receptor protein 3 (NLRP3) in macrophages, resulting in extensive inflammatory infiltration and impaired wound healing. Targeted suppression of the NL…
View article: Application and exploration of interprofessional education in the teaching of plastic and reconstructive surgery: a narrative review
Application and exploration of interprofessional education in the teaching of plastic and reconstructive surgery: a narrative review Open
The growing discussion on "interdisciplinary integration" brings attention to the "interprofessional education" (IPE) in the field of plastic surgery. IPE not only improves the precision and effectiveness of plastic and reconstructive surg…
View article: ALKBH5‐mediated m<sup>6</sup>A demethylation ameliorates extracellular matrix deposition in cutaneous pathological fibrosis
ALKBH5‐mediated m<sup>6</sup>A demethylation ameliorates extracellular matrix deposition in cutaneous pathological fibrosis Open
Background Elevated extracellular matrix (ECM) accumulation is a major contributing factor to the pathogenesis of fibrotic diseases. Recent studies have indicated that N6‐methyladenosine (m 6 A) RNA modification plays a pivotal role in mod…
View article: Autologous Tissue Repair and Total Face Restoration
Autologous Tissue Repair and Total Face Restoration Open
Importance Total face restoration remains a challenge in modern reconstructive surgery. After 17 years of experiments and preliminary clinical studies, a new concept of face prefabrication was developed for face restoration with autologous…
View article: 33. Face Prefabrication For Total Face Restoration: An Innovative Approach & A Long-term Retrospective Study
33. Face Prefabrication For Total Face Restoration: An Innovative Approach & A Long-term Retrospective Study Open
PURPOSE: Total face restoration remains a challenge in modern reconstructive surgery. Face allotransplantation offers hope for patients, but several potential problems remain. After seventeen years of experiments and preliminary clinical s…
View article: “ludwigia sedioides” inspired substance-exchangeable spacer facilitating revascularization for skin repair
“ludwigia sedioides” inspired substance-exchangeable spacer facilitating revascularization for skin repair Open
Adequate substance exchange is an important prerequisite for tissue repair, and how to efficiently establish mature vascular networks to enhance the graft-host substance exchange is a challenge. Herein, inspired by the special structure of…
View article: Targeting the nuclear long noncoding transcript LSP1P5 abrogates extracellular matrix deposition by trans-upregulating CEBPA in keloids
Targeting the nuclear long noncoding transcript LSP1P5 abrogates extracellular matrix deposition by trans-upregulating CEBPA in keloids Open
View article: A treatment recommendation for trichoepithelioma: Thoughts on selection of treatment timing and method
A treatment recommendation for trichoepithelioma: Thoughts on selection of treatment timing and method Open
In this report, we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoepithelioma (MFT), with facial surface tumors that progressively worsened, causing ventilation disorders. In order to improve the …
View article: Immunomodulation of wound healing leading to efferocytosis
Immunomodulation of wound healing leading to efferocytosis Open
Effectively eliminating apoptotic cells is precisely controlled by a variety of signaling molecules and a phagocytic effect known as efferocytosis. Abnormalities in efferocytosis may bring about the development of chronic conditions, inclu…
View article: Salvaging Complex Lower Extremity Injury with Laparoscopically Harvested Omental Flaps
Salvaging Complex Lower Extremity Injury with Laparoscopically Harvested Omental Flaps Open
Laparoscopically harvested omental flap transplantation with skin grafting is an alternative reconstruction technique for severe lower extremity injuries with massive soft tissue loss and exposed bones and tendons.
View article: Corrigendum: Editorial: Recent innovations to inhibit scar formation for better skin regeneration
Corrigendum: Editorial: Recent innovations to inhibit scar formation for better skin regeneration Open
[This corrects the article DOI: 10.3389/fsurg.2023.1325832.].
View article: Identification of the optimal predictive cutoff value for expanded flap viability using indocyanine green angiography: a prospective study
Identification of the optimal predictive cutoff value for expanded flap viability using indocyanine green angiography: a prospective study Open
View article: Pre-expanded muscle-sparing latissimus dorsi flap in defect reconstruction and its application strategy
Pre-expanded muscle-sparing latissimus dorsi flap in defect reconstruction and its application strategy Open
View article: Editorial: Recent innovations to inhibit scar formation for better skin regeneration
Editorial: Recent innovations to inhibit scar formation for better skin regeneration Open
EDITORIAL article Front. Surg., 02 November 2023Sec. Reconstructive and Plastic Surgery Volume 10 - 2023 | https://doi.org/10.3389/fsurg.2023.1325832
View article: [Research advances in the treatment of keloid with glucocorticoids].
[Research advances in the treatment of keloid with glucocorticoids]. Open
As a first-line classical drug, glucocorticoids are used in most combination treatment regimens of keloid. However, there are issues such as poor treatment efficacy and recurrence of keloid after keloid was treated with glucocorticoids, wh…
View article: ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability
ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability Open
View article: Intraoperative Indocyanine Green Angiography Facilitates Flap Fenestration and Facial Organ Fabrication in Total Facial Restoration
Intraoperative Indocyanine Green Angiography Facilitates Flap Fenestration and Facial Organ Fabrication in Total Facial Restoration Open
Background: Because of a lack of effective measures to visualize flap vasculature and perfusion, flap fenestration and facial organ fabrication cannot be performed effectively, preventing the transition from two-dimensional coverage to res…
View article: Extracellular RNA in melanoma: Advances, challenges, and opportunities
Extracellular RNA in melanoma: Advances, challenges, and opportunities Open
Melanoma, a malignant mass lesion that originates in melanocytes and has a high rate of malignancy, metastasis, and mortality, is defined by these characteristics. Malignant melanoma is a kind of highly malignant tumor that produces melani…
View article: Lean adipose tissue macrophage derived exosome confers immunoregulation to improve wound healing in diabetes
Lean adipose tissue macrophage derived exosome confers immunoregulation to improve wound healing in diabetes Open
View article: Smart and versatile biomaterials for cutaneous wound healing
Smart and versatile biomaterials for cutaneous wound healing Open
The global increase of cutaneous wounds imposes huge health and financial burdens on patients and society. Despite improved wound healing outcomes, conventional wound dressings are far from ideal, owing to the complex healing process. Smar…
View article: Lean Adipose Tissue Macrophage Derived Exosome Confers Immunoregulation to Improve Wound Healing in Diabetes
Lean Adipose Tissue Macrophage Derived Exosome Confers Immunoregulation to Improve Wound Healing in Diabetes Open
Chronic non-healing wounds, an important complication of diabetes, are associated with increased mortality in patients afflicted with this disease. Excessive accumulation of M1 macrophages in diabetic wounds promotes inflammation and resul…
View article: Identification of MRAP protein family as broad‐spectrum GPCR modulators
Identification of MRAP protein family as broad‐spectrum GPCR modulators Open
Background The melanocortin receptor accessory proteins (MRAP1 and MRAP2) are well‐known endocrine regulators for the trafficking and signalling of all five melanocortin receptors (MC1R–MC5R). The observation of MRAP2 on regulating several…