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View article: HIF-2α-driven Lipogenesis and Inflammation in Metabolic Dysfunction-associated Steatotic Liver Disease: Role of ATF4 Signaling
HIF-2α-driven Lipogenesis and Inflammation in Metabolic Dysfunction-associated Steatotic Liver Disease: Role of ATF4 Signaling Open
These data indicate that HIF-2α acts as a contributing factor to MASLD progression via activating transcription factor 4 signaling.
View article: RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumour immunity
RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumour immunity Open
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor involved in innate immunity, but its role in adaptive immunity, specifically in the context of CD8 + T-cell antitumour immunity, remains unclear. Here, we demonstrate…
View article: Spheroid on-demand printing and drug screening of endothelialized hepatocellular carcinoma model at different stages
Spheroid on-demand printing and drug screening of endothelialized hepatocellular carcinoma model at different stages Open
Hepatocellular carcinoma (HCC) poses a significant threat to human health and medical care. Its dynamic microenvironment and stages of development will influence the treatment strategies in clinics. Reconstructing tumor–microvascular inter…
View article: Association of urinary phthalate metabolites with all-cause and cardiovascular disease mortality among adults with diabetes mellitus: National Health and Nutrition Examination Survey 2005–2014
Association of urinary phthalate metabolites with all-cause and cardiovascular disease mortality among adults with diabetes mellitus: National Health and Nutrition Examination Survey 2005–2014 Open
Background The study regarding phthalate metabolites and mortality among diabetes mellitus (DM) is limited. We aimed to examine the association of urinary phthalate metabolites with all-cause and cardiovascular disease (CVD) mortality amon…
View article: RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumor immunity
RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumor immunity Open
Background Although a variety of immune checkpoint monoclonal antibodies have been approved for the treatment of cancers, the low response rate of immune checkpoint inhibitors limits their wide clinical application. Therefore, to explore n…
View article: Association of fat-soluble vitamins (A, D, and E) status with humoral immune response to COVID-19 inactivated vaccination
Association of fat-soluble vitamins (A, D, and E) status with humoral immune response to COVID-19 inactivated vaccination Open
Background Fat-soluble vitamins (A, D, and E) are essential for the proper functioning of the immune system and are of central importance for infection risk in humans. Vitamins A, D, and E have been reported to be associated with the immun…
View article: Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease
Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease Open
Importance Cross-sectional evidence implicates high prevalent frailty in patients with Parkinson disease (PD), whereas the longitudinal association remains unknown. Objectives To examine the longitudinal association of the frailty phenotyp…
View article: Plasma Transthyretin Levels and Risk of Type 2 Diabetes Mellitus and Impaired Glucose Regulation in a Chinese Population
Plasma Transthyretin Levels and Risk of Type 2 Diabetes Mellitus and Impaired Glucose Regulation in a Chinese Population Open
Plasma transthyretin may be engaged in glucose regulation. We aimed to investigate the association between plasma transthyretin levels and the risk of newly diagnosed T2DM and impaired glucose regulation (IGR) in a Chinese population. We c…
View article: Associations of Plasma Fatty Acid Patterns During Pregnancy With Gestational Diabetes Mellitus
Associations of Plasma Fatty Acid Patterns During Pregnancy With Gestational Diabetes Mellitus Open
Background Limited studies have explored the difference of fatty acid profile between women with and without gestational diabetes mellitus (GDM), and the results were inconsistent. Individual fatty acids tend to be interrelated because of …
View article: Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis
Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis Open
Elevated plasma uric acid was associated with higher risk of insulin resistance, along with observation of gender difference in such association. However, our study does not support a causal role of plasma uric acid on insulin resistance a…
View article: Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke
Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke Open
This study suggested a positive association between plasma TMAO and ischemic stroke. Further studies are required to explore the role of plasma TMAO concentrations in predicting stroke risk.
View article: Plasma Alkylresorcinol Metabolite, A Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Metabolic Syndrome: A Case-Control Study
Plasma Alkylresorcinol Metabolite, A Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Metabolic Syndrome: A Case-Control Study Open
Background: Whole-grain intake assessed through dietary recording methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in several epidemiological studies. However, limited studies have evaluated the…
View article: Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components
Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components Open
The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine …
View article: Procyanidins Extracted from Lotus Seedpod Ameliorate Amyloid‐<i>β</i>‐Induced Toxicity in Rat Pheochromocytoma Cells
Procyanidins Extracted from Lotus Seedpod Ameliorate Amyloid‐<i>β</i>‐Induced Toxicity in Rat Pheochromocytoma Cells Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by extracellular senile plaque deposits, intracellular neurofibrillary tangles, and neuronal apoptosis. Amyloid‐ β (A β ) plays a critical role in …
View article: Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population
Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population Open
OBJECTIVE To examine the association of plasma alkylresorcinol metabolite 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, with type 2 diabetes (T2D) and impaired glucose regulation (IGR) i…
View article: Association of Plasma Magnesium with Prediabetes and Type 2 Diabetes Mellitus in Adults
Association of Plasma Magnesium with Prediabetes and Type 2 Diabetes Mellitus in Adults Open
Our study aimed to assess the associations of plasma magnesium with prediabetes and type 2 diabetes (T2D) among Chinese adults. We conducted a case-control analysis of 4447 participants: 867 newly diagnosed prediabetes patients, 1475 newly…
View article: Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study
Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study Open
Chromium has long been known as an enhancer of insulin action. However, the role of chromium in the development of type 2 diabetes mellitus (T2DM) in humans remains controversial. The current study aimed to examine the associations of plas…
View article: U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes
U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes Open
Our results suggested a U-shaped association between plasma manganese and T2D; both low and high levels of plasma manganese were associated with higher odds of newly diagnosed T2D. The U-shaped association was not modified by the MnSOD rs4…