Tara A. Gleeson
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View article: The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome Open
Hyperinflammatory disease is associated with an aberrant immune response resulting in cytokine storm. One such instance of hyperinflammatory disease is known as macrophage activation syndrome (MAS). The pathology of MAS can be characterise…
View article: The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome Open
Hyperinflammatory disease is associated with an aberrant immune response resulting in cytokine storm. One such instance of hyperinflammatory disease is known as macrophage activation syndrome (MAS). The pathology of MAS can be characterise…
View article: Looking into the IL-1 of the storm: are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes?
Looking into the IL-1 of the storm: are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes? Open
Summary Inflammasomes and the interleukin (IL)-1 family of cytokines are key mediators of both inflammation and immunothrombosis. Inflammasomes are responsible for the release of the pro-inflammatory cytokines IL-1β and IL-18, as well as r…