Tara Hicks
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View article: Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis
Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis Open
Faithful chromosome segregation into gametes depends on Spo11-induced DNA double-strand breaks (DSBs). These yield single-stranded 3' tails upon resection to promote crossovers (COs). While early Mre11-dependent end resection is the predom…
View article: R-loop-induced irreparable DNA damage evades checkpoint detection in the <i>C. elegans</i> germline
R-loop-induced irreparable DNA damage evades checkpoint detection in the <i>C. elegans</i> germline Open
Accumulation of DNA–RNA hybrids in the form of R-loops can result in replication–transcription conflict that leads to the formation of DNA double strand breaks (DSBs). Using null mutants for the two Caenorhabditis elegans genes encoding fo…