Tara Ness
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View article: Clinical standards for antimicrobial stewardship in TB care
Clinical standards for antimicrobial stewardship in TB care Open
BACKGROUNDWhile antimicrobial stewardship (AMS) is essential for combating antimicrobial resistance (AMR), TB-specific AMS strategies remain poorly defined.METHODSAn international panel of 62 experts participated in a Delphi process. Using…
View article: Screening and targeted sequencing of stool for microbiologic confirmation and drug resistance determination in paucibacillary tuberculosis
Screening and targeted sequencing of stool for microbiologic confirmation and drug resistance determination in paucibacillary tuberculosis Open
In 2023, an estimated 10.8 million people developed tuberculosis, and 1.25 million people died from this disease, including 161,000 deaths in people with HIV (PWH) in whom tuberculosis remains the leading cause of death. Detecting Mycobact…
View article: Application of FreezeTB, a targeted nanopore sequencing assay, for identification of drug resistance and lineages among pulmonary tuberculosis cases in Alaska
Application of FreezeTB, a targeted nanopore sequencing assay, for identification of drug resistance and lineages among pulmonary tuberculosis cases in Alaska Open
Alaska has the highest incidence of tuberculosis (TB) in the United States, with 8% mortality while undergoing TB treatment. With a quarter of TB cases lacking sputum culture to enable drug resistance testing, FreezeTB aimed to develop too…
View article: Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children
Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children Open
The protocol for this review was originally published through Cochrane in 2019. The protocol for this update was a generic protocol that consolidated previously published Cochrane protocols of Xpert Ultra for tuberculosis detection and can…
View article: Stool-Based Molecular Tuberculosis Treatment Monitoring: A Faster Means for Detecting Persistent Mycobacteria Compared to Phenotypic Culture
Stool-Based Molecular Tuberculosis Treatment Monitoring: A Faster Means for Detecting Persistent Mycobacteria Compared to Phenotypic Culture Open
Background Tuberculosis (TB) treatment monitoring is hindered by the lack of a rapidly measured biomarker that accurately predicts clinically relevant outcomes. Symptom screening poorly correlates with bacillary burden. Although culture is…
View article: Healthcare providers’ knowledge, attitudes, and perceptions from using targeted sequencing to diagnose and manage drug-resistant tuberculosis (DR-TB) in Eswatini
Healthcare providers’ knowledge, attitudes, and perceptions from using targeted sequencing to diagnose and manage drug-resistant tuberculosis (DR-TB) in Eswatini Open
Challenges in diagnosing drug-resistant tuberculosis (DR-TB) contribute to a diagnostic gap. Design-locked Targeted Sequencing (TS) assays have the potential to improve DR-TB diagnosis and management. TS assays are now being introduced int…
View article: Rapid Diagnostic Sequencing of Stool DNA Using Targeted Nanopore Sequencing in Patients With a Pulmonary Tuberculosis Diagnosis
Rapid Diagnostic Sequencing of Stool DNA Using Targeted Nanopore Sequencing in Patients With a Pulmonary Tuberculosis Diagnosis Open
Background Approximately 1.25 million individuals died of tuberculosis in 2023, in part due to ineffective treatment. In patients with paucibacillary tuberculosis, microbiologic confirmation and drug resistance testing via respiratory spec…
View article: Performance of a stool-based quantitative PCR assay for the diagnosis of tuberculosis in adolescents and adults: a multinational, prospective diagnostic accuracy study
Performance of a stool-based quantitative PCR assay for the diagnosis of tuberculosis in adolescents and adults: a multinational, prospective diagnostic accuracy study Open
National Institutes of Health (NIH) Allergy and Infectious Diseases, and NIH Fogarty International Center.
View article: Tuberculosis prevention: current strategies and future directions
Tuberculosis prevention: current strategies and future directions Open
Effective tuberculosis prevention worldwide requires a multipronged approach that addresses social determinants, and improves access to tuberculosis detection and to new short tuberculosis preventive treatment regimens. Robust collaboratio…
View article: A Model of Fellowship Stewardship Education: Response to Wasson et al
A Model of Fellowship Stewardship Education: Response to Wasson et al Open
Journal Article Corrected proof A Model of Fellowship Stewardship Education: Response to Wasson et al Get access Tara E Ness, Tara E Ness Division of Pediatric Infectious Diseases, Texas Children's Hospital, Houston, Texas, USA Corresponde…
View article: Rolling out new anti-tuberculosis drugs without diagnostic capacity
Rolling out new anti-tuberculosis drugs without diagnostic capacity Open
Deaths from tuberculosis (TB) reached over 1.6 million in 2021 with 10.6 million people becoming ill. Multidrug-resistant TB, defined as the Mycobacterium tuberculosis organism having resistance to at least isoniazid and rifampicin, repres…
View article: Optimizing DNA Extraction from Pediatric Stool for Diagnosis of Tuberculosis and Use in Next-Generation Sequencing Applications
Optimizing DNA Extraction from Pediatric Stool for Diagnosis of Tuberculosis and Use in Next-Generation Sequencing Applications Open
This is the first study to compare Mycobacterium tuberculosis DNA extraction techniques from pediatric stool samples for use with sequencing technologies. It provides an important starting point for other researchers to isolate quality DNA…
View article: 326. Optimizing DNA Extraction from Pediatric Stool for Diagnosing Tuberculosis and Use in Next Generation Sequencing
326. Optimizing DNA Extraction from Pediatric Stool for Diagnosing Tuberculosis and Use in Next Generation Sequencing Open
Background Next generation sequencing (NGS) is quickly coming to the forefront of diagnostic tools to provide efficient, highly informative information from patient samples. Recently, it was established that patients with pulmonary Tubercu…
View article: High Throughput Sequencing for Clinical Tuberculosis: An Overview
High Throughput Sequencing for Clinical Tuberculosis: An Overview Open
High throughput sequencing (HTS) can identify the presence of Mycobacterium tuberculosis DNA in a clinical sample while also providing information on drug susceptibility. Multiple studies have provided a context for exploring the clinical …
View article: Pediatric Eosinophilia: A Review and Multiyear Investigation into Etiologies
Pediatric Eosinophilia: A Review and Multiyear Investigation into Etiologies Open
More information on the etiology of pediatric eosinophilia and workup data could help identify the causes. This study provides important information on the evaluation of eosinophilia in the US pediatric population, including a diagnostic a…
View article: Optimal Timing of Antiretroviral Therapy Initiation in Children and Adolescents With Human Immunodeficiency Virus-Associated Pulmonary Tuberculosis
Optimal Timing of Antiretroviral Therapy Initiation in Children and Adolescents With Human Immunodeficiency Virus-Associated Pulmonary Tuberculosis Open
Background There is insufficient evidence in children and adolescents with human immunodeficiency virus (CAHIV) to guide the timing of antiretroviral treatment (ART) initiation after starting treatment for pulmonary tuberculosis (pTB). To …
View article: Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children
Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children Open
We found Xpert Ultra sensitivity to vary by specimen type, with sputum having the highest sensitivity, followed by gastric aspirate and stool. Nasopharyngeal aspirate had the lowest sensitivity. Xpert Ultra specificity was high against bot…
View article: How I Approach Leishmaniasis: Diagnosis and Treatment in the United States
How I Approach Leishmaniasis: Diagnosis and Treatment in the United States Open
Leishmaniasis is a vector-borne disease caused by over 20 species of obligate intracellular protozoa belonging to the genus Leishmania. Leishmaniasis has a global distribution, including in the United States, and can cause a spectrum of cl…
View article: Impact of using creative arts programming to support HIV treatment in adolescents and young adults in Eswatini
Impact of using creative arts programming to support HIV treatment in adolescents and young adults in Eswatini Open
Background In 2018, approximately 1.6 million adolescents (aged 10–19) were living with HIV worldwide, with the highest HIV prevalence found in Eswatini. Adolescents and young adults living with HIV are a vulnerable population due to uniqu…
View article: 722. Parasitic and Non-Parasitic Causes of Eosinophilia in Children Presenting to a Tertiary Care Center in the United States
722. Parasitic and Non-Parasitic Causes of Eosinophilia in Children Presenting to a Tertiary Care Center in the United States Open
Background Peripheral eosinophilia can be caused by many underlying conditions, including infectious pathogens, allergic disorders, neoplastic disorders, and immunological disorders. However, uncovering the cause of eosinophilia in childre…
View article: 1169. Revenge of the Syph(ilis): Investigating Congenital Syphilis at a Tertiary Care Center Amidst a Rising Epidemic
1169. Revenge of the Syph(ilis): Investigating Congenital Syphilis at a Tertiary Care Center Amidst a Rising Epidemic Open
Background Congenital syphilis is a chronic infection acquired by the fetus in utero from a mother infected with Treponema palladium. It has a large spectrum of disease manifestations from asymptomatic infection to blindness, abnormal bone…
View article: Screening tests for active pulmonary tuberculosis in children
Screening tests for active pulmonary tuberculosis in children Open
We found that in children who are tuberculosis contacts or living with HIV, screening tests using symptoms or CXR may be useful, but our review is limited by design issues with the index test and incorporation bias in the reference standar…
View article: Evaluating antibiotic use and developing a tool to optimize prescribing in a family-centered HIV clinic in Eswatini
Evaluating antibiotic use and developing a tool to optimize prescribing in a family-centered HIV clinic in Eswatini Open
In a human immunodeficiency virus (HIV) clinic for children and their families in Eswatini, we sought to understand the use of antibiotics and identify specific areas for improvement. We performed a retrospective patient chart review as pa…
View article: Sexual Behavior and Sexually Transmitted Infection Outcomes Among Men Who Have Sex With Men and Transgender Women Participating in a Study of the Timing of Antiretroviral Therapy in Lima, Peru
Sexual Behavior and Sexually Transmitted Infection Outcomes Among Men Who Have Sex With Men and Transgender Women Participating in a Study of the Timing of Antiretroviral Therapy in Lima, Peru Open
Background We assessed sexual behavior and incidence of sexually transmitted infections (STIs) among men who have sex with men and transgender women participating in Sabes , a study of an expanded treatment as prevention strategy focused o…
View article: 156. Evaluating Antibiotic Use and Developing a Tool to Optimize Prescribing in a Pediatric HIV Clinic in Eswatini
156. Evaluating Antibiotic Use and Developing a Tool to Optimize Prescribing in a Pediatric HIV Clinic in Eswatini Open
Background Antibiotic resistance is an emerging global health issue, fueled by inadequate surveillance systems and the absence of antimicrobial stewardship. In resource-limited settings, antimicrobial use is often based on clinical evaluat…
View article: 940. Impact of Using Arts Programming to Support Treatment in Adolescents Living with HIV in Eswatini
940. Impact of Using Arts Programming to Support Treatment in Adolescents Living with HIV in Eswatini Open
Background Adolescents and young adults with HIV are a unique population given the distinct psychosocial challenges of their age-group coupled with having a stigmatizing disease. In 2018, approximately 1.6 million adolescents were living w…