Tara R. deBoer
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View article: Genetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Cohort: Insights into the Phenotypic and Genetic Basis of Coresistance
Genetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Cohort: Insights into the Phenotypic and Genetic Basis of Coresistance Open
The rising incidence of resistance to expanded-spectrum cephalosporins among Escherichia coli strains, the most common cause of UTIs, is threatening our ability to successfully empirically treat these infections. ESCR E. coli strains are o…
View article: A Dual Enzyme-Based Biochemical Test Rapidly Detects Third-Generation Cephalosporin-Resistant CTX-M-Producing Uropathogens in Clinical Urine Samples
A Dual Enzyme-Based Biochemical Test Rapidly Detects Third-Generation Cephalosporin-Resistant CTX-M-Producing Uropathogens in Clinical Urine Samples Open
Extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria (GNB) are increasingly identified as the cause of both community and healthcare-associated urinary tract infections (UTIs), with CTX-Ms being the most common ESBLs ident…
View article: Peroxynitrite-Mediated Dimerization of 3-Nitrotyrosine: Unique Chemistry along the Spectrum of Peroxynitrite-Mediated Nitration of Tyrosine
Peroxynitrite-Mediated Dimerization of 3-Nitrotyrosine: Unique Chemistry along the Spectrum of Peroxynitrite-Mediated Nitration of Tyrosine Open
Peroxynitrite (ONOO-, PN) has long been considered a potent nitrating agent implicated in numerous inflammation-mediated diseases. The current work highlights an unexplored oxidation chemistry initiated under conditions of susta…
View article: Cover Feature: An Enzyme‐Mediated Amplification Strategy Enables Detection of β‐Lactamase Activity Directly in Unprocessed Clinical Samples for Phenotypic Detection of β‐Lactam Resistance (ChemBioChem 20/2018)
Cover Feature: An Enzyme‐Mediated Amplification Strategy Enables Detection of β‐Lactamase Activity Directly in Unprocessed Clinical Samples for Phenotypic Detection of β‐Lactam Resistance (ChemBioChem 20/2018) Open
The cover feature picture shows a pictorial representation of the enzyme-empowered amplification technology, DETECT. This amplification strategy was applied to enhance the detection of the antibiotic resistance-conferring enzyme, β-lactama…
View article: An Enzyme‐Mediated Amplification Strategy Enables Detection of β‐Lactamase Activity Directly in Unprocessed Clinical Samples for Phenotypic Detection of β‐Lactam Resistance
An Enzyme‐Mediated Amplification Strategy Enables Detection of β‐Lactamase Activity Directly in Unprocessed Clinical Samples for Phenotypic Detection of β‐Lactam Resistance Open
Biochemical assays that can identify β‐lactamase activity directly from patient samples have the potential to significantly improve the treatment of bacterial infections. However, current β‐lactamase probes do not have the sensitivity need…
View article: A Cleavage-Responsive Stem-Loop Hairpin for Assaying Guide RNA Activity
A Cleavage-Responsive Stem-Loop Hairpin for Assaying Guide RNA Activity Open
The scope of the CRISPR-Cas9 technology now reaches far beyond genomic engineering. While significant efforts are driving the evolution of this revolutionary biomedical tool, the in vitro cleavage assay remains the standard method implemen…
View article: Design and construction of a silver(I)-loaded cellulose-based wound dressing: trackable and sustained release of silver for controlled therapeutic delivery to wound sites
Design and construction of a silver(I)-loaded cellulose-based wound dressing: trackable and sustained release of silver for controlled therapeutic delivery to wound sites Open
View article: The Design and Construction of a Biomimetic Peroxynitrite-Generating Platform: An Analytical Tool to Study the Dynamic Chemistry of Peroxynitrite
The Design and Construction of a Biomimetic Peroxynitrite-Generating Platform: An Analytical Tool to Study the Dynamic Chemistry of Peroxynitrite Open
Peroxynitrite is a reactive nitrogen species that has remained at the center of controversy since the time of its discovery in the early 1990âs. The reactive nature of PN required unique chemical synthetic approaches and techniques to be…
View article: CCDC 1007178: Experimental Crystal Structure Determination
CCDC 1007178: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1013954: Experimental Crystal Structure Determination
CCDC 1013954: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1007179: Experimental Crystal Structure Determination
CCDC 1007179: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1007177: Experimental Crystal Structure Determination
CCDC 1007177: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …