Taral R. Lunavat
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View article: Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity
Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity Open
The standard of care in high-grade gliomas has remained unchanged in the past 20 years. Efforts to replicate effective immunotherapies in non-cranial tumors have led to only modest therapeutical improvements for patients with glioma. Here,…
View article: Multimodal Imaging of Brain Metastasis-Derived Extracellular Vesicles Using Superparamagnetic Iron Oxide Nanoparticle Labeling
Multimodal Imaging of Brain Metastasis-Derived Extracellular Vesicles Using Superparamagnetic Iron Oxide Nanoparticle Labeling Open
This study establishes a reliable protocol for labeling BM-derived EVs with SPIONs, enabling their visualization across various biological contexts, from subcellular to tissue levels. This proposed model facilitates a valuable tool for spa…
View article: Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity
Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity Open
The standard of care in high-grade gliomas has remained unchanged in the past 20 years. Efforts to replicate effective immunotherapies in non-cranial tumors have led to only modest therapeutical improvements in glioblastoma (GB). Here, we …
View article: Roles of extracellular vesicles in glioblastoma: foes, friends and informers
Roles of extracellular vesicles in glioblastoma: foes, friends and informers Open
Glioblastoma (GB) tumors are one of the most insidious cancers which take over the brain and defy therapy. Over time and in response to treatment the tumor and the brain cells in the tumor microenvironment (TME) undergo many genetic/epigen…
View article: CNSC-15. MITOCHONDRIA TRANSFER VIA GLIOMA-ASTROCYTE NETWORK MICROTUBES REPROGRAMS TUMOR CELLS FOR ENHANCED TUMORIGENICITY
CNSC-15. MITOCHONDRIA TRANSFER VIA GLIOMA-ASTROCYTE NETWORK MICROTUBES REPROGRAMS TUMOR CELLS FOR ENHANCED TUMORIGENICITY Open
Glioblastoma (GBM) interaction with neural cells is critical to its pathobiology. Emerging evidence suggests that GBM cells form an interconnected network with astrocytes, facilitating tumor persistence. Given reports of intercellular tran…
View article: TMIC-47. INHIBITION OF MIR-146A-5P DECREASES PROGRESSION OF MELANOMA BRAIN METASTASIS VIA NOTCH PATHWAY DYSREGULATION IN ASTROCYTES
TMIC-47. INHIBITION OF MIR-146A-5P DECREASES PROGRESSION OF MELANOMA BRAIN METASTASIS VIA NOTCH PATHWAY DYSREGULATION IN ASTROCYTES Open
Melanoma has a high propensity for brain metastasis, occurring in 40% of late-stage patients. The progression of secondary tumors in the brain depends on the support of the surrounding microenvironment, emphasizing the importance of modula…
View article: Inhibition of extracellular vesicle‐derived miR‐146a‐5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes
Inhibition of extracellular vesicle‐derived miR‐146a‐5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes Open
Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late‐stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis establishment, cell s…
View article: GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity Open
View article: Supplementary Table S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Table S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Table S2. Gene list.
View article: Supplementary Table S1 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Table S1 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Table S1. Microarray analysis.
View article: Supplementary Figure S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S2. Role of miR-218 investigated in additional cancer entities.
View article: Supplementary Figure S1 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S1 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S1. mRNA expression profiles in resected metastases and matched primary tumors and normal tissues.
View article: Supplementary Figure Legend from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure Legend from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Legends for Supplementary Figures S1-S7.
View article: Data from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Data from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
The microRNA (miRNA) landscape changes during the progression of cancer. We defined a metastasis-associated miRNA landscape using a systematic approach. We profiled and validated miRNA and mRNA expression in a unique series of human colore…
View article: Supplementary Figure S1 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S1 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S1. mRNA expression profiles in resected metastases and matched primary tumors and normal tissues.
View article: Supplementary Figure Legend from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure Legend from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Legends for Supplementary Figures S1-S7.
View article: Supplementary Figure S7 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S7 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S7. TCGA colorectal cancer database analysis on selected targets.
View article: Supplementary Figure S6 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S6 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S6. Independent in vivo validation of the novel miRNA-network in brain tumors in the Oncomine database.
View article: Supplementary Table S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Table S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Table S2. Gene list.
View article: Supplementary Figure S7 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S7 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S7. TCGA colorectal cancer database analysis on selected targets.
View article: Supplementary Figure S3 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S3 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S3. EMT following miR-135b/210 transfection.
View article: Supplementary Figure S6 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S6 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S6. Independent in vivo validation of the novel miRNA-network in brain tumors in the Oncomine database.
View article: Supplementary Figure S5 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S5 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S5. FOXN3 significantly enhances survival in a small cohort of TCGA colorectal cancer samples.
View article: Supplementary Figure S3 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S3 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S3. EMT following miR-135b/210 transfection.
View article: Supplementary Figure S4 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S4 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S4. Cell line screening.
View article: Data from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Data from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
The microRNA (miRNA) landscape changes during the progression of cancer. We defined a metastasis-associated miRNA landscape using a systematic approach. We profiled and validated miRNA and mRNA expression in a unique series of human colore…
View article: Supplementary Methods from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Methods from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Methods. Description of additional methods and procedures used in the study.
View article: Supplementary Figure S4 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S4 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S4. Cell line screening.
View article: Supplementary Figure S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S2. Role of miR-218 investigated in additional cancer entities.
View article: Supplementary Figure S5 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Supplementary Figure S5 from A Systematic Approach to Defining the microRNA Landscape in Metastasis Open
Supplementary Figure S5. FOXN3 significantly enhances survival in a small cohort of TCGA colorectal cancer samples.