Taraneh Hajian
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View article: Inhibition of <i>Clostridioides difficile-</i>specific DNA adenine methyltransferase CamA by analogs of <i>S</i>-adenosyl-L-methionine
Inhibition of <i>Clostridioides difficile-</i>specific DNA adenine methyltransferase CamA by analogs of <i>S</i>-adenosyl-L-methionine Open
Epigenetically-targeted therapies, especially those inhibiting S -adenosyl-L-methionine (SAM)- dependent methylations of DNA, mRNA and histones, have advanced rapidly in cancer treatment. However, these therapies remain underexplored for a…
View article: OICR-41103 as a chemical probe for the DCAF1 WD40 domain
OICR-41103 as a chemical probe for the DCAF1 WD40 domain Open
Human DCAF1 is a multidomain protein that plays a critical role in protein homeostasis. Its WDR domain functions as a substrate recruitment module for RING-type CRL4 and HECT family EDVP E3 ubiquitin ligases, enabling the ubiquitination an…
View article: Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity Open
View article: Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity Open
Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets, particularly undruggable proteins, for more than two decades. They have been employed by various groups successfully, however only a handful o…
View article: Kinetic characterization of human mRNA guanine-N7 methyltransferase
Kinetic characterization of human mRNA guanine-N7 methyltransferase Open
View article: Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2 Open
Nuclear receptor-binding SET domain-containing 2 (NSD2) plays important roles in gene regulation, largely through its ability to dimethylate lysine 36 of histone 3 (H3K36me2). Despite aberrant activity of NSD2 reported in numerous cancers,…
View article: Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase Open
S-Adenosyl-l-methionine (SAM) analogs are adaptable tools for studying and therapeutically inhibiting SAM-dependent methyltransferases (MTases). Some MTases play significant roles in host-pathogen interactions, one of which is Cl…
View article: SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses
SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses Open
Seven coronaviruses have infected humans (HCoVs) to-date. SARS-CoV-2 caused the current COVID-19 pandemic with the well-known high mortality and severe socioeconomic consequences. MERS-CoV and SARS-CoV caused epidemic of MERS and SARS, res…
View article: Systematic Design of Adenosine Analogs as Inhibitors of a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence
Systematic Design of Adenosine Analogs as Inhibitors of a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence Open
Antivirulence agents targeting endospore-transmitted Clostridioides difficile infections are urgently needed. C. difficile-specific DNA adenine methyltransferase (CamA) is required for efficient sporulation and affects persis…
View article: Crystal structure of <scp>SARS‐CoV</scp>‐2 nsp10–nsp16 in complex with small molecule inhibitors, <scp>SS148</scp> and <scp>WZ16</scp>
Crystal structure of <span>SARS‐CoV</span>‐2 nsp10–nsp16 in complex with small molecule inhibitors, <span>SS148</span> and <span>WZ16</span> Open
SARS‐CoV‐2 nsp10–nsp16 complex is a 2′‐O‐methyltransferase (MTase) involved in viral RNA capping, enabling the virus to evade the immune system in humans. It has been considered a valuable target in the discovery of antiviral therapeutics,…
View article: Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors Open
View article: Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions Open
MettL3-MettL14 methyltransferase complex has been studied widely for its role in RNA adenine methylation. This complex is also recruited to UV- and X-ray exposed DNA damaged sites, and its methyltransfer activity is required for subsequent…
View article: A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex Open
View article: Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors Open
The COVID-19 pandemic has clearly brought the healthcare systems world-wide to a breaking point along with devastating socioeconomic consequences. The SARS-CoV-2 virus which causes the disease uses RNA capping to evade the human immune sys…
View article: A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex
A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex Open
Frequent outbreaks of novel coronaviruses (CoVs), highlighted by the current SARS-CoV-2 pandemic, necessitate the development of therapeutics that could be easily and effectively administered world-wide. The conserved mRNA-capping process …
View article: A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19 Open
View article: 20201020_NSD3_247-402_NHis_Purification Protocol
20201020_NSD3_247-402_NHis_Purification Protocol Open
NSD3_247-402_NHis_Expression and Purification Protocol
View article: 20201020_NSD3_247-402_NHis_Purification Protocol
20201020_NSD3_247-402_NHis_Purification Protocol Open
NSD3_247-402_NHis_Expression and Purification Protocol
View article: 20201020_NSD2_208-368_NHis _Purification Protocol
20201020_NSD2_208-368_NHis _Purification Protocol Open
NSD2_208-368_NHis _Expression and Purification Protocol
View article: 20201020_NSD2_208-368_NHis _Purification Protocol
20201020_NSD2_208-368_NHis _Purification Protocol Open
NSD2_208-368_NHis _Expression and Purification Protocol
View article: 20200520_FBXW7_349-707_NHis_Purification Protocol
20200520_FBXW7_349-707_NHis_Purification Protocol Open
FBXW7_349-707_NHis_Expression and Purification Protocol
View article: 20200520_FBXW7_349-707_NHis_Purification Protocol
20200520_FBXW7_349-707_NHis_Purification Protocol Open
FBXW7_349-707_NHis_Expression and Purification Protocol
View article: 20200329_TEAD4_212-434_NHis_Expression and Purification Protocol
20200329_TEAD4_212-434_NHis_Expression and Purification Protocol Open
TEAD4_212-434_NHis_Expression and Purification Protocol
View article: 20200329_TEAD4_212-434_NHis_Expression and Purification Protocol
20200329_TEAD4_212-434_NHis_Expression and Purification Protocol Open
TEAD4_212-434_NHis_Expression and Purification Protocol
View article: A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19
A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19 Open
SARS-CoV-2, the coronavirus that causes COVID-19, evades the human immune system by capping its RNA. This process protects the viral RNA and is essential for its replication. Multiple viral proteins are involved in this RNA capping process…
View article: Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion
Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion Open
View article: Bio NSD3 PWWP1 Expression and Purification Protocol
Bio NSD3 PWWP1 Expression and Purification Protocol Open
Bio NSD3 PWWP1 Expression and Purification Protocol
View article: Bio NSD3 PWWP1 Expression and Purification Protocol
Bio NSD3 PWWP1 Expression and Purification Protocol Open
Bio NSD3 PWWP1 Expression and Purification Protocol
View article: BIO NSD2 PWWP1 Expression and Purification Protocol
BIO NSD2 PWWP1 Expression and Purification Protocol Open
Biotinylated NSD2 PWWP1 Expression and Purification Protocol
View article: BIO NSD2 PWWP1 Expression and Purification Protocol
BIO NSD2 PWWP1 Expression and Purification Protocol Open
Biotinylated NSD2 PWWP1 Expression and Purification Protocol