Taraneh Sadritabrizi
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View article: Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations
Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations Open
Rationale Hyper IgE syndrome (STAT3-HIES), also known as Job’s syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. STAT3-HIES syndrome is characterized by chronic pulmonary infection and infl…
View article: BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance
BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance Open
BPIFB1, also known as LPLUNC1, was found to regulate mucociliary clearance (MCC), a key aspect of host defense in the airway. Loss of this protein was also associated with altered biophysical and biochemical properties of mucus that have b…
View article: 193 Role of IL-1β in innate host defense of normal airway epithelia
193 Role of IL-1β in innate host defense of normal airway epithelia Open