Taravat Bamdad
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View article: Oncolytic reovirus enhances the effect of CEA immunotherapy when combined with PD1-PDL1 inhibitor by reducing the immunosuppressive tumor microenvironment in a colorectal cancer model
Oncolytic reovirus enhances the effect of CEA immunotherapy when combined with PD1-PDL1 inhibitor by reducing the immunosuppressive tumor microenvironment in a colorectal cancer model Open
Immunotherapy is a type of tumor treatment that increases anti-tumor immunity to inhibit tumor growth. By enhancing the immune response through the lysis of tumor cells with an oncolytic virus and inhibiting the immune system's inhibitory …
View article: Comparison of three different methods of transfection for production of recombinant adenovirus vector expressing human carcinoembryonic antigen (CEA) gene
Comparison of three different methods of transfection for production of recombinant adenovirus vector expressing human carcinoembryonic antigen (CEA) gene Open
Adenoviral vectors (AdV) are widely used as gene delivery vehicle and vaccine design due to their genetic stability, large transfer gene capacity, production at high titers, remarkable efficacy of transduction, etc. Using of AdV in cancer …
View article: Persistence of SARS-CoV-2-antibodies against N, S and RBD after natural infection
Persistence of SARS-CoV-2-antibodies against N, S and RBD after natural infection Open
Background and Objectives: Coronavirus disease 2019 (COVID-19) pandemic has affected most countries in the world. Monitoring the humoral immune responses during the natural course of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Co…
View article: Comparison of Three Different Methods of Transfection for the Production of Recombinant Adenovirus Expressing Human Carcinoembryonic Antigen Gene.
Comparison of Three Different Methods of Transfection for the Production of Recombinant Adenovirus Expressing Human Carcinoembryonic Antigen Gene. Open
Adenoviral vectors (AdVs) are widely used as a gene delivery vehicle and vaccine design due to their genetic stability, transfer capacity of large genes, production at high titers, and remarkable efficacy of transduction. One of the most i…
View article: Expression and Purification of SARS CoV-2 RBD Protein in the Prokaryotic Expression System to Evaluate the IgG Antibody in the Serums of COVID-19 Recovered Cases
Expression and Purification of SARS CoV-2 RBD Protein in the Prokaryotic Expression System to Evaluate the IgG Antibody in the Serums of COVID-19 Recovered Cases Open
زمینه و هدف یکی از مهمترین پروتئینهای ویروس 2-COV–SARS پروتئین S است که از دو زیرواحد 1S و 2S تشکیل شدهاست. مهمترین ناحیه در زیرواحد S1 ناحیه اتصال به رسپتور ) RBD ( است که نقش کلیدی در اتصال به رسپتورهای ACE راایفا میکند. RBD یک ناحیه حفا…
View article: Prevalence of herpes simplex viruses types 1 and 2 infections among suspected children of encephalitis in Kermanshah, Iran
Prevalence of herpes simplex viruses types 1 and 2 infections among suspected children of encephalitis in Kermanshah, Iran Open
Background and Objectives: Various infectious and non-infectious factors can cause encephalitis in the central nervous system (CNS), the most important of which are viruses. Herpes viruses are one of the most important causes of encephalit…
View article: EBNA1 Upregulates P53-Inhibiting Genes in Burkitt's Lymphoma Cell Line
EBNA1 Upregulates P53-Inhibiting Genes in Burkitt's Lymphoma Cell Line Open
It seems that EBNA1 could strongly upregulate p53-inhibiting genes including HDAC1, MDM2, MDM4, and USP7. Moreover, it appears that the effects of USP7 suppression on p53 at protein/mRNA level depend on the cell nature; however, further re…
View article: In Silico Analysis of Neutralizing Antibody Epitopes on The Hepatitis C Virus Surface Glycoproteins.
In Silico Analysis of Neutralizing Antibody Epitopes on The Hepatitis C Virus Surface Glycoproteins. Open
Using an innovative filtration strategy, the residues of E2 epitopes which have the best in silico binding affinity to neutralizing antibodies were exhibited and a distinct peptide library platform was designed.
View article: Comparison of the inhibitory and stimulatory effects of Core and NS3 candidate HCV vaccines on the cellular immune response.
Comparison of the inhibitory and stimulatory effects of Core and NS3 candidate HCV vaccines on the cellular immune response. Open
Currently, hepatitis C virus (HCV) infects nearly 3% of the global population, the majority of whom are chronically infected; however, hepatitis C vaccines are still in the developmental stage. Numerous studies suggest that the spontaneous…
View article: A New Insight Into p53-Inhibiting Genes in Epstein–Barr Virus-Associated Gastric Adenocarcinoma
A New Insight Into p53-Inhibiting Genes in Epstein–Barr Virus-Associated Gastric Adenocarcinoma Open
EBNA1 enhances the expression of p53-inhibiting genes. Two events—p53 protein overexpression and apoptosis activation—followed the suppression of the USP7 protein and provided evidence for its possible function. The significance of the EBN…
View article: Anti-hepatitis C virus antibody status and outcomes in serologic assays in blood donors
Anti-hepatitis C virus antibody status and outcomes in serologic assays in blood donors Open
BACKGROUND: Hepatitis C virus (HCV) is a major issue in the field of blood transfusion safety and blood components. Serological tests are used to detect anti-HCV antibodies in blood donors. This study was performed to evaluate the status o…
View article: Genomic and serological assessment of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in child labor
Genomic and serological assessment of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in child labor Open
Since working children have limited access to testing and monitoring for COVID-19, we decided to measure SARS-CoV-2 prevalence among them and compare it to non-working children. Our objective is to compare the frequency of SARS-CoV-2 genom…
View article: Who Is Immune Against COVID-19 and Safe to Return to Work: The Impact of Laboratory Assays
Who Is Immune Against COVID-19 and Safe to Return to Work: The Impact of Laboratory Assays Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19) as a pandemic infectious disease which has led to thousands of deaths around the world. The Coronaviridae family is the second…
View article: Establishment a Carcinoembryonic Antigen Stable Cell Line for Cancer Immunotherapy Study
Establishment a Carcinoembryonic Antigen Stable Cell Line for Cancer Immunotherapy Study Open
Introduction:Cancer immunotherapy is one of the effective treatment methods that provide a better quality of life with limited side effects for patients.Carcinoembryonic Antigen (CEA) can be an appropriate target for cancer immunotherapy.M…
View article: False-Negative Results in Taqman One-Step RT-PCR Test: Evaluation of Endogenous Internal Control Function Used in SARS-CoV-2 Detection Tests
False-Negative Results in Taqman One-Step RT-PCR Test: Evaluation of Endogenous Internal Control Function Used in SARS-CoV-2 Detection Tests Open
Background: Taqman one-step real-time PCR (RT-PCR) has special importance due to its high sensitivity and specificity in the diagnosis of infectious diseases such as viral infections. In the recent pandemic of SARS-CoV-2, diagnostic kits b…
View article: SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports
SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports Open
Background SARS-CoV-2 has led to the current pandemic of respiratory disease. The reports of confirmed COVID-19 cases based on molecular tests do not completely cover the total number of infected people. These reports do not include the as…
View article: The Role of Autophagy in Interferon/Ribavirin Responders and Non-Responders with Hepatitis C Virus Infection
The Role of Autophagy in Interferon/Ribavirin Responders and Non-Responders with Hepatitis C Virus Infection Open
Background: Hepatitis C virus (HCV) is a significant cause of chronic inflammatory liver diseases. Hepatitis C virus infection is a common disorder worldwide, which has become a significant public health concern. The survival of viruses in…
View article: HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model.
HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model. Open
A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. Mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenviron…
View article: The Synergistic Effect of Fluvastatin and IFN-λ on Peripheral Blood Mononuclear Cells of Chronic Hepatitis C Virus (HCV) Patients with IL-28B rs12979860 CC Genotype
The Synergistic Effect of Fluvastatin and IFN-λ on Peripheral Blood Mononuclear Cells of Chronic Hepatitis C Virus (HCV) Patients with IL-28B rs12979860 CC Genotype Open
There is a relationship between the life cycle of the hepatitis C virus (HCV) and the synthesis and hemostasis of lipids as well as lipid metabolism and interferon (IFN) regulatory system. This study aimed to examine the effect of fluvasta…
View article: Listeriolysin O immunogenetic adjuvant enhanced potency of hepatitis C virus NS3 DNA vaccine
Listeriolysin O immunogenetic adjuvant enhanced potency of hepatitis C virus NS3 DNA vaccine Open
Hepatitis C virus (HCV) is a major health problem all over the world. Among HCV proteins, nonstructural protein 3 (NS3) is one of the most promising target for anti‐HCV therapy and a candidate for vaccine design. DNA vaccine is an efficien…
View article: Impact of interplay between autophagy and interferon-alpha in HCV and HCV/HIV infection
Impact of interplay between autophagy and interferon-alpha in HCV and HCV/HIV infection Open
Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are among the most dangerous pathogens globally. Infection with HCV has been reported in a high percentage of HIV patients. Viruses are obligate intracellular pathogens and the…
View article: A Decline in Anti-Core+1 Antibody Titer Occurs in Successful Treatment of Patients Infected with Hepatitis C Virus
A Decline in Anti-Core+1 Antibody Titer Occurs in Successful Treatment of Patients Infected with Hepatitis C Virus Open
Background: Hepatitis C virus (HCV) causes one of the major chronic liver diseases (CLD). Hepatitis C virus- core encoding sequence possesses an overlapping open reading frame (ORF) that expresses a protein called F or core+1. Objectives: …
View article: Combination of virotherapy with VSV and tumor vaccination significantly enhances the efficacy of antitumor therapy
Combination of virotherapy with VSV and tumor vaccination significantly enhances the efficacy of antitumor therapy Open
Oncolytic virotherapy offers the potential to treat tumors both as a single agent and in combination with conventional therapies such as chemotherapy and immunological therapy. Here, we describe an effective treatment regimen which combine…
View article: Autophagy induction regulates influenza virus replication in a time-dependent manner
Autophagy induction regulates influenza virus replication in a time-dependent manner Open
This study revealed that the virus (H1N1) titre was controlled in a time-dependent manner following autophagy induction in host cells. Manipulation of autophagy during the IV life cycle can be targeted both for antiviral aims and for incre…
View article: Autophagy Gene Activity May Act As a Key Factor for Sensitivity of Tumor Cells to Oncolytic Vesicular Stomatitis Virus
Autophagy Gene Activity May Act As a Key Factor for Sensitivity of Tumor Cells to Oncolytic Vesicular Stomatitis Virus Open
It seems that by using some methods for reducing autophagy, it is possible to make tumor cells more sensitive to virotherapy and even other treatments.
View article: Construction and Immunogenicity Analysis of Hepatitis C Virus (HCV) Truncated Non-Structural Protein 3 (NS3) Plasmid Vaccine
Construction and Immunogenicity Analysis of Hepatitis C Virus (HCV) Truncated Non-Structural Protein 3 (NS3) Plasmid Vaccine Open
The pc-NS3 possesses the capacity to express NS3 in the mammalian cell line and demonstrated strong immunogenicity in a murine model. Our primary results demonstrated that the immunogenic truncated region of NS3 could be used as a potentia…