Explanipedia

En Bloc Spondylectomy versus Separation Surgery for Spinal Metastases: A Systematic Review and Meta-Analysis Open

Ahmad Kareem Almekkawi, Ashlesha S Bhojane, Brandon Edelbach, James P. Caruso, Salah G. Aoun , et al. · 2025

Outcomes are comparable between en bloc spondylectomy and separation surgery with SBRT for spinal metastases, but en bloc techniques lead to a higher complication rate. Additional rigorous comparative effectiveness research is needed to re…

Preoperative anemia is associated with prolonged hospital stay and increased facility discharges after glioblastoma resection Open

Ahmad Kareem Almekkawi, Ammar Adenwalla, James P. Caruso, William H. Hicks, Benjamin Rail , et al. · 2025

Background Despite numerous operative and non-operative treatment modalities, patients with glioblastoma (GBM) have a dismal prognosis. Identifying predictors of survival and recurrence is an essential strategy for guiding treatment decisi…

Author Correction: Recording of pig neuronal activity in the comparative context of the awake human brain Open

Aksharkumar Dobariya, Tarek Y. El Ahmadieh, Levi B. Good, Ana G. Hernández-Reynoso, Vikram Jakkamsetti , et al. · 2024

Leiomyogenic Tumor of the Spine: A Systematic Review Open

Abdurrahman F. Kharbat, Kishore Balasubramanian, Kiran Sankarappan, Ryan D. Morgan, Khawaja Muthammir Hassan , et al. · 2024

The study cohort consisted of 83 patients with a mean age of 49.55 (SD 13.72) with a female preponderance (60 patients). Here, 32.14% of patients had primary LTS; the remaining were metastases. Clinical presentation included nonspecific ba…

Outcomes Following Early Postoperative Adjuvant Radiosurgery for Brain Metastases Open

Evan D. Bander, Tarek Y. El Ahmadieh, Justin Chen, Anne S. Reiner, Samantha Brown , et al. · 2023

Importance Adjuvant stereotactic radiosurgery (SRS) enhances the local control of resected brain metastases (BrM). However, the risks of local failure (LF) and potential for posttreatment adverse radiation effects (PTRE) after early postop…

Orbital Exenteration for Craniofacial Lesions: A Systematic Review and Meta-Analysis of Patient Characteristics and Survival Outcomes Open

Jumanah Qedair, Ali S. Haider, Kishore Balasubramanian, Paolo Palmisciano, Taimur Hassan , et al. · 2023

Background: The outcomes of orbital exenteration (OE) in patients with craniofacial lesions (CFLs) remain unclear. The present review summarizes the available literature on the clinical outcomes of OE, including surgical outcomes and overa…

Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC) Open

Muhammed Shariff, Aksharkumar Dobariya, Obada Albaghdadi, Jacob Awkal, Hala Moussa , et al. · 2023

The Use of Circulating Tumor DNA Assays and Liquid Biopsies in Pediatric Brain Tumors: A Review Open

Doaa M. Abdalla, Eiman M. Abdalla, Ahmad Kareem Almekkawi, Rasha Elsayed Ahmed, Tanya Minasian , et al. · 2023

Pediatric brain tumors are the leading cause of cancer-related death in children. Diagnosis cur-rently relies on surgical biopsy to obtain tumor tissue for histological analysis. There is a great need for less invasive approaches to molecu…

Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC) Open

Muhammed Shariff, Aksharkumar Dobariya, Obada Albaghdadi, Jacob Awkal, Hala Moussa , et al. · 2023

Selective vascular access to the brain is desirable in metabolic tracer, pharmacological and other studies aimed to characterize neural properties in isolation from somatic influences from chest, abdomen or limbs. However, current methods …

Postradiosurgery cystic degeneration in brain metastases causing delayed and potentially severe sequelae: systematic review and illustrative cases Open

Alexandra Giantini-Larsen, Zaki Abou-Mrad, Jacob L. Goldberg, Tarek Y. El Ahmadieh, Kathryn Beal , et al. · 2023

BACKGROUND Cystic postradiation degeneration has previously been described in the literature as a rare but potentially severe complication after central nervous system (CNS) irradiation for vascular malformations. Limited cases have been r…

Transfusion Guidelines in Traumatic Brain Injury: A Systematic Review and Meta-Analysis of the Currently Available Evidence Open

Eric Y. Montgomery, Umaru Barrie, Yves Jordan Kenfack, Derrek Edukugho, James P. Caruso , et al. · 2022

Our study aims to provide a synthesis of the best available evidence on the hemoglobin (hgb) red blood cell (RBC) transfusion thresholds in adult traumatic brain injury (TBI) patients, as well as describing the risk factors and outcomes as…

Author Correction: Recording of pig neuronal activity in the comparative context of the awake human brain Open

Aksharkumar Dobariya, Tarek Y. El Ahmadieh, Levi B. Good, Ana G. Hernández-Reynoso, Vikram Jakkamsetti , et al. · 2022

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes Open

Othman Bin-Alamer, Lokeshwar S. Bhenderu, Paolo Palmisciano, Kishore Balasubramanian, Prashant Upadhyay , et al. · 2022

Background: Infratemporal fossa (ITF) tumors represent various pathologies and are seldom described in the literature, reflecting their rarity. Here we review the literature on tumors invading ITF and describe patient characteristics, trea…

Patient-Reported Outcomes in Endoscopic Endonasal Skull Base Surgery Open

Rabih Bou Nassif, Zaki Abou-Mrad, Tarek Y. El Ahmadieh, Viviane Tabar, Marc A. Cohen · 2022

Recording of pig neuronal activity in the comparative context of the awake human brain Open

Aksharkumar Dobariya, Tarek Y. El Ahmadieh, Levi B. Good, Ana G. Hernández-Reynoso, Vikram Jakkamsetti , et al. · 2022

Neoadjuvant Stereotactic Radiotherapy for Brain Metastases: Systematic Review and Meta-Analysis of the Literature and Ongoing Clinical Trials Open

Paolo Palmisciano, Gianluca Ferini, Ramlah Khan, Othman Bin-Alamer, Giuseppe Emmanuele Umana , et al. · 2022

Background: Brain metastases (BMs) carry a high morbidity and mortality burden. Neoadjuvant stereotactic radiotherapy (NaSRT) has shown promising results. We systematically reviewed the literature on NaSRT for BMs. Methods: PubMed, EMBASE,…

Adenoid Cystic Carcinoma (ACC) Infiltrating the Skull Base: A Systematic Review of Clinical Characteristics and Management Strategies Open

Othman Bin-Alamer, Ali S. Haider, Adhiraj Chaudhary, Kishore Balasubramanian, Tessa Breeding , et al. · 2022

Background/Aim: To systematically review the patient characteristics and management approaches of adenoid cystic carcinoma (ACC) infiltrating the skull base. Materials and Methods: According to PRISMA guidelines, PubMed, Scopus, and Cochra…

Integrated Multidisciplinary Brain Metastasis Care Reduces Patient Visits and Shortens Time to Adjuvant Irradiation Open

Nelson S. Moss, Tarek Y. El Ahmadieh, Samantha Brown, Justin Chen, Brandon S. Imber , et al. · 2022

PURPOSE: Timely surgical cavity stereotactic radiosurgery (SRS) is an important adjuvant to brain metastasis resection, with earlier treatment associated with less frequent recurrence. The logistical complexity of treatment organization, h…

Craniopharyngiomas Invading the Ventricular System: A Systematic Review Open

Paolo Palmisciano, Kurtis Young, Maya Ogasawara, Omid Yousefi, Christian Ogasawara , et al. · 2022

CP-Vs are uncommon and challenging entities. Surgical resection is feasible, but patient-tailored selection of open/endoscopic approaches is necessary to achieve optimal outcomes and minimize complication risks.

MMAP-06 INTEGRATED TEAM-BASED BRAIN METASTASIS CARE REDUCES PATIENT VISITS AND SHORTENS TIME TO ADJUVANT IRRADIATION Open

Nelson S. Moss, Tarek Y. El Ahmadieh, Samantha Brown, Justin Chen, Brandon S. Imber , et al. · 2022

PURPOSE Timely surgical cavity stereotactic radiosurgery (SRS) is an important adjuvant to brain metastasis resection, with earlier treatment associated with less frequent recurrence. The logistical complexity of treatment organization, ho…

Optimizing Door-to-Groin Puncture Time: The Mayo Clinic Experience Open

India Rangel, Paolo Palmisciano, Vanesa Vanderhye, Tarek Y. El Ahmadieh, Waseem Wahood , et al. · 2022

Computed tomography flow modifications produced the largest and most consistent reduction in the DTP time. However, the reduction in the DTP time across all the studies suggests that any systematic protocol aimed at reducing the DTP time c…

Gliomas Infiltrating the Corpus Callosum: A Systematic Review of the Literature Open

Paolo Palmisciano, Gianluca Ferini, Gina Watanabe, Christian Ogasawara, Emal Lesha , et al. · 2022

Background: Gliomas infiltrating the corpus callosum (G-I-CC) majorly impact patient quality-of-life, but maximally safe tumor resection is challenging. We systematically reviewed the literature on G-I-CC. Methods: PubMed, EMBASE, Scopus, …

Imaging characteristics of 4th ventricle subependymoma Open

Ali S. Haider, Tarek Y. El Ahmadieh, Maryam Haider, Kimmo J. Hatanpaa, Marco C. Pinho , et al. · 2022

Purpose Subependymomas located within the 4th ventricle are rare, and the literature describing imaging characteristics is sparse. Here, we describe the clinical and radiological characteristics of 29 patients with 4th ventricle subependym…

Development and Internal Validation of the Postoperative Analgesic Intake Needs Score: A Predictive Model for Post-Operative Narcotic Requirement after Spine Surgery Open

Zachary D. Johnson, Scott Connors, Zachary Christian, Olatunde Badejo, Emmanuel Adeyemo , et al. · 2022

Study Design Retrospective Cohort. Objective The aim of this study was to develop a clinical tool to pre-operatively risk-stratify patients undergoing spine surgery based on their likelihood to have high postoperative analgesic requirement…

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes Open

Paolo Palmisciano, Christian Ogasawara, Chibueze D. Nwagwu, Othman Bin-Alamer, Aditya Gupta , et al. · 2022

Orbital Metastases: A Systematic Review of Clinical Characteristics, Management Strategies, and Treatment Outcomes Open

Paolo Palmisciano, Gianluca Ferini, Christian Ogasawara, Waseem Wahood, Othman Bin-Alamer , et al. · 2021

Background: Orbital metastases often lead to severe functional impairment. The role of resection, orbital exenteration, and complementary treatments is still debated. We systematically reviewed the literature on orbital metastases. Methods…

Primary Skull Base Chondrosarcomas: A Systematic Review Open

Paolo Palmisciano, Ali S. Haider, Mohammadmahdi Sabahi, Chibueze D. Nwagwu, Othman Bin-Alamer , et al. · 2021

Background: Primary skull base chondrosarcomas (SBCs) can severely affect patients’ quality of life. Surgical-resection and radiotherapy are feasible but may cause debilitating complications. We systematically reviewed the literature on pr…

The Role of Immune Checkpoint Inhibitors in Leptomeningeal Disease: A Systematic Review Open

Paolo Palmisciano, Ali S. Haider, Chibueze D. Nwagwu, Waseem Wahood, Kenny Yu , et al. · 2021

ICI therapy is well-tolerated in patients with LMD, but concurrent steroids may worsen survival.

Large Animal Models of Glioma: Current Status and Future Prospects Open

William H. Hicks, Cylaina Bird, Mark N. Pernik, Ali S. Haider, Aksharkumar Dobariya , et al. · 2021

Enhanced understanding of the molecular features of glioma has led to an expansion of murine glioma models and successful preclinical studies. However, clinical trials continue to have a high cost, extended production time, and low proport…

Blood preservation techniques in complex spine surgery: Illustrative case and review of therapeutic options Open

James P. Caruso, Mark N. Pernik, Zachary D. Johnson, Tarek Y. El Ahmadieh, Babatunde Ogunnaike , et al. · 2021

Background: Complex spine surgery predisposes patients to substantial levels of blood loss, which can increase the risk of surgical morbidity and mortality. Case Description: A 29-year-old achondroplastic male required thoracolumbar deform…

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