Tarek Ziad Arabi
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View article: Understanding pleuropulmonary blastoma: A SEER-based analysis of clinical characteristics, treatment patterns, and survival outcomes
Understanding pleuropulmonary blastoma: A SEER-based analysis of clinical characteristics, treatment patterns, and survival outcomes Open
Pleuropulmonary blastoma (PPB) is a rare and aggressive pediatric malignancy originating from the pleuropulmonary mesenchyme. PPB poses significant clinical challenges due to its variable presentation, rapid progression, and poor prognosis…
View article: Kidney transplantation and statins effects on dyslipidemia in kidney transplant recipients
Kidney transplantation and statins effects on dyslipidemia in kidney transplant recipients Open
Introduction: Dyslipidemia is very common after kidney transplantation (KTx), and it has been reported in up to 75% of KTx recipients (KTRs). Hence, statins are commonly used to control lipid levels post-KTx. Studies examining dyslipidemia…
View article: Genome-wide methylation and copy number variation analysis of medulloblastoma in a Saudi Arabian pediatric population
Genome-wide methylation and copy number variation analysis of medulloblastoma in a Saudi Arabian pediatric population Open
Medulloblastoma represents the most common malignant brain tumor in children, characterized by distinct molecular variants that suggest varied prognosis and treatment responses. Genome-wide methylation profiling could be used to characteri…
View article: Survival outcomes and prognostic factors in spindle cell variants of squamous cell carcinoma: a machine learning analysis of 1086 patients from the SEER database
Survival outcomes and prognostic factors in spindle cell variants of squamous cell carcinoma: a machine learning analysis of 1086 patients from the SEER database Open
Background: Spindle cell variants of squamous cell carcinoma represent rare and aggressive malignancies with poorly understood prognostic factors and treatment outcomes. This study leverages machine learning approaches alongside traditiona…
View article: Association between blood pressure in the first-year post-kidney transplantation and pre-transplant coronary calcium scoring: a retrospective cohort study
Association between blood pressure in the first-year post-kidney transplantation and pre-transplant coronary calcium scoring: a retrospective cohort study Open
Background: End-stage kidney disease is often associated with calcification of the arteries, including the coronaries. Currently, it is unclear whether the coronary calcium score (CCS) correlates with blood pressure (BP) changes in kidney …
View article: Prognostic factors influencing overall and cancer-specific survival in Ewing sarcoma: an analysis of 4242 cases from the SEER database
Prognostic factors influencing overall and cancer-specific survival in Ewing sarcoma: an analysis of 4242 cases from the SEER database Open
Introduction: Ewing sarcoma is a rare, aggressive malignancy primarily affecting children and young adults, characterized by significant clinical variability and complex prognostic factors. Methods: In this study, we analyzed data from 424…
View article: Effectiveness of PCSK9 inhibitors in homozygous familial hypercholesterolemia: insights from a Saudi Arabia genetic population
Effectiveness of PCSK9 inhibitors in homozygous familial hypercholesterolemia: insights from a Saudi Arabia genetic population Open
Homozygous familial hypercholesterolemia (HoFH) poses significant cardiovascular risk due to severely elevated low density lipoprotein choleterol (LDL-C) levels. While Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have …
View article: Nationwide retrospective study on the prevalence and prognostic factors of NUT carcinoma in the United States
Nationwide retrospective study on the prevalence and prognostic factors of NUT carcinoma in the United States Open
Background: Nuclear protein of the testis (NUT) carcinoma (NC) is a rare and exceedingly aggressive neoplasm, typically presenting as midline tumors such as mediastinal, thoracic, or sinonasal tumors, but can also be seen in other location…
View article: Outcomes and prognostic factors of tonsillar Kaposi sarcoma in the United States SEER Database
Outcomes and prognostic factors of tonsillar Kaposi sarcoma in the United States SEER Database Open
Tonsillar Kaposi sarcoma (KS) is an extremely rare manifestation of KS, a neoplasm associated with human herpesvirus-8 and often linked to immunocompromised individuals. This study aims to analyze the outcomes and prognostic factors of ton…
View article: Survival outcomes and prognostic factors in glassy cell carcinoma: a retrospective analysis of the SEER database from 1992 to 2021
Survival outcomes and prognostic factors in glassy cell carcinoma: a retrospective analysis of the SEER database from 1992 to 2021 Open
Glassy cell carcinoma (GCC) is a rare, highly aggressive subtype of poorly differentiated adenocarcinoma, primarily affecting the cervix but also reported in other anatomical sites such as the lung, pancreas, and uterus. Due to its rarity,…
View article: Immune rejection of human mesenchymal stem cells compared to extracellular vesicles in mice with renal artery stenosis
Immune rejection of human mesenchymal stem cells compared to extracellular vesicles in mice with renal artery stenosis Open
Renal artery stenosis (RAS) is the leading cause of secondary hypertension worldwide. However, current medical and surgical treatment modalities provide minimal benefits for kidney injury. Recent preclinical RAS models have demonstrated pr…
View article: Parental measurement and correlation of empathy among families attending pediatric neurology clinics
Parental measurement and correlation of empathy among families attending pediatric neurology clinics Open
A BSTRACT Background: Empathy plays a vital role in optimizing care, demanding its presence in both clinicians and patients within the pediatric context. In this domain, empathy takes on a multidimensional aspect, considering various cogni…
View article: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience Open
View article: Advancements in Cardiac Amyloidosis Treatment
Advancements in Cardiac Amyloidosis Treatment Open
Cardiac amyloidosis (CA) is a progressive condition resulting from the deposition of amyloid fibrils in the heart, which leads to severe diastolic dysfunction and restrictive cardiomyopathy. The disease has two main subtypes: light-chain a…
View article: Risk factors and comorbidities associated with cardiac arrests and medical emergencies in interventional radiology patients
Risk factors and comorbidities associated with cardiac arrests and medical emergencies in interventional radiology patients Open
View article: Deciphering the role of claudins in lung cancer
Deciphering the role of claudins in lung cancer Open
Lung cancer remains a major global health challenge, characterized by aggressive malignancy and poor prognostic outcomes. This review article focuses on the pivotal role of claudins, a family of tight junction proteins, in the pathophysiol…
View article: Assessing the prevalence of generalized anxiety disorder in a multicultural medical education setting in Saudi Arabia during the COVID-19 pandemic
Assessing the prevalence of generalized anxiety disorder in a multicultural medical education setting in Saudi Arabia during the COVID-19 pandemic Open
Introduction Mental health among medical students is an area that has been increasingly garnering world-wide attention. Yet, despite this increased attention, research related to anxiety disorders in Saudi Arabia remain limited. This study…
View article: Cytoreductive Surgery combined with Hyperthermic Intraperitoneal Chemotherapy and Intraoperative Radiation Therapy in the Management of Gastric Cancer: A 10-Year Single Center Experience
Cytoreductive Surgery combined with Hyperthermic Intraperitoneal Chemotherapy and Intraoperative Radiation Therapy in the Management of Gastric Cancer: A 10-Year Single Center Experience Open
Background The rationale behind the use of HIPEC involves targeted elimination of microscopic peritoneal metastasis, a common route for GCa dissemination, thereby improving the overall survival and reducing recurrences. Moreover, the reaso…
View article: Associations between total, free and bioavailable 25-hydroxyvitamin D forms with adiponectin and irisin in maternal-neonatal pairs at birth from Greece
Associations between total, free and bioavailable 25-hydroxyvitamin D forms with adiponectin and irisin in maternal-neonatal pairs at birth from Greece Open
Background Apart from the well-established skeletal effects, v itamin D has been explored as a secretagogue influencing various adipokines, including adiponectin and irisin. Recent evidence suggests that specific forms of 25-Hydroxyvitamin…
View article: MDB-22. DECIPHERING MEDULLOBLASTOMA’S MOSAIC: UNVEILING SUBGROUP CLASSIFICATION THROUGH METHYLATION PROFILING
MDB-22. DECIPHERING MEDULLOBLASTOMA’S MOSAIC: UNVEILING SUBGROUP CLASSIFICATION THROUGH METHYLATION PROFILING Open
BACKGROUND Medulloblastoma represents the most prevalent malignant brain tumor in children, posing significant treatment challenges despite advances in multimodal therapies. The heterogeneity of medulloblastomas necessitates precise classi…
View article: Trends in genitourinary cancer mortality in the United States: analysis of the CDC-WONDER database 1999–2020
Trends in genitourinary cancer mortality in the United States: analysis of the CDC-WONDER database 1999–2020 Open
Introduction Sociodemographic disparities in genitourinary cancer-related mortality have been insufficiently studied, particularly across multiple cancer types. This study aimed to investigate gender, racial, and geographic disparities in …
View article: The Effectiveness of Denosumab in Middle Eastern Patients With Giant Cell Tumor of the Bone: A Single-Center, Retrospective Study
The Effectiveness of Denosumab in Middle Eastern Patients With Giant Cell Tumor of the Bone: A Single-Center, Retrospective Study Open
Denosumab does not seem to provide superior long-term outcomes compared to surgery alone. Although our findings are generally consistent with other studies in the literature, larger long-term studies are needed to confirm our findings.
View article: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gallbladder cancer: a case report
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gallbladder cancer: a case report Open
Gallbladder cancer (GBC) is a rare and highly aggressive malignancy, often characterized by nonspecific clinical presentations and late diagnosis, which contribute to its poor prognosis. It is commonly detected at advanced stages, leading …
View article: Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persistent Hyperparathyroidism: A Retrospective Study
Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persistent Hyperparathyroidism: A Retrospective Study Open
BACKGROUND Secondary hyperparathyroidism and coronary calcifications are common complications in chronic kidney disease. However, the relation between coronary calcium score (CCS) and persistent hyperparathyroidism (pHPT) after kidney tran…
View article: (033) Artificial Intelligence ChatGPT and GPT4 Performance on Male and Female Sexual Dysfunction, Sexually Transmitted Infection, and Male Factor Infertility in the 2019 to 2023 American Urological Association Self-Assessment Study Programs
(033) Artificial Intelligence ChatGPT and GPT4 Performance on Male and Female Sexual Dysfunction, Sexually Transmitted Infection, and Male Factor Infertility in the 2019 to 2023 American Urological Association Self-Assessment Study Programs Open
Introduction Large Language Model (LLM) applications in Medicine are increasing. Chatbots ChatGPT and GPT4 were tested against medical exams. The vetting of these tests as a source of information for both the patient and physician is neede…
View article: Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment
Rare Case of Recurrent Adamantinoma of the Tibia: Limited Efficacy of Pazopanib as a Standalone Treatment Open
BACKGROUND Adamantinoma is a rare low-grade malignant bone tumor, usually found in the tibial diaphysis and metaphysis, with histological similarities to mandibular ameloblastoma. The most effective treatment of recurrent adamantinoma is n…
View article: Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications
Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications Open
Type 2 diabetes mellitus (T2DM) is a rapidly escalating global health concern, with its prevalence projected to increase significantly in the near future. This review delves into the intricate role of epigenetic modifications - including D…
View article: Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease
Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease Open
Neutrophil extracellular traps (NETs) play an essential role in antimicrobial defense. However, NETs have also been shown to promote and mediate a wide spectrum of diseases, including cancer, diabetes mellitus, cardiovascular diseases, and…
View article: Beyond the curriculum: unveiling medical students’ drivers and barriers to research participation at Alfaisal University
Beyond the curriculum: unveiling medical students’ drivers and barriers to research participation at Alfaisal University Open
This article examines the motivating factors and obstacles of extracurricular research in Alfaisal University, Saudi Arabia. The study utilizes a mixed methodology of online surveys and in-person group interviews to gain insights from the …
View article: HbA1c changes in the first year post-kidney transplant and associated risk factors in a Saudi cohort
HbA1c changes in the first year post-kidney transplant and associated risk factors in a Saudi cohort Open
Background: There is limited data about the risk factors of clinically significant glycosylated hemoglobin (HbA1c) change and post-transplant diabetes mellitus (PTDM) in the first year post-kidney transplantation (KT), especially in the Mi…