Tarik Zahr
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View article: Ischemic Injury Drives Nascent Tumor Growth Via Accelerated Hematopoietic Aging
Ischemic Injury Drives Nascent Tumor Growth Via Accelerated Hematopoietic Aging Open
View article: Ischemic Injury Drives Tumor Growth via Accelerated Hematopoietic Aging
Ischemic Injury Drives Tumor Growth via Accelerated Hematopoietic Aging Open
Background Patients with peripheral artery disease have increased risk of cancer development. Aging-associated changes in hematopoietic stem and progenitor cells (HSPCs), including inflammation and increased myelopoiesis, are implicated in…
View article: lncRNA<i>CARINH</i>regulates expression and function of innate immune transcription factor IRF1 in macrophages
lncRNA<i>CARINH</i>regulates expression and function of innate immune transcription factor IRF1 in macrophages Open
The discovery of long non-coding RNAs (lncRNAs) has provided a new perspective on the centrality of RNA in gene regulation and genome organization. Here, we screened for lncRNAs with putative functions in the host response to single-strand…
View article: Targeted delivery of a cationic dendrimer with a plaque-homing peptide for the treatment of atherosclerosis
Targeted delivery of a cationic dendrimer with a plaque-homing peptide for the treatment of atherosclerosis Open
View article: Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery
Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery Open
View article: HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells
HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells Open
Background Cholesterol-loading of mouse aortic vascular smooth muscle cells (mVSMCs) downregulates miR-143/145 , a master regulator of the contractile state downstream of TGFβ signaling. In vitro, this results in transitioning from a contr…
View article: PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction
PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction Open
Aging and obesity are the two prominent driving forces of metabolic dysfunction, yet the common underlying mechanisms remain elusive. PPARγ, a central metabolic regulator and primary drug target combatting insulin resistance, is hyperacety…
View article: Uncoupling Lipid Synthesis from Adipocyte Development
Uncoupling Lipid Synthesis from Adipocyte Development Open
Obesity results from the expansion of adipose tissue, a versatile tissue regulating energy homeostasis, adipokine secretion, thermogenesis, and inflammation. The primary function of adipocytes is thought to be lipid storage through lipid s…
View article: PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia
PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia Open
Background: Atherosclerosis is a medical urgency manifesting at the onset of hypercholesterolemia and is associated with aging. Activation of PPARγ (peroxisome proliferator-activated receptor γ) counteracts metabolic dysfunction influenced…
View article: PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms Open
Systemic glucose metabolism and insulin activity oscillate in response to diurnal rhythms and nutrient availability with the necessary involvement of adipose tissue to maintain metabolic homeostasis. However, the adipose‐intrinsic regulato…
View article: Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity
Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity Open
Obesity is characterized by chronic, low-grade inflammation, which is driven by macrophage infiltration of adipose tissue. PPARγ is well established to have an anti-inflammatory function in macrophages, but the mechanism that regulates its…
View article: Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation
Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation Open
Acyl-CoA synthetase 1 (ACSL1) is an enzyme that converts fatty acids to acyl-CoA-derivatives for lipid catabolism and lipid synthesis in general and can provide substrates for the production of mediators of inflammation in monocytes and ma…
View article: The polarizable and reprogrammable identity of Kupffer cells in Nonalcoholic Steatohepatitis
The polarizable and reprogrammable identity of Kupffer cells in Nonalcoholic Steatohepatitis Open
Kupffer cells (KCs) are the resident macrophages of the liver with similar origins to myeloid-derived macrophages. Once differentiated, KCs exhibit distinct cellular machinery capable of longevity and self-renewal, making them a crucial pl…
View article: Adipokines, adiposity, and atherosclerosis
Adipokines, adiposity, and atherosclerosis Open
View article: Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation
Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation Open
Acyl-CoA synthetase 1 (ACSL1) is an enzyme that converts fatty acids to acyl-CoA-derivatives for use in both lipid catabolism and lipid synthesis, including of arachidonic acid mediators that promote inflammation. ACSL1 has also been linke…