Tarja Malm
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View article: Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage Open
Frontotemporal dementia (FTD) is the second most common cause of dementia in patients under 65 years, characterized by diverse clinical symptoms, neuropathologies, and genetic background. Synaptic dysfunction is suggested to play a major r…
View article: Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation ( <scp>TSPO</scp> availability) in monozygotic twin pairs discordant for <scp>BMI</scp> —Exercise training reverses increased brain activity
Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation ( <span>TSPO</span> availability) in monozygotic twin pairs discordant for <span>BMI</span> —Exercise training reverses increased brain activity Open
Aims Obesity is associated with increased insulin‐stimulated brain glucose uptake (BGU) which is opposite to decreased GU observed in peripheral tissues. Increased BGU was shown to be reversed by weight loss and exercise training, but the …
View article: Microglial involvement in autism spectrum disorder: insights from human data and iPSC models
Microglial involvement in autism spectrum disorder: insights from human data and iPSC models Open
Autism spectrum disorder (ASD) presents a range of lifelong challenges in social communication, repetitive behaviors, and restricted interests, affecting over 2% of the preschool population. Early neurodevelopmental disruptions, particular…
View article: Oxidative modulation of Piezo1 channels
Oxidative modulation of Piezo1 channels Open
View article: Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform
Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform Open
Background Microglia and astrocytes are central mediators of neuroinflammation in several neurodegenerative diseases. Their intricate crosstalk and contributions to pathogenesis remain elusive, highlighting the need for innovative in vitro…
View article: Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease‐related dementia
Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease‐related dementia Open
INTRODUCTION Red blood cells (RBCs) are crucial for oxygen delivery to active tissues and endure significant mechanical forces in the microcirculatory bed. The enrichment of mechanosensitive Piezo1 channels, linked to the cytoskeleton, aid…
View article: Correction: Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU‑005 reduces ex vivo cortical spreading depression
Correction: Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU‑005 reduces ex vivo cortical spreading depression Open
View article: Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression
Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression Open
View article: Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab
Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab Open
Objective We have established a comprehensive sample handling protocol designed for the multiscale assessment of epileptogenic tissue. This protocol aims to identify novel therapeutic targets and enhance the diagnosis and stratification of…
View article: Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling
Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling Open
Traffic-related ultrafine particles (UFPs) are an emerging health concern affecting the brain and increasing the risk of Alzheimer's disease (AD). PI3K/AKT signaling is known to contribute to neuronal survival and to be altered in AD. The …
View article: Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family
Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family Open
View article: Ex vivo massively multidimensional diffusion-relaxation correlation MRI: scan-rescan reproducibility and caveats
Ex vivo massively multidimensional diffusion-relaxation correlation MRI: scan-rescan reproducibility and caveats Open
Massively multidimensional diffusion-relaxation correlation MRI (MMD-MRI) provides information beyond the traditional voxel-averaged metric that may better characterize the microstructural characteristics of biological tissues. MMD-MRI rep…
View article: The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions Open
View article: Microelectrode array scaled for human hippocampal slices
Microelectrode array scaled for human hippocampal slices Open
Temporal lobe epilepsy (TLE) is a prevalent neurological disorder characterized by recurrent seizures originating from the cortex, amygdala and especially hippocampus. While two-thirds of TLE patients achieve seizure control through medica…
View article: Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level
Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level Open
Determining the structure‐function relationships of protein aggregates is a fundamental challenge in biology. These aggregates, whether formed in vitro, within cells, or in living organisms, present significant heterogeneity in their molec…
View article: Oxidative Modulation of Piezo1 Channels
Oxidative Modulation of Piezo1 Channels Open
View article: Molecular determinants of protein pathogenicity at the single-aggregate level
Molecular determinants of protein pathogenicity at the single-aggregate level Open
Determining the structure-function relationships of protein aggregates is a fundamental challenge in biology. These aggregates, whether formed in vitro , within cells, or in living organisms, present significant heterogeneity in their mole…
View article: Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia Open
Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson's disease (PD). One of the hallmarks of PD …
View article: Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI
Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI Open
Background/Objectives: Obesity impairs intestinal glucose uptake (GU) (intestinal uptake of circulating glucose from blood) and alters gut microbiome. Exercise improves intestinal insulin-stimulated GU and alters microbiome. Genetics influ…
View article: Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI
Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI Open
Obesity and sedentarism are associated with increased liver and pancreatic fat content (LFC and PFC, respectively) as well as impaired organ metabolism. Exercise training is known to decrease organ ectopic fat but its effects on organ meta…
View article: <i>C9orf72</i>repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesicles
<i>C9orf72</i>repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesicles Open
C9orf72 hexanucleotide repeat expansion (HRE) is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The role of microglia in these C9orf72 HRE-associated diseases is understudied. To elucidate effects of C9…
View article: Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease
Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease Open
View article: Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease Open
View article: Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia Open
Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson’s disease. One of the hallmarks of Parkinso…
View article: Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage Open
Frontotemporal dementia (FTD) is the second most common cause of dementia in patients under 65 years, characterized by diverse clinical symptoms, neuropathologies, and genetic background. Synaptic dysfunction is suggested to play a major r…
View article: StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling
StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling Open
The Patient Similarity Network paradigm implies modeling the similarity between patients based on specific data. The similarity can summarize patients’ relationships from high-dimensional data, such as biological omics. The end PSN can und…
View article: The critical role of isomiRs in accurate differential expression analysis of miRNA-seq data
The critical role of isomiRs in accurate differential expression analysis of miRNA-seq data Open
MicroRNAs (miRNAs) are crucial for the regulation of gene expression and are promising biomarkers and therapeutic targets. miRNA isoforms (isomiRs) differ in their start/end offsets, which can impact the target gene selection and non-canon…
View article: Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)
Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT) Open
Recent studies have shown that obesity and insulin resistance are associated with increased insulin-stimulated glucose uptake (GU) in the brain. Thus, insulin sensitivity seems to work differently in the brain compared to the peripheral ti…
View article: Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology Open
View article: Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia Open
Microglia are brain resident immune cells and maintain proteostasis and cellular homeostasis there. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson’s disease. One of the hallmarks of Par…