Taro Kariya
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View article: The effect of intraoperative excessive bleeding on the pharmacokinetics of ampicillin and sulbactam in recipients of living donor liver transplantation in Japan
The effect of intraoperative excessive bleeding on the pharmacokinetics of ampicillin and sulbactam in recipients of living donor liver transplantation in Japan Open
Objective Guidelines recommend redosing with intravenous prophylactic antibiotics when excessive bleeding exceeds 1500 mL during surgery based on the pharmacokinetics data of cefazolin. However, the necessity for redosing of other antibiot…
View article: In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performance
In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performance Open
Although the benefits of β-1 adrenergic receptor (ADRB1) blockade to cardiovascular disease are established, in vivo role for cardiomyocyte ADRB1 remains undetermined. Generating cardiomyocyte-specific ADRB1 knockout mice, we show that ADR…
View article: Potential of right ventricular function assessment with echocardiography in transcatheter aortic valve replacement:
Potential of right ventricular function assessment with echocardiography in transcatheter aortic valve replacement: Open
View article: A minimally invasive swine model of chronic kidney disease-associated heart failure
A minimally invasive swine model of chronic kidney disease-associated heart failure Open
Cardiac pathological changes consistent with heart failure with preserved ejection fraction can be induced in a large animal model by serial and titrated renal embolization of kidneys with autologous clot, leading to severe renal dysfuncti…
View article: AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine
AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine Open
Adeno-associated virus-based gene therapy is a promising avenue in heart failure treatment, but has shown limited cardiac virus uptake in humans, requiring new approaches for clinical translation. Using a Yorkshire swine ischemic heart fai…
View article: Endothelial oestrogen–myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload
Endothelial oestrogen–myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload Open
Aims Oestrogen exerts beneficial cardiovascular effects by binding to specific receptors on various cells to activate nuclear and non-nuclear actions. Oestrogen receptor α (ERα) non-nuclear signalling confers protection against heart failu…
View article: Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis
Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis Open
Aims Vein grafts are used for many indications, including bypass graft surgery and arteriovenous fistula (AVF) formation. However, patency following vein grafting or AVF formation is suboptimal for various reasons, including thrombosis, ne…
View article: Correction: Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
Correction: Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility Open
View article: Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility Open
View article: The New Perspectives Journal of Medicine
The New Perspectives Journal of Medicine Open
东京大学医学部附属医院(以下简称本院)肝切除 术术中的麻醉管理，在长期大量的病例积累过程中，已 经成熟定型，但主要针对开腹手术
View article: 2570. The intraoperative pharmacokinetics of ampicillin and sulbactam and the effect of massive bleeding in recipients of living donor liver transplantation
2570. The intraoperative pharmacokinetics of ampicillin and sulbactam and the effect of massive bleeding in recipients of living donor liver transplantation Open
Background The current guidelines recommend redosing of prophylactic intraoperative antimicrobials based on their half-life or in case of bleeding greater than 1,500 mL. However, data to support this practice is scarce. Orthotopic liver tr…
View article: Identification of an optimal method for echocardiographic right ventricular mass estimation in a swine model of pulmonary hypertension
Identification of an optimal method for echocardiographic right ventricular mass estimation in a swine model of pulmonary hypertension Open
Background Right ventricular (RV) mass and Fulton Index (FI) - the ratio of right to left ventricular mass - are useful markers of RV remodeling and predictors of mortality in pulmonary hypertension (PH). Cardiac magnetic resonance imaging…
View article: Mechanical LV support lowers diastolic LV pressure and prolongs diastolic coronary flow in the infarcted artery
Mechanical LV support lowers diastolic LV pressure and prolongs diastolic coronary flow in the infarcted artery Open
Background Percutaneous left ventricular (LV) assist device provides not only circulatory support but also LV unloading. However, impact of LV unloading on coronary flow and mechanisms by which it is regulated remain unclear. We aimed to e…
View article: Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading
Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading Open
View article: Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury
Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury Open
View article: Ventricular fibrillation during carotid endarterectomy and bailout stenting: a case report
Ventricular fibrillation during carotid endarterectomy and bailout stenting: a case report Open
Background Carotid artery manipulation is not a special technique but reports of intraoperative ventricular fibrillation are rare. The risk of fatal arrhythmias may be hidden behind routine surgical techniques and anesthetic management. We…
View article: Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation
Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation Open
We show different LA structural and functional remodeling patterns between ischemic MR and MR due to leaflet prolapse. Severe ischemic MR was accompanied by extensive LA remodeling, which may be associated with poor clinical outcomes. Our …
View article: Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck
Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck Open
A disappointing number of new therapies for pulmonary hypertension (PH) have been successfully translated to the clinic. Adeno-associated viral (AAV) gene therapy has the potential to treat the underlying pathology of PH, but the challenge…
View article: The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure
The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure Open
Phosphodiesterase 5 inhibition (PDE5i) activates cGMP‐dependent protein kinase (PKG) and ameliorates heart failure; however, its impact on cardiac mitochondrial regulation has not been fully determined. Here, we investigated the role of th…
View article: Time Course Phagocyte Accumulation in the Lung in Murine Mild Sepsis
Time Course Phagocyte Accumulation in the Lung in Murine Mild Sepsis Open
Rationale: Sepsis is a life-threatening organ dysfunction.Even after initial success in cardiovascular rescue, many cases die due to nosocomial infection, especially in the lung.Previously we reported high mortality rate of mice with mild …
View article: Corrigendum: Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics
Corrigendum: Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics Open
[This corrects the article DOI: 10.3389/fcvm.2020.00162.].
View article: Effects of Therapeutic Hypothermia on Normal and Ischemic Heart
Effects of Therapeutic Hypothermia on Normal and Ischemic Heart Open
Therapeutic hypothermia has been used for treating brain injury after out-of-hospital cardiac arrest. Its potential benefit on minimizing myocardial ischemic injury has been explored, but clinical evidence has yet to confirm positive resul…
View article: Targeted delivery of therapeutic agents to the heart
Targeted delivery of therapeutic agents to the heart Open
View article: Endothelial-specific Ablation of Non-nuclear Estrogen Receptor alpha Signaling Deteriorates Vascular Remodelling Response
Endothelial-specific Ablation of Non-nuclear Estrogen Receptor alpha Signaling Deteriorates Vascular Remodelling Response Open
Background and introduction The difference in cardiovascular disease risk between age-matched women and men narrows as transition through menopause in observational studies. Estrogen exerts complex physiological effects via its non-nuclear…
View article: Impaired left ventricular global longitudinal strain is associated with elevated left ventricular filling pressure after myocardial infarction
Impaired left ventricular global longitudinal strain is associated with elevated left ventricular filling pressure after myocardial infarction Open
Strain analysis was performed in 104 pigs after MI, and its relationship to invasive hemodynamic measurements was studied. Impaired longitudinal strain was associated with high ventricular filling pressure independent of LV EF in post-MI s…
View article: Bronchovenous Fistula During Adult Cardiac Surgery: A Case Report
Bronchovenous Fistula During Adult Cardiac Surgery: A Case Report Open
Bronchovenous fistula (BVF) associated with adult cardiac surgery is a rarely reported life-threatening condition. We present a 75-year-old woman who developed a BVF during cardiac surgery. Dense adhesion in the pleural and pericardial cav…
View article: Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics
Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics Open
Background: Coronary artery dissection (CAD) sometimes accompanies unstable hemodynamics and requires mechanical cardiac support. Meanwhile, mechanical cardiac support may influence coronary hemodynamics in CAD. No study has examined the i…
View article: Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis
Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis Open
View article: Rapid spread of COVID-19 in New York and the response of the community
Rapid spread of COVID-19 in New York and the response of the community Open
The first COVID-19 patient in New York (NY) was reported on March 1, 2020. Since then NY has become one of the largest epicenters in the world where the disease has been overwhelming the healthcare system. Here I report how rapidly COVID-1…
View article: Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy
Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy Open
Using genetically engineered mice lacking estrogen receptor-α non-nuclear signaling, this study demonstrated that estrogen receptor-α non-nuclear signaling activated myocardial cyclic guanosine monophosphate-dependent protein kinase G and …