Tarun Singhal
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View article: Nasal administration of Protollin enhances monocyte phagocytosis and decreases CD8+ T cell cytotoxicity in subjects with early Alzheimer’s disease: A phase 1 clinical trial
Nasal administration of Protollin enhances monocyte phagocytosis and decreases CD8+ T cell cytotoxicity in subjects with early Alzheimer’s disease: A phase 1 clinical trial Open
Protollin, a nasal adjuvant, was evaluated in a randomized double-blind phase 1 study of 16 early Alzheimer’s disease (AD) patients to determine safety and to assess its immunomodulatory effects. In a double-blind dose escalation study, su…
View article: Dampening of Microglial Activation With Nasal Foralumab Administration in Moderate Alzheimer’s Disease Dementia
Dampening of Microglial Activation With Nasal Foralumab Administration in Moderate Alzheimer’s Disease Dementia Open
A 78-year-old man with moderate Alzheimer disease (AD) dementia was treated with nasal-foralumab, a fully human anti-CD3 monoclonal antibody, as part of a Food and Drug Administration expanded-access-program, based on previously demonstrat…
View article: Nasal foralumab treatment of PIRA induces regulatory immunity, dampens microglial activation and stabilizes clinical progression in non-active secondary progressive MS
Nasal foralumab treatment of PIRA induces regulatory immunity, dampens microglial activation and stabilizes clinical progression in non-active secondary progressive MS Open
Background Progression independent of relapses (PIRA) is a major therapeutic challenge in multiple sclerosis (MS). Nasal anti-CD3 treats animal models of progressive MS by inducing regulatory T cells (Tregs) that suppress central nervous s…
View article: Fournier’s Gangrene Secondary to Acute Perforated Appendicitis
Fournier’s Gangrene Secondary to Acute Perforated Appendicitis Open
View article: Radiation Proctitis: A Review of Pathophysiology and Treatment Strategies
Radiation Proctitis: A Review of Pathophysiology and Treatment Strategies Open
Radiotherapy (RT) has become an integral part of cancer treatment worldwide; it aims to arrest the uncontrolled growth of tumor cells by using high-energy rays. Radiation proctitis is a known clinical manifestation after the RT regime for …
View article: Comment on “Implementing a no‑drain policy for extraperitoneal colorectal anastomosis in a real‑life setting: analysis of outcomes and surgeons’ adherence”
Comment on “Implementing a no‑drain policy for extraperitoneal colorectal anastomosis in a real‑life setting: analysis of outcomes and surgeons’ adherence” Open
View article: Stigma in Multiple Sclerosis: A Narrative Review of Current Concepts, Measures, and Findings
Stigma in Multiple Sclerosis: A Narrative Review of Current Concepts, Measures, and Findings Open
CE INFORMATION ACTIVITY AVAILABLE ONLINE: To access the article and evaluation online, go to https://www.highmarksce.com/mscare. TARGET AUDIENCE: The target audience for this activity is physicians, advanced practice clinicians, nursing pr…
View article: Glial Activity Load on PET Reveals Persistent “Smoldering” Inflammation in MS Despite Disease-Modifying Treatment
Glial Activity Load on PET Reveals Persistent “Smoldering” Inflammation in MS Despite Disease-Modifying Treatment Open
Purpose of the Report 18 F-PBR06-PET targeting 18-kDa translocator protein can detect abnormal microglial activation (MA) in multiple sclerosis (MS). The objectives of this study are to develop individualized mapping of MA using 18 F-PBR06…
View article: Glial activity load on PET (GALP) reveals persistent ‘smoldering’ inflammation in MS despite disease modifying treatment: [F-18]PBR06 study
Glial activity load on PET (GALP) reveals persistent ‘smoldering’ inflammation in MS despite disease modifying treatment: [F-18]PBR06 study Open
Introduction Cortical grey (CoGM) and white matter (WM) microglial activation (MA) is involved in the pathogenesis of multiple sclerosis (MS). [F-18]PBR06 positron emission tomography (PET) targeting 18kilodalton-translocator protein (TSPO…
View article: 908 Factors Affecting Last Minute Cancellation of Elective General Surgical Cases; Preliminary Findings of a QIP
908 Factors Affecting Last Minute Cancellation of Elective General Surgical Cases; Preliminary Findings of a QIP Open
Introduction Waiting lists for elective general surgeries have been growing steadily over the past few years, with short-notice cancellations affecting both cost and patient safety. There are currently nationwide incentives to cut referral…
View article: Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine
Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine Open
Background There is limited knowledge about T cell responses in patients with multiple sclerosis (MS) after 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine. Objectives Assess the SARS-CoV-2 spike antibo…
View article: Assessment of Microglial Activation in Alzheimer Disease Using 18F-PBR06 PET
Assessment of Microglial Activation in Alzheimer Disease Using 18F-PBR06 PET Open
A 69-year-old woman with progressive short-term memory deficits was diagnosed with Alzheimer disease (MMSE 26/30, CDR 0.5) and underwent PET using 18 F-PBR06, a second-generation 18-kDa translocator protein ligand, targeting brain microgli…
View article: Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline
Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline Open
In older adults with cognitive decline and epilepsy, diagnosing the etiology of cognitive decline is challenging. We identified 6 subjects enrolled in the Imaging Dementia-Evidence of Amyloid Imaging Scanning (IDEAS) study and nonlesional …
View article: State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer’s disease: Challenges and opportunities
State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer’s disease: Challenges and opportunities Open
View article: Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping
Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping Open
View article: Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping
Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping Open
Multiple system atrophy (MSA) is a fatal neurodegenerative disease of unknown etiology characterized by widespread aggregation of the protein alpha-synuclein in neurons and glia. Its orphan status, biological relationship to Parkinson’s di…
View article: Humoral response to COVID-19 vaccination in MS patients on disease modifying therapy: Immune profiles and clinical outcomes
Humoral response to COVID-19 vaccination in MS patients on disease modifying therapy: Immune profiles and clinical outcomes Open
View article: Circulating neurofilament is linked with morbid obesity, renal function, and brain density
Circulating neurofilament is linked with morbid obesity, renal function, and brain density Open
View article: Aseptic Neutrophilic Meningitis With Hypoglycorrhachia Following a Single Ocrelizumab Infusion
Aseptic Neutrophilic Meningitis With Hypoglycorrhachia Following a Single Ocrelizumab Infusion Open
An increasing number of disease-modifying therapies (DMTs) are being approved for treatment of multiple sclerosis (MS).Ocrelizumab is a humanized B cell-depleting monoclonal antibody, recently approved for relapsing and primary progressive…
View article: 318 Management of Incidental Pancreatic Cysts –Are We Adhering to Guidelines?
318 Management of Incidental Pancreatic Cysts –Are We Adhering to Guidelines? Open
Background The majority of pancreatic cysts (PC) are incidentally diagnosed. Most NHS Trusts do not have pathways to manage them. We reviewed the management of incidental PC and adherence to guidelines. Method Data was collected across thr…
View article: AB170. SOH21AS176. The effect of faecal diversion on the nutritional status of patients with complex Crohn’s disease with mass
AB170. SOH21AS176. The effect of faecal diversion on the nutritional status of patients with complex Crohn’s disease with mass Open
View article: AB168. SOH21AS170. Foreign body ingestion: presenting in an unusual way
AB168. SOH21AS170. Foreign body ingestion: presenting in an unusual way Open
Background: This is a case report of 15 years old psychiatric girl with previous history of foreign body ingestion. She presented with very vague symptoms inconclusive for recurrent ingestion. Two ingested vinyl gloves lying in stomach wer…
View article: AB130. SOH21AS022. Diverticular disease and diet: are we doing enough?
AB130. SOH21AS022. Diverticular disease and diet: are we doing enough? Open
Background: Diverticular disease (DD) is a major burden on healthcare systems globally, especially in the western world. DD accounts for the second most common indication for elective colorectal resections, with each resection costing the …
View article: AB131. SOH21AS023. Surgery during COVID: the impact of COVID-19 on emergency procedures in a district general hospital
AB131. SOH21AS023. Surgery during COVID: the impact of COVID-19 on emergency procedures in a district general hospital Open
Background: The COVID-19 pandemic has introduced significant pressure on respiratory physicians, anaesthetists, and hospital bed capacity. But the impact of COVID on other services, especially surgery, hasn't been highlighted during this p…
View article: Widespread Glial Activation in Primary Progressive Multiple Sclerosis Revealed by 18F-PBR06 PET
Widespread Glial Activation in Primary Progressive Multiple Sclerosis Revealed by 18F-PBR06 PET Open
A 64-year-old man with primary progressive multiple sclerosis (Expanded Disability Status Scale 3.5) underwent PET using 18 F-PBR06, a second-generation 18-kDa translocator protein ligand targeting activated brain microglia and astrocytes.…
View article: Ground plan for performing Emergency Surgery in suspected and confirmed COVID-19 patients
Ground plan for performing Emergency Surgery in suspected and confirmed COVID-19 patients Open
Background: Covid-19 crisis has created a huge challenge to the healthcare systems all over the world. Different health policies have been adopted with variable success. This paper aims to provide a practical pathway of managing surgical p…
View article: Regional microglial activation in the substantia nigra is linked with fatigue in MS
Regional microglial activation in the substantia nigra is linked with fatigue in MS Open
Substantia nigra microglial activation is linked to fatigue in MS. Microglial activation across key brain regions may represent a unifying mechanism for MSAF, and further evaluation of neuroimmunologic basis of MSAF is warranted.
View article: Reversible Amnestic Cognitive Impairment in a Patient With Brain Sagging Syndrome
Reversible Amnestic Cognitive Impairment in a Patient With Brain Sagging Syndrome Open
Brain sagging syndrome secondary to intracranial hypotension can present as a reversible cause of dementia mimicking Alzheimer disease and bvFTD.
View article: Correction to: The PET Sandwich: Using Serial FDG-PET Scans with Interval Burst Suppression to Assess Ictal Components of Disease
Correction to: The PET Sandwich: Using Serial FDG-PET Scans with Interval Burst Suppression to Assess Ictal Components of Disease Open
View article: Correction to: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis
Correction to: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis Open