Tashvinder Singh
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View article: Design, synthesis, and anticancer assessment of structural analogues of (<i>E</i>)-1-((3,4,5-trimethoxybenzylidene)amino)-4-(3,4,5-trimethoxyphenyl)imidazo[1,2-<i>a</i>]quinoxaline-2-carbonitrile (6b), an imidazo[1,2-<i>a</i>]quinoxaline-based non-covalent EGFR inhibitor
Design, synthesis, and anticancer assessment of structural analogues of (<i>E</i>)-1-((3,4,5-trimethoxybenzylidene)amino)-4-(3,4,5-trimethoxyphenyl)imidazo[1,2-<i>a</i>]quinoxaline-2-carbonitrile (6b), an imidazo[1,2-<i>a</i>]quinoxaline-based non-covalent EGFR inhibitor Open
Two lead compounds, 5a and 5l, designed on an imidazo[1,2- a ]quinoxaline template, emerged as potent EGFR inhibitors and anti-lung cancer agents.
View article: In Vivo Anticancer Evaluation of 6b, a Non-Covalent Imidazo[1,2-a]quinoxaline-Based Epidermal Growth Factor Receptor Inhibitor against Human Xenograft Tumor in Nude Mice
In Vivo Anticancer Evaluation of 6b, a Non-Covalent Imidazo[1,2-a]quinoxaline-Based Epidermal Growth Factor Receptor Inhibitor against Human Xenograft Tumor in Nude Mice Open
Tyrosine kinase inhibitors are validated therapeutic agents against EGFR-mutated non-small cell lung cancer (NSCLC). However, the associated critical side effects of these agents are inevitable, demanding more specific and efficient target…
View article: Design and Synthesis of Non-Covalent Imidazo[1,2-a]quinoxaline-Based Inhibitors of EGFR and Their Anti-Cancer Assessment
Design and Synthesis of Non-Covalent Imidazo[1,2-a]quinoxaline-Based Inhibitors of EGFR and Their Anti-Cancer Assessment Open
A series of 30 non-covalent imidazo[1,2-a]quinoxaline-based inhibitors of epidermal growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment (against wild type) data of compounds revealed 6b, 7h, 7j, 9a and 9…
View article: Metabolic Adaptations in Cancer Stem Cells
Metabolic Adaptations in Cancer Stem Cells Open
Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer cells with remarkable ability to initiate, propagate, and spread the malignant disease. In addition, they exhibit increased resistance to anticancer the…