Explanipedia

Large language model as clinical decision support system augments medication safety in 16 clinical specialties Open

Jasmine Chiat Ling Ong, Liyuan Jin, Kabilan Elangovan, Gilbert Yong San Lim, Daniel Yan Zheng Lim , et al. · 2025

Large language models (LLMs) have emerged as tools to support healthcare delivery, from automating tasks to aiding clinical decision-making. This study evaluated LLMs as alternative to rule-based alert systems, focusing on their ability to…

Should Cefoxitin Non-Susceptibility in Ceftriaxone-Susceptible E. coli and K. pneumoniae Prompt Concerns Regarding Plasmid-Mediated AmpC Resistance? A Genomic Characterization and Summary of Treatment Challenges in Singapore Open

J.T.W. Foo, Y Y Ong, Clement K. M. Tsui, David Chien Lye, De Partha Pratim , et al. · 2025

Objectives: Plasmid-mediated AmpC beta-lactamases represent a growing clinical concern in Enterobacterales, with challenges in diagnostic approaches, limited data on clinical outcomes, and our incomplete understanding of their regulatory m…

Large Language Model as Clinical Decision Support System Augments Medication Safety in 16 Clinical Specialties Open

Jasmine Chiat Ling Ong, Jin Liyuan, Kabilan Elangovan, Gilbert Yong San Lim, Daniel Yan Zheng Lim , et al. · 2025

Hospitalised patients as stewards of their own antibiotic therapy: a qualitative analysis informing the strategic design of interventions to encourage shared decision-making in tertiary hospital settings in Singapore Open

Huiling Guo, David Chien Lye, Tat Ming Ng, Jyoti Somani, Andrea Lay‐Hoon Kwa , et al. · 2024

Background Shared decision-making (SDM) on antibiotic therapy may improve antibiotic use in tertiary hospitals, but hospitalised patients are apprehensive about being involved in it. Understanding the facilitators and barriers to SDM can i…

Patient’s degree of adherence, challenges & preferences towards medicine taking (PACT) in Singapore Open

Vivien Teo, Benny Kaihui Li, Suat Fern Low, Jing Wen Oh, Kwok Foong Lam , et al. · 2024

Medication nonadherence is a prevalent public health problem that compromises patients’ health outcomes and increases healthcare expenditures.1 Studies in Singapore showed that 25.7%–38.9% of patients are nonadherent.2,3 Studies investigat…

Patient’s degree of adherence, challenges & preferences towards medicine taking (PACT) in Singapore Open

Vivien Teo, Benny Kaihui Li, Suat Fern Low, Jing Wen Oh, Kwok Foong Lam , et al. · 2024

Medication nonadherence is a prevalent public health problem that compromises patients’ health outcomes and increases healthcare expenditures.1 Studies in Singapore showed that 25.7%–38.9% of patients are nonadherent.2,3 Studies investigat…

Antibiotic utilisation and resistance over the first decade of nationally funded antimicrobial stewardship programmes in Singapore acute-care hospitals Open

Tat Ming Ng, Li Wei Ang, Shi Thong Heng, Andrea Lay‐Hoon Kwa, Jia En Wu , et al. · 2023

Objective The aim of this study was to describe the time series of broad-spectrum antibiotic utilisation and incidence of antibiotic-resistant organisms during the implementation of antimicrobial stewardship programmes (ASP) in Singapore. …

National surgical antibiotic prophylaxis guideline in Singapore Open

Wei Teng Gladys Chung, Humaira Shafi, Jonathan Seah, Purnima Parthasarathy, Taweechai Patun , et al. · 2022

Introduction: Institutional surgical antibiotic prophylaxis (SAP) guidelines are in place at all public hospitals in Singapore, but variations exist and adherence to guidelines is not tracked consistently. A national point prevalence surve…

Preferences of Healthcare Professionals on 3D-Printed Tablets: A Pilot Study Open

Odelia Goh, Wei Jiang Goh, Seng Gee Lim, Grace W. Hoo, Raymond Liew , et al. · 2022

An inaugural study was performed to understand the perceptions of healthcare professionals toward the potential benefits of 3D printing in Singapore. This study sought to increase awareness of 3D printing applications for viable clinical a…

Sustaining Antimicrobial Stewardship in a High–Antibiotic Resistance Setting Open

Tat Ming Ng, Shi Thong Heng, Boon Hou Chua, Li Wei Ang, Sock Hoon Tan , et al. · 2022

In this cohort study, concurrent PRF and CDSS were associated with limiting the use of piperacillin-tazobactam and carbapenems while reducing use of other antibiotics.

Antibiotic Therapy in the Treatment of COVID-19 Pneumonia: Who and When? Open

Tat Ming Ng, Sean Wei Xiang Ong, Audrey Yong Xin Loo, Sock Hoon Tan, Hui Lin Tay , et al. · 2022

Background: COVID-19 imposes challenges in antibiotic decision-making due to similarities between bacterial pneumonia and moderate to severe COVID-19. We evaluated the effects of antibiotic therapy on the clinical outcomes of COVID-19 pneu…

The impact of deprescribing interventions on oral proton pump inhibitorutilisation in a Singapore tertiary hospital: A quality improvement initiative Open

Christina Tan, Shi Xun Lee, Tat Ming Ng · 2022

Introduction: Proton pump inhibitors (PPIs) are effective treatments for upper gastrointestinal pathologies and short-term courses are well-tolerated. However, indiscriminate use of PPIs is undesirable due to its potential harms. We implem…

Hospital Pharmacists and Antimicrobial Stewardship: A Qualitative Analysis Open

Lok Hang Wong, Evonne Tay, Shi Thong Heng, Huiling Guo, Andrea Lay‐Hoon Kwa , et al. · 2021

Antimicrobial stewardship programmes (ASPs) in hospitals are predominantly led by specific ASP physicians and pharmacists. Limited studies have been conducted to appreciate non-ASP-trained hospital pharmacists’ perspectives on their roles …

Merits of a harmonised system to classify drug-related problems in Singapore Open

Tat Ming Ng, Wee Chuan Hing, Tsing Yi Koh, Wei Terk Chang, Grace SW Chang , et al. · 2021

Meropenem and piperacillin-tazobactam levels for critical care patients duringempiric therapy Open

Grace Si Ru Hoo, Nathalie Grace Sy Chua, Tat Ming Ng, Lawrence Lee, Andrea Lay‐Hoon Kwa , et al. · 2021

Meropenem and piperacillin

Effects of coronavirus disease 2019 (COVID-19) pandemic on antimicrobial prevalence and prescribing in a tertiary hospital in Singapore Open

Tat Ming Ng, Sock Hoon Tan, Shi Thong Heng, Hui Lin Tay, Min Yi Yap , et al. · 2021

A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) Open

Sock Hoon Tan, Tat Ming Ng, Hui Lin Tay, Min Yi Yap, Shi Thong Heng , et al. · 2020

Performance of Population Pharmacokinetic Models in Predicting Polymyxin B Exposures Open

Vincent H. Tam, Lawrence Lee, Tat Ming Ng, Tze-Peng Lim, Benjamin Pei Zhi Cherng , et al. · 2020

Polymyxin B is the last line of defense in treating multidrug-resistant gram-negative bacterial infections. Dosing of polymyxin B is currently based on total body weight, and a substantial intersubject variability has been reported. We eva…

Effects of Coronavirus Disease 2019 (COVID-19) Pandemic on Antimicrobial Prevalence and Prescribing in a Tertiary Hospital in Singapore Open

Tat Ming Ng, Sock Hoon Tan, Shi Thong Heng, Hui Lin Tay, Min Yi Yap , et al. · 2020

Background: The deployment of antimicrobial stewardship (AMS) teams to deal with the COVID-19 pandemic can lead to a loss of developed frameworks, best practices and leadership resulting in adverse impact on antimicrobial prescribing and r…

Gut Microbiota Modulation: Implications for Infection Control and Antimicrobial Stewardship Open

Glorijoy Shi En Tan, Hui Lin Tay, Sock Hoon Tan, Tau Hong Lee, Tat Ming Ng , et al. · 2020

The human microbiome comprises a complex ecosystem of microbial communities that exist within the human body, the largest and most diverse of which are found within the human intestine. It has been increasingly implicated in human health a…

Effective Antimicrobial StewaRdship StrategIES (ARIES): Cluster Randomized Trial of Computerized Decision Support System and Prospective Review and Feedback Open

Shi Thong Heng, Joshua Wong, Barnaby Edward Young, Hui Lin Tay, Sock Hoon Tan , et al. · 2020

Background Prospective review and feedback (PRF) of antibiotic prescriptions and compulsory computerized decision support system (CDSS) are 2 strategies of antimicrobial stewardship. There are limited studies investigating their combined e…

Risk factors and treatment outcomes of severe Clostridioides difficile infection in Singapore Open

Hui Lin Tay, Angela Chow, Tat Ming Ng, David Chien Lye · 2019

186. Effective Antimicrobial StewaRdship StrategIES (ARIES): Cluster-Randomized Trial of a Clinical Decision Support System to Supplement Antibiotic Prospective Review and Feedback Open

Shi Thong Heng, Joshua Wong, Barnaby Edward Young, Li Min Ling, Brenda Ang , et al. · 2018

BACKGROUND: Prospective review and feedback (PRF) of antibiotic prescriptions is a tenet of antimicrobial stewardship (ASP), but labour intensive. Clinical Decision Support Systems (CDSS) have the potential to automate some of this work. W…

No association between resistance mutations, empiric antibiotic, and mortality in ceftriaxone-resistant Escherichia coli and Klebsiella pneumoniae bacteremia Open

Shi Thong Heng, Swaine L. Chen, Joshua Wong, David Chien Lye, Tat Ming Ng · 2018

Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey Open

Ann Versporten, Peter Zarb, Isabelle Caniaux, Marie-Françoise Gros, Nico Drapier , et al. · 2018

Pharmacist-initiated deprescribing in hospitalised elderly: prevalence and acceptance by physicians Open

Selina Cheong, Tat Ming Ng, Keng Teng Tan · 2017

In our cohort of hospitalised elderly, gastrointestinal agents and supplements were most commonly suggested by pharmacists to be deprescribed and at least three quarters of these interventions were accepted by physicians.

YouTube Video Educational Package Increased Acceptance of Antibiotic Clinical Decision Support System Recommendations Open

Shi Thong Heng, Michelle Tan, Barnaby Edward Young, David Chien Lye, Tat Ming Ng · 2017

Antibiotic clinical decision support systems (CDSS) were implemented to provide stewardship at the point of ordering of broad-spectrum antibiotics (piperacillin-tazobactam and carbapenems). We postulated that a YouTube based educational vi…

Empiric Piperacillin-Tazobactam versus Carbapenems in the Treatment of Bacteraemia Due to Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Open

Tat Ming Ng, Wendy Xiao Ling Khong, Patrick N. A. Harris, Partha Pratim De, Angela Chow , et al. · 2016

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are a common cause of bacteraemia in endemic countries and may be associated with high mortality; carbapenems are considered the drug of choice. Limited data suggest pipe…

Empiric Piperacillin-tazobactam versus Carbapenems in the Treatment of Bacteraemia due to Extended-spectrum Beta-lactamase-producing Enterobacteriaceae Open

Tat Ming Ng · 2016

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are a common cause of bacteraemia in endemic countries and may be associated with high mortality; carbapenems are considered the drug of choice. Limited data suggest pipe…

Potential for Cefazolin as De-escalation Therapy for Klebsiella Pneumoniae Bacteraemia Open

Tat Ming Ng, Christine B. Teng, Ee Ling Lew, Ling Li, Brenda Ang , et al. · 2015

Potential for Cefazolin as De-escalation Therapyfor Klebsiella Pneumoniae Bacteraemia Dear Editor, Klebsiella pneumoniae causes the syndrome of liver abscess, meningitis and endophthalmitis associated with capsular serotype K1/K2, mucoid p…

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