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View article: Perioperative antihypertensive medications and effects on functional decline and mortality in non-cardiac surgery
Perioperative antihypertensive medications and effects on functional decline and mortality in non-cardiac surgery Open
Aims The association between perioperative antihypertensive drugs and mortality as well as physical function in non-cardiac surgeries remains unclear. We aimed to clarify the association between six antihypertensive classes and postoperati…
View article: Association between antihypertensive combinations and postoperative mortality and functional decline: a nationwide survey of Japanese adults undergoing major surgeries
Association between antihypertensive combinations and postoperative mortality and functional decline: a nationwide survey of Japanese adults undergoing major surgeries Open
Background Considering the limited information available regarding the impact of antihypertensive classes on mortality and physical function during hospitalization, we aimed to clarify the impact of six antihypertensive classes, namely thi…
View article: A case of unexpected diagnosis of fibronectin glomerulopathy with histological features of membranoproliferative glomerulonephritis
A case of unexpected diagnosis of fibronectin glomerulopathy with histological features of membranoproliferative glomerulonephritis Open
Fibronectin (FN) glomerulopathy (FNG), a rare autosomal hereditary renal disease, is characterized by proteinuria resulting from the massive accumulation of FN in the glomeruli. It typically affects individuals aged 10–50 years. In this re…
View article: A study on serum Leptin levels and models of Insulin resistance in Gestational Diabetes Mellitus (GDM)
A study on serum Leptin levels and models of Insulin resistance in Gestational Diabetes Mellitus (GDM) Open
Gestational diabetes mellitus (GDM) is characterized by diminished glucose tolerance that manifests during pregnancy.Leptin, a vital adipokine governing several physiological processes, including insulin sensitivity, plays a pivotal role.I…
View article: A Case of Unexpected Diagnosis of Fibronectin Glomerulopathy with Histological Features of Membranoproliferative Glomerulonephritis
A Case of Unexpected Diagnosis of Fibronectin Glomerulopathy with Histological Features of Membranoproliferative Glomerulonephritis Open
Fibronectin (FN) glomerulopathy (FNG), a rare autosomal hereditary renal disease, is characterized by proteinuria resulting from the massive accumulation of FN in the glomeruli. It typically affects individuals aged 10–50 years. In this re…
View article: ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease
ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease Open
AMP-activated protein kinase (AMPK) is a central kinase involved in energy homeostasis. Increased intracellular adenosine monophosphate (AMP) levels result in AMPK activation through the binding of AMP to the γ-subunit of AMPK. Recently, w…
View article: National Trends in Mortality and Urgent Dialysis after Admission for Acute Hypertension in Japan from 2010 through 2019
National Trends in Mortality and Urgent Dialysis after Admission for Acute Hypertension in Japan from 2010 through 2019 Open
Background Despite increasing incidences of hypertension, recent trends in mortality and urgent dialysis following acute hypertension (AHT) remain undetermined. Methods This retrospective observational cohort study evaluated 50,316 hospita…
View article: STUDY OF VARIOUS METHODS FOR DETECTING HLA-B* 57:01 ALLELE IN PLHIV IN EASTERN UP, INDIA.
STUDY OF VARIOUS METHODS FOR DETECTING HLA-B* 57:01 ALLELE IN PLHIV IN EASTERN UP, INDIA. Open
Intro: Abacavir is known to cause fatal hypersensitivity reactions (HSR) in 5-8% of patients. This HSR is linked to the HLA-B*57:01 allele. The gold standard methodology for detecting the HLA-B*57:01 allele is the sequence-based method, wh…
View article: Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease Open
Background: Chronic kidney disease (CKD) accelerates vascular calcification via phenotypic switching of vascular smooth muscle cells (VSMCs). We investigated the roles of circulating small extracellular vesicles (sEVs) between the kidneys …
View article: ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells
ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells Open
Signaling through cAMP/protein kinase A (PKA) promotes endothelial barrier function to prevent plasma leakage induced by inflammatory mediators. The discovery of PKA substrates in endothelial cells increases our understanding of the molecu…
View article: Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study
Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study Open
Admission functional status decline significantly increases in-hospital mortality, length of stay, and costs. Routine assessment of functional status can facilitate the risk prediction of dialysis patients.
View article: LRBA is essential for urinary concentration and body water homeostasis
LRBA is essential for urinary concentration and body water homeostasis Open
Protein kinase A (PKA) directly phosphorylates aquaporin-2 (AQP2) water channels in renal collecting ducts to reabsorb water from urine for the maintenance of systemic water homeostasis. More than 50 functionally distinct PKA-anchoring pro…
View article: ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells
ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells Open
Signaling through cAMP/protein kinase A (PKA) promotes endothelial barrier function to prevent plasma leakage induced by inflammatory mediators. The discovery of novel PKA substrates in endothelial cells has increased our understanding of …
View article: Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study
Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study Open
Background Physicians have long noted a substantial discrepancy between the reasons for hospital admission and ultimate causes of death, particularly among older adults or patients with complex underlying diseases. However, objective data …
View article: Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)
Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A) Open
Urinary uromodulin, secreted by renal tubular cells, protects against urinary tract infections and kidney stones. In contrast, the intracellular accumulation of uromodulin is associated with hypertension and chronic kidney disease. However…
View article: Three hemodialysis patients in which hypercalcemia was induced by the inappropriate use of etelcalcetide under low bone turnover
Three hemodialysis patients in which hypercalcemia was induced by the inappropriate use of etelcalcetide under low bone turnover Open
経口さらには静注投与可能なカルシミメティクスの登場によって慢性腎臓病に伴う二次性副甲状腺機能低下症の治療戦略は近年劇的に変化した．カルシウム（Ca），リン，副甲状腺ホルモン（PTH）の指標範囲値達成率の向上や副甲状腺摘出術の回避という恩恵は極めて大きい．しかしながらわれわれは最近，エテルカルセチドの過剰投与によって高Ca血症を呈した維持血液透析患者の3例を経験した．症例はおのおの38歳男性，62歳男性，66歳女性で，いずれもintact PTH≦21 pg/mLと低回転骨が…
View article: Sodium–calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia
Sodium–calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia Open
The sodium (Na+)-chloride cotransporter (NCC) expressed in the distal convoluted tubule (DCT) is a key molecule regulating urinary Na+ and potassium (K+) excretion. We previously reported that high-K+ load rapidly dephosphorylated NCC and …
View article: intracellular calcium assay v1
intracellular calcium assay v1 Open
This protocol was used for the experiment conducted in " Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia"
View article: Ex vivo mouse kidney slice experiment v1
Ex vivo mouse kidney slice experiment v1 Open
This protocol was used in a manuscript "Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against hyperkalemia.
View article: Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient
Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient Open
Encephalopathy is a rare side effect of cephalosporin treatment. We herein present a case of encephalopathy induced by ceftriaxone, a third-generation cephalosporin, in a patient with renal failure. An 86-year-old woman on maintenance hemo…