Tatiana Polushina
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View article: An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD
An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD Open
Patients with a severe mental disorder report significantly higher levels of childhood trauma (CT) than healthy individuals. Studies have suggested that CT may affect brain plasticity through epigenetic mechanisms and contribute to develop…
View article: Identification of pleiotropy at the gene level between psychiatric disorders and related traits
Identification of pleiotropy at the gene level between psychiatric disorders and related traits Open
View article: Functional analysis of evolutionary human methylated regions in schizophrenia patients
Functional analysis of evolutionary human methylated regions in schizophrenia patients Open
Background Recent studies have implicated variations in DNA methylation in the aetiology of schizophrenia. Genome-wide scans in both brain and blood report differential methylated regions (DMRs) and positions (DMPs) between patients with s…
View article: Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia Open
View article: Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder
Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder Open
View article: Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia
Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia Open
Introduction The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern humans. To explor…
View article: Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes Open
View article: Recently evolved human-specific methylated regions are enriched in schizophrenia signals
Recently evolved human-specific methylated regions are enriched in schizophrenia signals Open
Regions where DNA methylation modifications have changed during recent human evolution show enrichment of association with schizophrenia and possibly with height. Our study further supports the hypothesis that genetic variants conferring r…
View article: Additional file 3: of Recently evolved human-specific methylated regions are enriched in schizophrenia signals
Additional file 3: of Recently evolved human-specific methylated regions are enriched in schizophrenia signals Open
Annotation of enriched DMRs with genes, promoters, CpG islands and enhancers. This file contains detailed annotation of those human-lineage specific DMRs that are enriched for association with schizophrenia markers (except those in the MHC…
View article: Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with <i>GUCY2C</i>-linked familial diarrhea
Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with <i>GUCY2C</i>-linked familial diarrhea Open
Objective: Activating mutations in the GUCY2C gene, which encodes the epithelial receptor guanylate cyclase C, cause diarrhea due to increased loss of sodium chloride to the intestinal lumen. Patients with familial GUCY2C<…
View article: Additional file 2: of Recently evolved human-specific methylated regions are enriched in schizophrenia signals
Additional file 2: of Recently evolved human-specific methylated regions are enriched in schizophrenia signals Open
Annotation of all DMRs with schizophrenia-associated SNPs. This file contains annotation of all the human-lineage specific DMRs that are associated with schizophrenia markers. Details of the various markers present within each DMR is provi…
View article: Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data
Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data Open
View article: An improved hybrid algorithm for multiple change-point detection in array CGH data
An improved hybrid algorithm for multiple change-point detection in array CGH data Open
A human genome is highly structured.Usually, the structure forms regions having patterns of a specific property.It is well-known that analysis of biological sequences is often confronted with measurements for the gene expression levels.Whe…