Т. Yu. Rebrova
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View article: Renal dysfunction in patients with resistant hypertension: association with clinical profile and fat depots
Renal dysfunction in patients with resistant hypertension: association with clinical profile and fat depots Open
Introduction. Chronic kidney disease (CKD) and arterial hypertension (AH), especially its resistant forms, are two closely related and mutually aggravating diseases. The pathophysiology of CKD development in patients with resistant AH is c…
View article: ASSOCIATION OF BETA-ADRENOREACTIVITY OF ERYTHROCYTE MEMBRANES WITH THE SEVERITY OF CHRONIC HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE
ASSOCIATION OF BETA-ADRENOREACTIVITY OF ERYTHROCYTE MEMBRANES WITH THE SEVERITY OF CHRONIC HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE Open
Highlights Beta-adrenoreactivity of erythrocyte membranes (beta-ARM) is an indirect indicator of the activity of the sympathoadrenal system and can act as a marker of the severity of heart failure. In patients with chronic coronary artery …
View article: The significance of the rs1050450 polymorphic variant of the glutathione peroxidase 1 gene in the structure of risk factors for the progression of coronary artery disease
The significance of the rs1050450 polymorphic variant of the glutathione peroxidase 1 gene in the structure of risk factors for the progression of coronary artery disease Open
Glutathione peroxidase 1 (GPX1) plays a crucial role in blocking the involvement of oxidative stress in the formation of atherosclerotic plaques. A polymorphic variant rs1050450 is known, which may be associated with enzyme activity and th…
View article: Expression of the β1-adrenoreceptor gene in patients with atrial fibrillation before and after surgical treatment
Expression of the β1-adrenoreceptor gene in patients with atrial fibrillation before and after surgical treatment Open
Atrial fibrillation (AF) is one of the most frequent cardiac arrhythmias and leads to heart failure. Excessive sympathetic activity aggravates arrhythmogenic processes at the cellular and tissue levels. Hypersympathicotonia leads to desens…
View article: Sympathetic activity markers in patients with resistant hypertension with renal dysfunction
Sympathetic activity markers in patients with resistant hypertension with renal dysfunction Open
Aim. To study the informativeness of sympathetic activity markers and perirenal adipose tissue (PRAT) in assessing renal function decline in patients with resistant hypertension (RH). Material and methods. The study included 63 patients wi…
View article: Beta-adrenergic reactivity of erythrocyte membranes in adolescents with supraventricular and ventricular arrhythmias before and after radiofrequency ablation
Beta-adrenergic reactivity of erythrocyte membranes in adolescents with supraventricular and ventricular arrhythmias before and after radiofrequency ablation Open
Aim. To evaluate β-adrenergic reactivity of erythrocyte membranes (β-ARM) in adolescents with ventricular and supraventricular arrhythmias before and after radiofrequency ablation (RFA) of heart rhythm disturbances. Materials and methods. …
View article: Correlation of β-adrenergic reactivity of erythrocyte membranes with clinical characteristics of patients with coronary artery disease and HF with preserved and reduced ejection fraction
Correlation of β-adrenergic reactivity of erythrocyte membranes with clinical characteristics of patients with coronary artery disease and HF with preserved and reduced ejection fraction Open
Aim . To evaluate β-adrenergic reactivity of erythrocyte membranes (β-ARM) depending on clinical parameters in patients with heart failure (HF) with preserved and reduced ejection fraction (EF), who had prior myocardial infarction. Materia…
View article: The effect of nitric oxide on intestinal tissue damage and erythrocyte membranes when modeling cardiopulmonary bypass and circulatory arrest: an experimental randomized study
The effect of nitric oxide on intestinal tissue damage and erythrocyte membranes when modeling cardiopulmonary bypass and circulatory arrest: an experimental randomized study Open
INTRODUCTION: Ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and circulatory arrest (CA) can lead to the damage of various body systems, including splanchnic. In turn, intestinal damage can lead to the development of multi…
View article: The Correlation of β-Adrenoreactivity of Erythrocyte Membranes with Clinical and Laboratory Parameters in Patients with Resistant Hypertension in the Presence and Absence of Type 2 Diabetes Mellitus
The Correlation of β-Adrenoreactivity of Erythrocyte Membranes with Clinical and Laboratory Parameters in Patients with Resistant Hypertension in the Presence and Absence of Type 2 Diabetes Mellitus Open
The peculiarity of the conjugation of β-adrenoreactivity of membranes (β-ARM) erythrocyte, as an indicator of the state of autonomic regulation of the cardiovascular system, with other clinical and laboratory indicators in drug-resistant a…
View article: Vegetative state assessment in children with supraventricular arrhythmias before and after radiofrequency ablation
Vegetative state assessment in children with supraventricular arrhythmias before and after radiofrequency ablation Open
Aim : To assess erythrocyte membranes β-adrenoreactivity and heart rate variability (HRV) in children with supraventricular arrhythmias initially and in the early period after radiofrequency ablation (RFA). Study method . The study include…
View article: ERYTHROCYTE MEMBRANE ADRENOREACTIVITY IN CHILDREN WITH DRUG-RESISTANT VENTRICULAR EXTRASYSTOLE BEFORE AND AFTER RADIOFREQUENCY ABLATION
ERYTHROCYTE MEMBRANE ADRENOREACTIVITY IN CHILDREN WITH DRUG-RESISTANT VENTRICULAR EXTRASYSTOLE BEFORE AND AFTER RADIOFREQUENCY ABLATION Open
Highlights For children aged 11–15 years with the duration of ventricular arrhythmias from 1 to 2 years, the increased value of β-adrenergic reactivity of erythrocyte membranes (β-ARM) is characteristic in comparison with the group of heal…
View article: Effect of inhaled nitric oxide on intestinal integrity in cardiopulmonary bypass and circulatory arrest simulation: An experimental study
Effect of inhaled nitric oxide on intestinal integrity in cardiopulmonary bypass and circulatory arrest simulation: An experimental study Open
Background and Aims: Cardiopulmonary bypass (CPB) and circulatory arrest (CA) can induce intestinal injury and consequently lead to multiple organ dysfunction. Nitric oxide (NO) has protective effects, but its effect on the intestine has n…
View article: Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension
Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension Open
Aim. To assess the functional state of the sympathetic nervous system according to β-adrenergic reactivity of erythrocyte membranes (EM) in patients with refractory (rfHTN) and resistant hypertension (rHTN) in relation to target organ dama…
View article: Potential Mechanisms for Organoprotective Effects of Exogenous Nitric Oxide in an Experimental Study
Potential Mechanisms for Organoprotective Effects of Exogenous Nitric Oxide in an Experimental Study Open
Performing cardiac surgery under cardiopulmonary bypass (CPB) and circulatory arrest (CA) provokes the development of complications caused by tissue metabolism, microcirculatory disorders, and endogenous nitric oxide (NO) deficiency. This …
View article: Functional ability of mitochondria and mitochondrial genome polymorphism as factors affecting arrhythmogenesis in chronic coronary artery disease
Functional ability of mitochondria and mitochondrial genome polymorphism as factors affecting arrhythmogenesis in chronic coronary artery disease Open
Aim . To investigate functional state of mitochondria and mitochondrial DNA (mtDNA) polymorphism in coronary artery disease (CAD) patients with life-threatening cardiac rhythm disorders (CRD). Methods . We investigated venous blood samples…
View article: Potential role of mitochondrial dysfunction in arrhythmogenesis in coronary artery disease
Potential role of mitochondrial dysfunction in arrhythmogenesis in coronary artery disease Open
Introduction. Coronary artery disease (CAD) continues to be the most common pathology in the structure of cardiovascular diseases over the past decades, both in Russia and around the world. In the normal condition, the mitochondria of all …
View article: Effects of nitric oxide on microviscosity and polarity of erythrocyte membranes in experiment
Effects of nitric oxide on microviscosity and polarity of erythrocyte membranes in experiment Open
Enhancement of methods for protecting target organs during coronary artery bypass surgery determined the development of a technology for delivering nitric oxide (NO) to the systemic blood flow using a cardiopulmonary bypass (CB) apparatus,…
View article: Relationship between mitochondrial respiratory dysfunction of blood mononuclear cells and heart failure severity
Relationship between mitochondrial respiratory dysfunction of blood mononuclear cells and heart failure severity Open
Chronic heart failure (CHF) is a clinical syndrome manifested by reduced pumping ability of the heart, increased pressure in heart chambers in both physical activity and at rest.The symptoms of this syndrome are dyspnea, undue fatigability…
View article: Prognostic value of combined assessment of cardiac autonomic system activity in appropriate cardioverter-defibrillator therapy prediction
Prognostic value of combined assessment of cardiac autonomic system activity in appropriate cardioverter-defibrillator therapy prediction Open
Objective. This prospective study aimed to determine the prognostic value of the combined assessment of cardiac autonomic nervous system (CANS) activity in appropriate implanted cardioverter-defibrillator (ICD) therapy predicting in patien…
View article: Five-year dynamics adrenergic reactivity of erythrocytes after radio-frequency sympathic denervation of renal arteries in patients with resistant arterial hypertension
Five-year dynamics adrenergic reactivity of erythrocytes after radio-frequency sympathic denervation of renal arteries in patients with resistant arterial hypertension Open
Aim. To study the initial state of adrenergic reactivity and the five-year dynamics of the beta-adrenergic reactivity index of erythrocyte membranes and the manifestation of the antihypertensive effect of the procedure for radiofrequency d…
View article: Βeta-adrenergic receptor reactivity of erythrocyte membranes in patients with left or right atrial dilatation against the background of atrial fibrillation
Βeta-adrenergic receptor reactivity of erythrocyte membranes in patients with left or right atrial dilatation against the background of atrial fibrillation Open
Hyperactivation of the sympathoadrenal system (SAS) leads to desensitization of β1-adrenergic receptors (β1-AR). This contributes to aggravation of myocardial contractile dysfunction and development of arrhythmias, including atrial fibrill…
View article: Beta-adrenoreactivity of erythrocyte membranes and expression of beta1-adrenergic receptors of cardiomyocytes in patients with heart failure with different left ventricular ejection fraction
Beta-adrenoreactivity of erythrocyte membranes and expression of beta1-adrenergic receptors of cardiomyocytes in patients with heart failure with different left ventricular ejection fraction Open
Introduction. More and more studies demonstrate the importance of determining the beta-adrenergic reactivity of erythrocyte membranes (beta-ARM) for predicting the severity of cardiovascular diseases, including chronic heart failure. But t…
View article: The effect of the autonomic nervous system on the formation of cardiac arrhythmias in childhood (review)
The effect of the autonomic nervous system on the formation of cardiac arrhythmias in childhood (review) Open
Heart rhythm disorders (HRDs) are one of the most complex and urgent problems in both adult and pediatric cardiology. One of the important points of research in the field of arrhythmology is the study of the mechanisms of HRD formation. Th…
View article: Mitochondrial DNA Mutations in Cardiovascular Diseases
Mitochondrial DNA Mutations in Cardiovascular Diseases Open
Early prevention of development and timely diagnosis of diseases of the cardiovascular system are some of the main tasks of modern cardiology. One of the promising approaches is aimed at identifying associations between the carriage of mit…
View article: Respiration in isolated cardiomyocytes and microviscosity of their membranes in rats of different ages with heart failure
Respiration in isolated cardiomyocytes and microviscosity of their membranes in rats of different ages with heart failure Open
Background. According to the latest epidemiological data, heart failure (HF) is diagnosed in 10% of adult population over 70 years old. However, currently this diagnosis is being increasingly made in young and middleaged people. The pathog…
View article: Myocardial inotropic response of rats of different ages to extrasystolic exposures in postinfarction cardiosclerosis
Myocardial inotropic response of rats of different ages to extrasystolic exposures in postinfarction cardiosclerosis Open
The age-dependent features of the inotropic response of isolated strips of rat papillary muscles in postinfarction cardiosclerosis were studied. The rhythmic-inotropic response of the myocardium to extrasystolic effects was assessed in sha…
View article: Cardiomyocyte mitochondrial respiration and microviscosity in rats of different ages in heart failure
Cardiomyocyte mitochondrial respiration and microviscosity in rats of different ages in heart failure Open
Highlights . Heart failure in older age groups is an urgent medical and social issue. Mitochondrial dysfunction is a key link in the pathogenesis of heart failure. In this study we have demonstrated a decrease in mitochondrial respiratory …
View article: Features of erythrocyte membranes beta-adrenoreactivity in patients with resistant hypertension and type 2 diabetes mellitus
Features of erythrocyte membranes beta-adrenoreactivity in patients with resistant hypertension and type 2 diabetes mellitus Open
Introduction . Patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (T2DM) are characterized by sympathetic hyperactivity. A promising method for the assessment is a measurement of erythrocyte membrane beta-adrenergic r…
View article: Association between the osmotic fragility of erythrocytes and the course of acute myocardial infarction
Association between the osmotic fragility of erythrocytes and the course of acute myocardial infarction Open
Aim . To investigate the relationship between the osmotic fragility of erythrocytes and the course of acute myocardial infarction (MI). Methods . An analysis of the osmotic fragility of erythrocytes was conducted using beta-blocker-based o…
View article: Erythrocyte membranes beta-adrenoreactivity changes after renal denervation in patients with resistant hypertension, relationship with antihypertensive and cardioprotective intervention efficacy
Erythrocyte membranes beta-adrenoreactivity changes after renal denervation in patients with resistant hypertension, relationship with antihypertensive and cardioprotective intervention efficacy Open
Aim To study the functional condition of sympathoadrenal system as evaluated by beta-adrenoreactivity of erythrocyte membranes (beta-ARM) during two years following renal denervation (RD) in patients with resistant arterial hypertension (R…