Tatjana Ruskovska
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View article: Impact of (poly)phenol-rich dietary sources on DNA damage: insights from human intervention studies using the Comet assay – a review and perspective
Impact of (poly)phenol-rich dietary sources on DNA damage: insights from human intervention studies using the Comet assay – a review and perspective Open
(Poly)phenols are plant-derived food bioactives abundantly present in human diet. They exert positive effects on various aspects of human health and in particular in reducing the risk of chronic non-communicable diseases. Dietary (poly)phe…
View article: Current Situation and Management of Pleural Effusion in PHI Clinical Hospital Tetovo
Current Situation and Management of Pleural Effusion in PHI Clinical Hospital Tetovo Open
Introduction: Pleural effusion is a disturbance in the balance between fluid production and elimination in the pleural space, resulting in abnormal fluid accumulation. It can result from various medical conditions related to the lungs and …
View article: Label-free voltammetric screening of human blood serum
Label-free voltammetric screening of human blood serum Open
The current study presents a comprehensive voltammetric investigation into the direct analysis of untreated human blood serum in a phosphate buffer at an unmodified, graphite electrode by means of voltammetry. By employing advanced square-…
View article: Integrated Analysis of Genomic and Genome-Wide Association Studies Identified Candidate Genes for Nutrigenetic Studies in Flavonoids and Vascular Health: Path to Precision Nutrition for (Poly)phenols
Integrated Analysis of Genomic and Genome-Wide Association Studies Identified Candidate Genes for Nutrigenetic Studies in Flavonoids and Vascular Health: Path to Precision Nutrition for (Poly)phenols Open
Flavonoids exert vasculoprotective effects in humans, but interindividual variability in their action has also been reported. This study aims to identify genes that are associated with vascular health effects of flavonoids and whose polymo…
View article: Exploring the Relationship between Mediterranean Diet Adherence and Subjective Well-Being among Greek and Cypriot Adults
Exploring the Relationship between Mediterranean Diet Adherence and Subjective Well-Being among Greek and Cypriot Adults Open
Associations between subjective well-being (SWB) and dietary habits, employment status, and habitual activities are increasingly capturing the focus of researchers as well as policymakers worldwide. This study aimed to explore these associ…
View article: Integrated Analysis of Genomic and GWAS Data to Identify Candidate Genes for Genetic Studies in Flavonoids and Vascular Health: Path to Precise Nutrition for (Poly)phenols
Integrated Analysis of Genomic and GWAS Data to Identify Candidate Genes for Genetic Studies in Flavonoids and Vascular Health: Path to Precise Nutrition for (Poly)phenols Open
Good vascular function is one of the key determinants of a healthy heart and preserved neurofunction in advanced age. Previous studies demonstrated vasculoprotective effects of flavonoids, but also inter-individual variability in their act…
View article: The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance Open
Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin …
View article: Square-wave voltammetry of human blood serum
Square-wave voltammetry of human blood serum Open
View article: Square-Wave Voltammetry of Human Blood Serum
Square-Wave Voltammetry of Human Blood Serum Open
A study on voltammetric analysis of whole blood serum is presented using advanced square-wave voltammetry at an edge plane pyrolytic graphite electrode. The results demonstrate that even in a complex medium like human blood serum, electroc…
View article: Editorial: Plant food bioactives, genomics, and health effects
Editorial: Plant food bioactives, genomics, and health effects Open
EDITORIAL article Front. Nutr., 08 March 2023Sec. Nutrigenomics Volume 10 - 2023 | https://doi.org/10.3389/fnut.2023.1166149
View article: BJN volume 129 issue 2 Cover and Back matter
BJN volume 129 issue 2 Cover and Back matter Open
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View article: Exploring Hedonic and Eudaimonic Items of Well-Being in Mediterranean and Non-Mediterranean Countries: Influence of Sociodemographic and Lifestyle Factors
Exploring Hedonic and Eudaimonic Items of Well-Being in Mediterranean and Non-Mediterranean Countries: Influence of Sociodemographic and Lifestyle Factors Open
Increased understanding of subjective well-being (SWB), as well as factors that influence it, are essential to enhance well-being at the individual and national level. We have applied a hedonic and eudaimonic 9-item composed tool (SWB scor…
View article: Circadian rhythm and time-of-day-effects of (anti)oxidant biomarkers for epidemiological studies
Circadian rhythm and time-of-day-effects of (anti)oxidant biomarkers for epidemiological studies Open
Various biomarkers of oxidative stress and redox status have been used in a number of clinical and epidemiological studies related to diseases and conditions that involve disturbances of the redox balance. However, a comprehensive study of…
View article: Vitamins E and C exert protective roles in hydrogen peroxide-induced DNA damage in human peripheral blood mononuclear cells
Vitamins E and C exert protective roles in hydrogen peroxide-induced DNA damage in human peripheral blood mononuclear cells Open
Hydrogen peroxide (H2O2) exerts strong oxidative, cytotoxic, and genotoxic effects, whereas vitamins C and E are potent non-enzymatic antioxidants. This study aimed to demonstrate the ameliorative effects of vitamins C and E, individually …
View article: Clinical significance of circulating enzymes in patients with COVID-19
Clinical significance of circulating enzymes in patients with COVID-19 Open
Laboratory tests in patients with COVID-19 are of particular importance to assure correct approach towards the patient, both at the time of diagnosis and further during the treatment. The goal of this study was to conduct detailed analysis…
View article: Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies
Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies Open
Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Ai…
View article: Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies
Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies Open
Scope: Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underly…
View article: Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations?
Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations? Open
The Mediterranean diet (MD) has been sponsored worldwide as a healthy and sustainable diet. Our aim was to update and compare MD adherence and food choices across several Southern European countries: Spain (SP), Portugal (PT), Italy (IT), …
View article: Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells
Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells Open
Coronaviruses (CoVs) are single-stranded RNA viruses which following virus attachment and entry into the host cell, particularly type 2 pneumocytes but also endothelial cells, release RNA into cytosol where it serves as a matrix for the ho…
View article: Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults
Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults Open
The Mediterranean diet (MD) and other lifestyle characteristics have been associated with well-being, a broad multiparameter concept that includes individual’s subjective assessment of their own well-being (SWB). Some studies have suggeste…
View article: Critical points in Comet assay silver staining procedure
Critical points in Comet assay silver staining procedure Open
Comet assay is one of the most common methods for measuring DNA damage in eukaryotic cells. In 1984, Ostling and Johanson demonstrated movement of DNA strands when nuclei were exposed to an electric field. Later, Singh et al. (1998) modifi…
View article: Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region
Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region Open
This study provides comprehensive validation of the 14-item Mediterranean Diet Adherence Screener (14-MEDAS) in an adult population from Greece (GR), Portugal (PT), Italy (IT), Spain (SP), Cyprus (CY), Republic of North Macedonia (NMK), an…
View article: Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease
Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease Open
Flavanol intake positively influences cardiometabolic health in humans – evidence fromin vitronutrigenomic studies.
View article: Polyphenols in human nutrition: from the<i>in vitro</i>antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability – an overview and perspective
Polyphenols in human nutrition: from the<i>in vitro</i>antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability – an overview and perspective Open
Oxidative damage of cells and tissues is broadly implicated in human pathophysiology, including cardiometabolic diseases. Polyphenols, as important constituents of the human diet and potent in vitro free radical scavengers, have been exten…
View article: PREPARATION AND INTEGRITY EXAMINATION OF FREEZE DRIED KIT OF TRASTUZUMAB-IMMUNOCONJUGATES AND COLD LABELED IMMUNOCONJUGATES BY APPLYING SDS-PAGE ELECTROPHORESIS
PREPARATION AND INTEGRITY EXAMINATION OF FREEZE DRIED KIT OF TRASTUZUMAB-IMMUNOCONJUGATES AND COLD LABELED IMMUNOCONJUGATES BY APPLYING SDS-PAGE ELECTROPHORESIS Open
Radioimmunoconjugates are promising agents in diagnostic and treatment of different types of cancers. The aim of this study is formulation of stable freeze dried kits of trastuzumab with three types of bifunctional chelators for further ra…
View article: Factors influencing the cardiometabolic response to (poly)phenols and phytosterols: a review of the COST Action POSITIVe activities
Factors influencing the cardiometabolic response to (poly)phenols and phytosterols: a review of the COST Action POSITIVe activities Open
Understanding why some bioactive plant compounds work effectively in some individuals but not, or less, in others is crucial for a full consideration of these compounds in future strategies of personalized nutrition for a better prevention…
View article: Analysis of nutrigenomic effects of flavanols: a systematic bioinformatic evaluation of flavanol-modulated gene expressions in cell models of cardiometabolic disease
Analysis of nutrigenomic effects of flavanols: a systematic bioinformatic evaluation of flavanol-modulated gene expressions in cell models of cardiometabolic disease Open
Resumen del trabajo presentado al 13th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN), celebrado en Cambridge (UK) del 12 al 13 de julio de 2019.
View article: Impact of Flavonols on Cardiometabolic Biomarkers: A Meta‐Analysis of Randomized Controlled Human Trials to Explore the Role of Inter‐Individual Variability
Impact of Flavonols on Cardiometabolic Biomarkers: A Meta‐Analysis of Randomized Controlled Human Trials to Explore the Role of Inter‐Individual Variability Open
Several epidemiological studies have linked flavonols with decreased risk of cardiovascular disease (CVD). However, some heterogeneity in the individual physiological responses to the consumption of these compounds has been identified. Thi…
View article: Cigarette Smoking and Oxidative Stress in Patients with Coronary Artery Disease
Cigarette Smoking and Oxidative Stress in Patients with Coronary Artery Disease Open
AIM: To determine whether cigarette smoking, as a risk factor for CAD, affects oxidative stress.MATERIAL AND METHODS: The study included patients with CAD divided according to smoking status and number of cigarettes smoked during a whole d…
View article: Metabolic disturbances in obesity
Metabolic disturbances in obesity Open
Background: Sedentary lifestyle and readily availability of calorie dense foods lead to overweight and obesity, which are considered major health concerns of the modern world. Overweight and obese subjects are at high risk of cardiovascula…