Tatsushi Yokoyama
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View article: Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance
Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance Open
View article: Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation
Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation Open
Opioid receptors (ORs) are critical for endogenous and synthetic analgesics. OR homodimerization is considered important for their pharmacological diversity, but whether they form homodimers remains controversial. Here, we establish that t…
View article: The astrocytic ensemble acts as a multiday trace to stabilize memory
The astrocytic ensemble acts as a multiday trace to stabilize memory Open
Recalled memories become transiently labile and require stabilization 1–3 . The mechanism for stabilizing memories of survival-critical experiences, which are often emotionally salient and repeated, remains unclear 4 . Here we identify an …
View article: Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP <sub>3</sub> R2-mediated Ca <sup>2+</sup> signaling in mice
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP <sub>3</sub> R2-mediated Ca <sup>2+</sup> signaling in mice Open
Local neural activation drives regional increase of cerebral blood flow (CBF), in a phenomenon known as functional hyperemia. Astrocytes, which enwrap cerebral blood vessels and respond to neuronal activity through their G protein–coupled …
View article: Neuropeptidergic Input from the Lateral Hypothalamus to the Suprachiasmatic Nucleus Alters the Circadian Period in Mice
Neuropeptidergic Input from the Lateral Hypothalamus to the Suprachiasmatic Nucleus Alters the Circadian Period in Mice Open
In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which transmits circadian information to other brain regions and regulates the timing of sleep and wakefulness. Neurons in the lat…
View article: Probing neuronal activity with genetically encoded calcium and voltage fluorescent indicators
Probing neuronal activity with genetically encoded calcium and voltage fluorescent indicators Open
View article: A multicolor suite for deciphering population coding of calcium and cAMP in vivo
A multicolor suite for deciphering population coding of calcium and cAMP in vivo Open
cAMP is a universal second messenger regulated by various upstream pathways including Ca 2+ and G-protein-coupled receptors (GPCRs). To decipher in vivo cAMP dynamics, we rationally designed cAMPinG1, a sensitive genetically encoded green …
View article: Genome-wide CRISPR screen identifies AC9 as a key regulator of ER Ca<sup>2+</sup>homeostasis involved in neuronal differentiation
Genome-wide CRISPR screen identifies AC9 as a key regulator of ER Ca<sup>2+</sup>homeostasis involved in neuronal differentiation Open
Endoplasmic reticulum (ER) calcium (Ca 2+ ) homeostasis is essential for maintaining normal cellular physiological functions. Its disturbance is strongly linked to the onset and progression of human diseases, including cancer, developmenta…
View article: A multicolor suite for deciphering population coding in calcium and cAMP<i>in vivo</i>
A multicolor suite for deciphering population coding in calcium and cAMP<i>in vivo</i> Open
SUMMARY cAMP is a pivotal second messenger regulated by various upstream pathways including Ca 2+ and G protein-coupled receptors (GPCRs). To decipher in vivo cAMP dynamics, we rationally designed cAMPinG1, an ultrasensitive genetically en…
View article: A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo
A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo Open
View article: Imaging Voltage with Microbial Rhodopsins
Imaging Voltage with Microbial Rhodopsins Open
Membrane potential is the critical parameter that reflects the excitability of a neuron, and it is usually measured by electrophysiological recordings with electrodes. However, this is an invasive approach that is constrained by the proble…
View article: A Photodeactivatable Antagonist for Controlling CREB-Dependent Gene Expression
A Photodeactivatable Antagonist for Controlling CREB-Dependent Gene Expression Open
A novel photodeactivation strategy for controlling gene expression has been developed based on light-induced activation of cAMP response element binding protein (CREB). Light-induced cleavage of the photoresponsive protecting group of an a…
View article: Deciphering Ca2+-dopendent signaling pathways underlying cognitive processes
Deciphering Ca2+-dopendent signaling pathways underlying cognitive processes Open
View article: A case of recurrent depressive disorder presenting with Alice in Wonderland syndrome: psychopathology and pre- and post-treatment FDG-PET findings
A case of recurrent depressive disorder presenting with Alice in Wonderland syndrome: psychopathology and pre- and post-treatment FDG-PET findings Open