Tatsuya Atsumi
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View article: Mobile Continuous Kidney Replacement Therapy for Appropriate Radioactive Iodine Administration in a Hemodialysis Patient: A Case Report
Mobile Continuous Kidney Replacement Therapy for Appropriate Radioactive Iodine Administration in a Hemodialysis Patient: A Case Report Open
Background: Radioactive iodine (RAI) therapy is an important adjuvant treatment for differentiated thyroid cancer following thyroidectomy. In patients with end stage kidney disease (ESKD), including those on hemodialysis, the reduced renal…
View article: Factors related to seroconversion of anti-cyclic citrullinated peptide antibody after the onset of rheumatoid arthritis: a case-control study and systematic review
Factors related to seroconversion of anti-cyclic citrullinated peptide antibody after the onset of rheumatoid arthritis: a case-control study and systematic review Open
Anti-cyclic citrullinated peptide (CCP) antibodies typically present before rheumatoid arthritis (RA) but appear (seroconvert) after disease onset in some patients. This study analyzed factors related to anti-CCP seroconversion. Fifty-six …
View article: Efficacy and safety of tirzepatide in subjects with type 2 diabetes and chronic kidney disease: a prospective, two-arm observational study
Efficacy and safety of tirzepatide in subjects with type 2 diabetes and chronic kidney disease: a prospective, two-arm observational study Open
Background: Tirzepatide (TZP) has demonstrated efficacy for glycemic control and weight loss in subjects with type 2 diabetes (T2D). However, previous clinical trials were not conducted under the treatment of glucagon-like peptide-1 recept…
View article: Unmet needs and emerging pharmacotherapies for autoimmune connective tissue disease-associated interstitial lung diseases
Unmet needs and emerging pharmacotherapies for autoimmune connective tissue disease-associated interstitial lung diseases Open
Autoimmune connective tissue disease associated with interstitial lung disease (CTD-ILD) includes rheumatoid arthritis-associated ILD, systemic sclerosis-associated-ILD, and several other ILDs. Many patients with CTD-ILD-as well as individ…
View article: A preliminary report on the feasibility of regression-based alignment of diagnostic thresholds for harmonized use of international classification criteria for antiphospholipid syndrome
A preliminary report on the feasibility of regression-based alignment of diagnostic thresholds for harmonized use of international classification criteria for antiphospholipid syndrome Open
Background In 2023, international rheumatology societies issued new classification criteria for antiphospholipid syndrome (APS). The criteria require scoring antiphospholipid antibody (aPL) titers as moderate or high using the traditional …
View article: Development and validation of a simplified CT volumetry for estimating total liver volume in patients with autosomal dominant polycystic kidney and liver disease
Development and validation of a simplified CT volumetry for estimating total liver volume in patients with autosomal dominant polycystic kidney and liver disease Open
Background Accurate liver volume measurement is crucial for evaluating liver cyst severity and treatment efficacy in polycystic liver disease (PLD). Previous methods are impractical because they are time-consuming and labor-intensive. This…
View article: Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells
Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells Open
Introduction Pancreatic beta cells undergo metabolic remodeling in response to metabolic overload, but the functional significance of this remains unclear. 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is a glycolytic regu…
View article: Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement
Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement Open
In patients with GPA or MPA with kidney involvement, treatment with an avacopan regimen compared with a prednisone taper regimen achieved similar rates of remission, improved recovery of kidney function, led to faster reduction in albuminu…
View article: OP0169 TOCILIZUMAB VERSUS CYCLOPHOSPHAMIDE FOR MICROSCOPIC POLYANGIITIS AND GRANULOMATOSIS WITH POLYANGIITIS
OP0169 TOCILIZUMAB VERSUS CYCLOPHOSPHAMIDE FOR MICROSCOPIC POLYANGIITIS AND GRANULOMATOSIS WITH POLYANGIITIS Open
View article: Impact of preoperative NAFLD status on restoration of pancreatic β-cell function after laparoscopic sleeve gastrectomy
Impact of preoperative NAFLD status on restoration of pancreatic β-cell function after laparoscopic sleeve gastrectomy Open
In the present study, pancreatic beta-cell function improved at 1 year postoperatively in subjects with obesity and type 2 diabetes (T2D) who underwent laparoscopic sleeve gastrectomy. Preoperative liver fibrosis and steatosis were associa…
View article: Subacute Finger Gangrene with Severe Raynaud's Phenomenon
Subacute Finger Gangrene with Severe Raynaud's Phenomenon Open
View article: Three-year safety and effectiveness of tofacitinib in patients with rheumatoid arthritis in Japan: Final analysis of an all-case postmarketing surveillance study
Three-year safety and effectiveness of tofacitinib in patients with rheumatoid arthritis in Japan: Final analysis of an all-case postmarketing surveillance study Open
Objective To evaluate tofacitinib real-world safety/effectiveness in patients with rheumatoid arthritis (RA) in Japan in a 3-year all-case postmarketing surveillance study. Methods All patients with RA who initiated tofacitinib (30 July 20…
View article: Long-term safety and efficacy of anti-GM-CSF otilimab in patients with rheumatoid arthritis: long-term extension of three phase 3 randomised trials (contRAst X)
Long-term safety and efficacy of anti-GM-CSF otilimab in patients with rheumatoid arthritis: long-term extension of three phase 3 randomised trials (contRAst X) Open
Objectives To investigate the long-term safety and efficacy of otilimab, an antigranulocyte-macrophage colony-stimulating factor monoclonal antibody, for patients with rheumatoid arthritis (RA). Methods ContRAst X ( NCT04333147 ) was a pha…
View article: Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints
Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints Open
Objective To study the classification performance of a pre-trained convolutional neural network (CNN) with transfer learning by artificial joint ultrasonography images in rheumatoid arthritis (RA). Methods This retrospective study focused …
View article: Performance of the modified 2022 ACR/EULAR giant cell arteritis classification criteria without age restriction for discriminating from Takayasu arteritis
Performance of the modified 2022 ACR/EULAR giant cell arteritis classification criteria without age restriction for discriminating from Takayasu arteritis Open
View article: Efficacy of anifrolumab in systemic lupus erythematosus patients with serological manifestations: A post hoc analysis of the Japan subgroup of the TULIP-2 trial
Efficacy of anifrolumab in systemic lupus erythematosus patients with serological manifestations: A post hoc analysis of the Japan subgroup of the TULIP-2 trial Open
Objectives To describe the efficacy of anifrolumab versus placebo in Japanese systemic lupus erythematosus (SLE) patients with low complement (C3 or C4) and/or who are positive for anti-double stranded DNA antibodies. Methods This was a de…
View article: FACTORS COMPLICATING CONSENSUS BUILDING AND THE TRANSITION OF THE CONSULTATION PROCESS —A QUESTIONNAIRE SURVEY TO THE PROJECT IMPLEMENTERS—
FACTORS COMPLICATING CONSENSUS BUILDING AND THE TRANSITION OF THE CONSULTATION PROCESS —A QUESTIONNAIRE SURVEY TO THE PROJECT IMPLEMENTERS— Open
View article: The Uncoupling of Disease Activity from Joint Structural Progression in Patients with Rheumatoid Arthritis Treated with Filgotinib
The Uncoupling of Disease Activity from Joint Structural Progression in Patients with Rheumatoid Arthritis Treated with Filgotinib Open
View article: Safety and efficacy of filgotinib in Japanese patients with rheumatoid arthritis: Week 156 interim results in FINCH 4
Safety and efficacy of filgotinib in Japanese patients with rheumatoid arthritis: Week 156 interim results in FINCH 4 Open
Objectives The aim of this article is to describe the safety and efficacy of filgotinib 200 mg (FIL200) or FIL 100 mg (FIL100) in Japanese patients with rheumatoid arthritis in a long-term extension (NCT03025308). Methods Patients who comp…
View article: Effects of canagliflozin on brain natriuretic peptide levels in patients with type 2 diabetes on peritoneal dialysis in Japan: protocol for a multicentre, prospective, randomised controlled trial (CARD-PD trial)
Effects of canagliflozin on brain natriuretic peptide levels in patients with type 2 diabetes on peritoneal dialysis in Japan: protocol for a multicentre, prospective, randomised controlled trial (CARD-PD trial) Open
Introduction Patients with type 2 diabetes (T2D) undergoing dialysis exhibit a higher mortality rate compared with those with other conditions, primarily due to vascular complications including coronary artery disease, heart failure and st…
View article: ANA-positive <i>versus</i> ANA-negative Antiphospholipid Antibody-positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Clinical Database and Repository (“Registry”)
ANA-positive <i>versus</i> ANA-negative Antiphospholipid Antibody-positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Clinical Database and Repository (“Registry”) Open
Objectives This study focused on the prevalence and impact of ANA in aPL-positive patients without concomitant systemic autoimmune rheumatic diseases (SARDs). Methods Data from aPL-positive patients with or without Revised Sapporo APS clas…
View article: Comparison of different ANCA detection methods in a predominantly MPO-ANCA-associated vasculitis cohort
Comparison of different ANCA detection methods in a predominantly MPO-ANCA-associated vasculitis cohort Open
We compared different antineutrophil cytoplasmic antibody (ANCA) detection methods using a predominantly myeloperoxidase (MPO)-ANCA-associated vasculitis cohort. Stored sera from 147 patients with untreated ANCA-associated vasculitis (AAV)…
View article: 6571 Tracking Emotional Well-being And Hormonal Interactions In Adrenal Insufficiency Through Ecological Momentary Assessment
6571 Tracking Emotional Well-being And Hormonal Interactions In Adrenal Insufficiency Through Ecological Momentary Assessment Open
Disclosure: A. Miya: None. A. Suga: None. Y. Suzuki: None. H. Nomoto: None. H. Kameda: None. A. Nakamura: None. H. Ohira: None. T. Nakamura: None. Y. Ozaki: None. T. Atsumi: None. Background: For people undergoing glucocorticoid replacemen…
View article: 6376 Wnt/beta-catenin Pathway is Associated with Cell Proliferation in Growth Hormone-producing Pituitary Tumors
6376 Wnt/beta-catenin Pathway is Associated with Cell Proliferation in Growth Hormone-producing Pituitary Tumors Open
Disclosure: S. Kuwabara: None. H. Kameda: None. H. Nomoto: None. K. Cho: None. A. Nakamura: None. Y. Ishi: None. H. Motegi: None. M. Fujimura: None. T. Atsumi: None. Objective: It has been well recognized that the Wnt/β-catenin pathway reg…
View article: 6372 Changes in Blood Steroid Hormone Profile after Switching from Metyrapone to Osilodrostat
6372 Changes in Blood Steroid Hormone Profile after Switching from Metyrapone to Osilodrostat Open
Disclosure: K. Yokozeki: None. H. Kameda: None. A. Miya: None. H. Nomoto: None. A. Nakamura: None. S. Jin: None. K. Matoba: None. T. Atsumi: None. Background: The new steroidogenesis inhibitor osilodrostat has recently been approved for us…
View article: Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice
Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice Open
Aims/Introduction We previously showed that glucokinase haploinsufficiency improves the glucose tolerance of db/db mice by preserving pancreatic β‐cell mass and function. In the present study, we aimed to determine the effects of glucokina…
View article: Clinical Characteristics and Treatment Outcomes of Patients With Newly Diagnosed Takayasu Arteritis in Japan During the First 2 Years of Treatment ― A Nationwide Retrospective Cohort Study ―
Clinical Characteristics and Treatment Outcomes of Patients With Newly Diagnosed Takayasu Arteritis in Japan During the First 2 Years of Treatment ― A Nationwide Retrospective Cohort Study ― Open
We elucidated the clinical characteristics, treatment outcomes, and factors associated with failure to achieve sustained clinical remission in patients with newly diagnosed TAK in Japan during the first 2 years of treatment.
View article: Introduction
Introduction Open
View article: Safety, pharmacokinetics, biomarker response and efficacy of E6742: a dual antagonist of Toll-like receptors 7 and 8, in a first in patient, randomised, double-blind, phase I/II study in systemic lupus erythematosus
Safety, pharmacokinetics, biomarker response and efficacy of E6742: a dual antagonist of Toll-like receptors 7 and 8, in a first in patient, randomised, double-blind, phase I/II study in systemic lupus erythematosus Open
Objectives To evaluate the safety, tolerability, pharmacokinetics (PK), biomarker response and efficacy of E6742 in a phase I/II study in patients with systemic lupus erythematosus (SLE). Methods Two sequential cohorts of patients with SLE…
View article: Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints
Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints Open
Objectives To study the classification performance of a pre-trained convolutional neural network (CNN) with transfer learning by artificial images of the joint ultrasonography in rheumatoid arthritis (RA). Methods We focused on abnormal sy…