Tavis J. Reed
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View article: Exploring How Workflow Variations in Denaturation-Based Assays Impact Global Protein-Protein Interaction Predictions
Exploring How Workflow Variations in Denaturation-Based Assays Impact Global Protein-Protein Interaction Predictions Open
Protein denaturation-based assays, such as thermal proximity coaggregation (TPCA) and ion-based proteome-integrated solubility alteration (I-PISA), are powerful tools for characterizing global protein-protein interaction (PPI) networks. Th…
View article: Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3
Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3 Open
Aldehyde dehydrogenase 1a3 (ALDH1A3) activity is recognized as a pathogenic trait in cardiometabolic diseases and cancer, though the mechanisms by which ALDH1A3 promotes disease are unclear and effective therapeutic inhibitors of ALDH1A3 a…
View article: Sequestration of ribosome biogenesis factors in HSV-1 nuclear aggregates revealed by spatially resolved thermal profiling
Sequestration of ribosome biogenesis factors in HSV-1 nuclear aggregates revealed by spatially resolved thermal profiling Open
Viruses exploit host cell reliance on compartmentalization to facilitate their replication. Herpes simplex virus type 1 (HSV-1) modulates the subcellular localization of host proteins to suppress immune activation, license viral gene expre…
View article: Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures
Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures Open
Huntington’s disease (HD) is a debilitating neurodegenerative disorder affecting an individual’s cognitive and motor abilities. HD is caused by mutation in the huntingtin gene producing a toxic polyglutamine-expanded protein (mHTT) and lea…