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View article: High-throughput expansion microscopy enables scalable super-resolution imaging
High-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: Single-shot 20-fold expansion microscopy
Single-shot 20-fold expansion microscopy Open
Expansion microscopy (ExM) is in increasingly widespread use throughout biology because its isotropic physical magnification enables nanoimaging on conventional microscopes. To date, ExM methods either expand specimens to a limited range (…
View article: HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: Reviewer #3 (Public Review): HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
Reviewer #3 (Public Review): HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: High-throughput expansion microscopy enables scalable super-resolution imaging
High-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: Author response: HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
Author response: HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: Reviewer #1 (Public Review): HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
Reviewer #1 (Public Review): HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: Reviewer #2 (Public Review): HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
Reviewer #2 (Public Review): HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: Dense, Continuous Membrane Labeling and Expansion Microscopy Visualization of Ultrastructure in Tissues
Dense, Continuous Membrane Labeling and Expansion Microscopy Visualization of Ultrastructure in Tissues Open
Lipid membranes are key to the nanoscale compartmentalization of biological systems, but fluorescent visualization of them in intact tissues, with nanoscale precision, is challenging to do with high labeling density. Here, we report ultras…
View article: A marmoset brain cell census reveals regional specialization of cellular identities
A marmoset brain cell census reveals regional specialization of cellular identities Open
The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 million brain cells across 18 locations in the common marmoset, a N…
View article: Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs
Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs Open
Expansion microscopy (ExM), by physically enlarging specimens in an isotropic fashion, enables nanoimaging on standard light microscopes. Key to existing ExM protocols is the equipping of different kinds of molecules, with different kinds …
View article: Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation
Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation Open
Heparan sulfate (HS) is a heterogeneous, cell-surface polysaccharide critical for transducing signals essential for mammalian development. Imaging of signaling proteins has revealed how their localization influences their information trans…
View article: HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging Open
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membra…
View article: A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity
A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity Open
The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. Transcriptionally-based cell type taxonomies reveal cell type composition and similarity relationships within and across bra…
View article: Expansion Microscopy of Lipid Membranes
Expansion Microscopy of Lipid Membranes Open
Lipids are fundamental building blocks of cells and their organelles, yet nanoscale resolution imaging of lipids has been largely limited to electron microscopy techniques. We introduce and validate a chemical tag that enables lipid membra…