Taylor Borrill
YOU?
Author Swipe
View article: Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin
Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin Open
Quality of immune reconstitution after cord blood transplantation (CBT) without antithymocyte globulin (ATG) in adults is not established. We analyzed immune recovery in 106 engrafted adult CBT recipients (median age 50 years [range 22-70]…
View article: Cytomegalovirus Reactivation Promotes CD8+ T Cell Subset Recovery after Unmodified Allogeneic Hematopoietic Cell Transplantation
Cytomegalovirus Reactivation Promotes CD8+ T Cell Subset Recovery after Unmodified Allogeneic Hematopoietic Cell Transplantation Open
IntroductionT cell reconstitution after alloHCT can be impaired and is associated with relapse as well as infections, especially viral reactivation. Our study is aimed at characterizing patterns of T cell subset recovery in patients underg…
View article: Rituximab Use, Immune Reconstitution, and Vaccination after Ex-Vivo CD34-Selected Myeloablative Allogeneic Hematopoietic Cell Transplantation (HCT)
Rituximab Use, Immune Reconstitution, and Vaccination after Ex-Vivo CD34-Selected Myeloablative Allogeneic Hematopoietic Cell Transplantation (HCT) Open
Background: Myeloablative T-cell depleted (CD34-selected) HCT is associated with less acute and chronic GvHD and comparable survival compared to unmodified grafts. Since, delayed T-cell recovery can impact the ability to re-vaccinate, we e…
View article: Early CMV Reactivation Adversely Impacts Blood Counts Recovery at 1 Year Post-Transplant in Recipients of CD34+ Selected Graft
Early CMV Reactivation Adversely Impacts Blood Counts Recovery at 1 Year Post-Transplant in Recipients of CD34+ Selected Graft Open
Background: We recently reported that early CMV reactivation has adverse impact on blood counts recovery post CD34+ selected allogeneic hematopoietic stem cell transplantation (allo-HCT) (ASH 2017 poster 3319). Aim: To study the effects of…
View article: Comparison of T Cell Subset Recovery after Cord Blood and CD34-Selected Pbsc Transplantation
Comparison of T Cell Subset Recovery after Cord Blood and CD34-Selected Pbsc Transplantation Open
Background: Both T cell depletion (TCD) by CD34 selection and cord blood transplantation (CBT) play important roles in allogeneic HCT practice. Both, however, have traditionally been associated with impaired immune reconstitution and highe…
View article: Disease Progression is Main Barrier to Allogeneic Hematopoietic Stem Cell Transplantation (HCT) in Patients with Newly Diagnosed and Relapsed Acute Leukemia
Disease Progression is Main Barrier to Allogeneic Hematopoietic Stem Cell Transplantation (HCT) in Patients with Newly Diagnosed and Relapsed Acute Leukemia Open
Background: Multiple studies demonstrated the curative effect of HCT for patients (pts) with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), but it is estimated that only 1 of 3 eligible pts undergo this procedure. His…
View article: Impact of Toxicity on Survival for Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation
Impact of Toxicity on Survival for Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation Open
Ex vivo CD34+ selection before allogeneic hematopoietic stem cell transplantation (allo-HCT) reduces graft-versus-host disease without increasing relapse but usually requires myeloablative conditioning. We aimed to identify toxicity patter…
View article: CMV Seropositivity and Viremia Drive T-Cell Reconstitution after CD34-Selected Allogeneic HCT
CMV Seropositivity and Viremia Drive T-Cell Reconstitution after CD34-Selected Allogeneic HCT Open
Introduction: T-cell depleted (TCD) allogeneic HCT using CD34 selection is associated with delayed T-cell recovery and risk of infectious complications. We sought to better characterize T-cell recovery after TCD and assess its relationship…
View article: Post-Transplant Toxicities and Outcomes in Long-Term Survivors of Ex-Vivo CD34+ Selected Allogeneic Hematopoietic Cell Transplantation
Post-Transplant Toxicities and Outcomes in Long-Term Survivors of Ex-Vivo CD34+ Selected Allogeneic Hematopoietic Cell Transplantation Open
Introduction: Given limited prior data, we aimed to analyze all high-grade toxicities and associated risk factors after myeloablative conditioned (MAC) allo-HCT with ex-vivoCD34+ selection as GVHD prophylaxis. Methods: We retrospectively c…
View article: Comparable Survival with Organ Toxicity Predicting for Overall Survival (OS) and Non-Relapse Mortality (NRM) in Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HCT)
Comparable Survival with Organ Toxicity Predicting for Overall Survival (OS) and Non-Relapse Mortality (NRM) in Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HCT) Open
Introduction: Ex vivo CD 34 + selection prior to allo-HCT reduces GVHD without increasing relapse, but usually requires myeloablative conditioning. We aimed to identify toxicity patterns in older patients & the association with OS & NRM. M…
View article: Toxicities and Outcomes in the First Year after Ex-Vivo CD34+ Selected Allogeneic Hematopoietic Cell Transplantation in Adults with Hematologic Malignancies
Toxicities and Outcomes in the First Year after Ex-Vivo CD34+ Selected Allogeneic Hematopoietic Cell Transplantation in Adults with Hematologic Malignancies Open
Introduction: Ex-vivo CD34+ selected allogeneic hematopoietic cell transplantation (allo-HCT) after myeloablative conditioning (MAC) has been successfully utilized to reduce graft vs host disease (GVHD). However an analysis of the effects …
View article: Immune-Mediated Hemolytic Anemia (IMHA) and Immune Thrombocytopenia (ITP) after Ex-Vivo CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation
Immune-Mediated Hemolytic Anemia (IMHA) and Immune Thrombocytopenia (ITP) after Ex-Vivo CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation Open
Introduction: The incidence of IMHA and/or ITP (IMHA/ITP), patterns of treatment, and associated outcomes after myeloablative conditioned (MAC) allo-HCT using ex-vivoCD34+ selection as graft-versus-host disease (GVHD) prophylaxis have not …
View article: Recipient CMV Seropositivity & Viremia is Associated with the Development of Cord Blood (CB) Derived CD8 + Effectors & Effector Memory Cells in Adults Undergoing CB Transplantation (CBT)
Recipient CMV Seropositivity & Viremia is Associated with the Development of Cord Blood (CB) Derived CD8 + Effectors & Effector Memory Cells in Adults Undergoing CB Transplantation (CBT) Open
Introduction: CBT is characterized by lack of transferred immune memory, high rates of CMV reactivation in CMV + recipients & a relatively high incidence of aGVHD. How these factors impact T-cell reconstitution in adult CBT recipients is n…
View article: Fractionated Infusion of Hematopoietic Progenitor Cells (HPC) Does Not Improve Neutrophil Recovery or Survival in Patients Undergoing Allogeneic
Fractionated Infusion of Hematopoietic Progenitor Cells (HPC) Does Not Improve Neutrophil Recovery or Survival in Patients Undergoing Allogeneic Open
While HCT offers potentially curative therapy in patients (pts) with hematologic malignancies; treatment-related mortality (TRM) remains a concern. Strategies to improve post-HCT neutrophil recovery (NR) and immune reconstitution (IR) to d…