Taylor Davidson
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View article: An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor <i>in vitro</i> and <i>in vivo</i>
An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor <i>in vitro</i> and <i>in vivo</i> Open
Erythropoietin (EPO) initiates EPO receptor (EPOR) signaling in hematopoietic cells by binding to an asymmetric EPOR dimer through two different sites. We engineered dimeric diabody‐Fc (Db‐Fc) fusion proteins that appeared to act as potent…
View article: INITIAL COMMISSIONING EXPERIENCE WITH THE SPALLATION NEUTRON SOURCE VERTICAL TEST AREA RF SYSTEM
INITIAL COMMISSIONING EXPERIENCE WITH THE SPALLATION NEUTRON SOURCE VERTICAL TEST AREA RF SYSTEM Open
The Spallation Neutron Source (SNS) has developed a vertical test area (VTA) for the testing and qualification of superconducting radio frequency cavities. The associated RF System successfully supported the initial commissioning of the VT…
View article: Constitutive transgenic α-Klotho overexpression enhances resilience to and recovery from murine acute lung injury
Constitutive transgenic α-Klotho overexpression enhances resilience to and recovery from murine acute lung injury Open
Normal lungs do not express α-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related …
View article: In search of alternatively spliced alpha‐Klotho Kl1 protein in mouse brain
In search of alternatively spliced alpha‐Klotho Kl1 protein in mouse brain Open
Alpha‐Klotho is a multi‐functional protein essential for maintenance of a myriad of cell functions. αKlotho is a single transmembrane protein with a large extracellular segment consisting of two domains (termed Kl1 and Kl2) which is shed i…
View article: The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance
The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance Open
Aging‐related organ degeneration is driven by multiple factors including the cell maintenance mechanisms of autophagy, the cytoprotective protein αKlotho, and the lesser known effects of excess phosphate (Pi), or phosphotoxicity. To examin…
View article: Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis
Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis Open
Higher acid load to the kidney, resulting in higher urinary net acid excretion, is an important factor in the pathogenesis of idiopathic uric acid nephrolithiasis.