Taylor E. Gray
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View article: Synthesis of 4-azido sialic acid for testing against Siglec-7 and in metabolic oligosaccharide engineering
Synthesis of 4-azido sialic acid for testing against Siglec-7 and in metabolic oligosaccharide engineering Open
Peracetylated 4AzNeu5Ac is incorporated well into cell glycoconjugates. Deprotection via a thioglycoside facilitated chemoenzymatic synthesis of a C4-azido sialoside, which was studied for binding to Siglec-7 using native mass spectrometry.
View article: A kinetic trapping approach for facile access to 3FaxNeu5Ac and a photo-crosslinkable sialyltransferase probe
A kinetic trapping approach for facile access to 3FaxNeu5Ac and a photo-crosslinkable sialyltransferase probe Open
Sialic acid (Neu5Ac) is installed onto glycoconjugates by sialyltransferases (STs) using cytidine monophosphate-Neu5Ac (CMP-B-D-Neu5Ac) as their donor. The only class of cell-active ST inhibitors are those based on a 3FaxNeu5Ac scaffold, w…
View article: A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies
A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies Open
The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that can control cellular levels of protein fucosylation have consequently emerged as being of high interest. One area where inhibitors of fucosylation…
View article: Advances in understanding and exploiting Siglec–glycan interactions
Advances in understanding and exploiting Siglec–glycan interactions Open
Sialic-acid-binding immunoglobulin-type lectins (Siglecs) are a family of cell-surface immunomodulatory receptors that recognize sialic-acid-containing glycans. The majority of Siglecs have an inhibitory motif in their intercellular domain…
View article: Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR<sub>UB10712</sub>) of <i>Streptococcus gordonii</i>
Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR<sub>UB10712</sub>) of <i>Streptococcus gordonii</i> Open
Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the human oral cavity, but can also cause local or systemic diseases. Serine-rich repeat (SRR) glycoproteins exposed on the S. gordonii bacterial surface …
View article: Review of Cutaneous Repairs on the Hand and Fingers Following Dermatologic Surgery.
Review of Cutaneous Repairs on the Hand and Fingers Following Dermatologic Surgery. Open
Removal of cutaneous malignancies on the hand and fingers can result in challenging surgical defects to close. The dermatologic surgeon must not only be highly skilled, but also be knowledgeable regarding the complex anatomy of this area t…