Taylor Fuselier
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View article: Cytosolic Delivery of Bioactive Cyclic Peptide Cargo by Spontaneous Membrane Translocating Peptides
Cytosolic Delivery of Bioactive Cyclic Peptide Cargo by Spontaneous Membrane Translocating Peptides Open
Cyclic peptides that inhibit protein-protein interactions have significant advantages over linear peptides and small molecules for modulating cellular signaling networks in cancer and other diseases. However, the permeability barrier of th…
View article: Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes
Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes Open
We study the efficacy of a glucagon-like peptide-1 (GLP-1) and estrogen dual agonist (GLP1-E2) in pancreatic islet protection. GLP1-E2 provides superior protection from insulin-deficient diabetes induced by multiple low-dose streptozotocin…
View article: Efficacy of a Glucagon-Like Peptide-1 and Estrogen Dual Agonist in Pancreatic Islets Protection and Pre-Clinical Models of Insulin-Deficient Diabetes
Efficacy of a Glucagon-Like Peptide-1 and Estrogen Dual Agonist in Pancreatic Islets Protection and Pre-Clinical Models of Insulin-Deficient Diabetes Open
View article: Delivering the Cyclic Peptide Phalloidin to the Cell Cytosol by Membrane Translocating Carrier Peptides
Delivering the Cyclic Peptide Phalloidin to the Cell Cytosol by Membrane Translocating Carrier Peptides Open
View article: PHLD Class Proteins: A Family of New Players in the p53 Network
PHLD Class Proteins: A Family of New Players in the p53 Network Open
The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology …
View article: Crotonylation at serine 46 impairs p53 activity
Crotonylation at serine 46 impairs p53 activity Open
View article: Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes
Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes Open
Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stre…
View article: Use of Spontaneous Membrane Translocating Peptide for Cytosolic Delivery of Biologically Active Polar Peptide
Use of Spontaneous Membrane Translocating Peptide for Cytosolic Delivery of Biologically Active Polar Peptide Open
View article: Spontaneous Membrane Translocating Peptides: The Role of Leucine-Arginine Consensus Motifs
Spontaneous Membrane Translocating Peptides: The Role of Leucine-Arginine Consensus Motifs Open
View article: Spontaneous Membrane Translocating Peptides: Mechanisms and Motifs
Spontaneous Membrane Translocating Peptides: Mechanisms and Motifs Open
View article: The Delta Peptide of Ebola Virus has Potent Viroporin Activity
The Delta Peptide of Ebola Virus has Potent Viroporin Activity Open
View article: Optimizing a Spontaneous Membrane Translocating Peptide
Optimizing a Spontaneous Membrane Translocating Peptide Open
View article: Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity
Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity Open
To better understand the sequence-structure-function relationships that control the activity and selectivity of membrane-permeabilizing peptides, we screened a peptide library, based on the archetypal pore-former melittin, for loss-of-func…
View article: Mechanism Matters: A Taxonomy of Cell Penetrating Peptides
Mechanism Matters: A Taxonomy of Cell Penetrating Peptides Open