Taylor K. Paisie
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View article: Whole Genome Characterization of Leptospira kirschneri Serogroup Pomona in Croatia: Insights into Its Diversity and Evolutionary Emergence
Whole Genome Characterization of Leptospira kirschneri Serogroup Pomona in Croatia: Insights into Its Diversity and Evolutionary Emergence Open
Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira spp. with small rodents serving as the main reservoir. In Croatia, the serogroup Pomona has been detected most frequently, but its genomic diversity remains insufficient…
View article: Related Melioidosis Cases with Unknown Exposure Source, Georgia, USA, 1983–2024
Related Melioidosis Cases with Unknown Exposure Source, Georgia, USA, 1983–2024 Open
We identified 4 cases of presumptive autochthonous melioidosis during 1983-2024 in Georgia, USA. Epidemiologic investigation identified no recent international travel before illness; all cases were geographically linked, and 3 patients bec…
View article: The Brief Case: Human leptospirosis acquired in Minnesota and diagnosed using 16S ribosomal RNA gene PCR/next-generation sequencing of blood
The Brief Case: Human leptospirosis acquired in Minnesota and diagnosed using 16S ribosomal RNA gene PCR/next-generation sequencing of blood Open
View article: Investigating Anthrax-Associated Virulence Genes among Archival and Contemporary Bacillus cereus Group Genomes
Investigating Anthrax-Associated Virulence Genes among Archival and Contemporary Bacillus cereus Group Genomes Open
Bacillus anthracis causes anthrax through virulence factors encoded on two plasmids. However, non-B. anthracis organisms within the closely related, environmentally ubiquitous Bacillus cereus group (BCG) may cause an anthrax-like disease i…
View article: Seafood-Associated Outbreak of <i>ctx</i>-Negative <i>Vibrio mimicus</i> Causing Cholera-Like Illness, Florida, USA
Seafood-Associated Outbreak of <i>ctx</i>-Negative <i>Vibrio mimicus</i> Causing Cholera-Like Illness, Florida, USA Open
Vibrio mimicus caused a seafood-associated outbreak in Florida, USA, in which 4 of 6 case-patients were hospitalized; 1 required intensive care for severe diarrhea. Strains were ctx-negative but carried genes for other virulence determinan…
View article: Molecular Basis of the Toxigenic Vibrio cholerae O1 Serotype Switch from Ogawa to Inaba in Haiti
Molecular Basis of the Toxigenic Vibrio cholerae O1 Serotype Switch from Ogawa to Inaba in Haiti Open
Our phylodynamic analysis demonstrated that Vibrio cholerae Inaba strains in Haiti evolved directly from Ogawa strains. Our results support the hypothesis that after an initial Ogawa-dominated epidemic wave, V. cholerae Inaba was able to b…
View article: 322. Clinical-Grade Metagenomics in Urinary Tract Infections: Improving Performance of Next-Generation Sequencing Assays Using Internal Controls and Machine Learning
322. Clinical-Grade Metagenomics in Urinary Tract Infections: Improving Performance of Next-Generation Sequencing Assays Using Internal Controls and Machine Learning Open
Background Shotgun sequencing-based metagenomics is a useful approach to profiling microbiomes in environmental and patient samples. In a clinical setting, metagenomic techniques have the advantage of identifying organisms, which cannot be…
View article: Emergence and Evolutionary Response of <i>Vibrio cholerae</i> to Novel Bacteriophage, Democratic Republic of the Congo1
Emergence and Evolutionary Response of <i>Vibrio cholerae</i> to Novel Bacteriophage, Democratic Republic of the Congo1 Open
Cholera causes substantial illness and death in Africa. We analyzed 24 toxigenic Vibrio cholerae O1 strains isolated in 2015-2017 from patients in the Great Lakes region of the Democratic Republic of the Congo. Strains originating in south…
View article: Development of a Monoclonal Antibody to a Vibriophage as a Proxy for Vibrio cholerae Detection
Development of a Monoclonal Antibody to a Vibriophage as a Proxy for Vibrio cholerae Detection Open
Cholera is an acute watery, diarrheal disease that causes high rates of morbidity and mortality without treatment. Early detection of the etiologic agent of toxigenic Vibrio cholerae is important to mobilize treatment and mitigate outbreak…
View article: Development of a monoclonal antibody to a vibriophage as a proxy for<i>Vibrio cholerae</i>detection
Development of a monoclonal antibody to a vibriophage as a proxy for<i>Vibrio cholerae</i>detection Open
Cholera is an acute watery diarrheal disease that causes high rates of morbidity and mortality without treatment. Early detection of the etiologic agent of toxigenic Vibrio cholerae is important to mobilize treatment and mitigate outbreaks…
View article: Analysis of the Origin and Dissemination of HIV-1 Subtype C in Bulgaria
Analysis of the Origin and Dissemination of HIV-1 Subtype C in Bulgaria Open
HIV-1 subtype C is the most abundant strain of HIV-1 infections worldwide and was found in the first known patients diagnosed with HIV/AIDS in Bulgaria in 1986. However, there is limited information on the molecular-epidemiological charact…
View article: Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable
Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable Open
There is obvious interest in gaining insights into the epidemiology and evolution of the virus that has recently emerged in humans as the cause of the coronavirus disease 2019 (COVID-19) pandemic. The recent paper by Forster et al. (1), an…
View article: Toxigenic <i>Vibrio cholerae</i> evolution and establishment of reservoirs in aquatic ecosystems
Toxigenic <i>Vibrio cholerae</i> evolution and establishment of reservoirs in aquatic ecosystems Open
The spread of cholera in the midst of an epidemic is largely driven by direct transmission from person to person, although it is well-recognized that Vibrio cholerae is also capable of growth and long-term survival in aquatic ecosystems. W…
View article: UBASH3A Regulates the Synthesis and Dynamics of TCR–CD3 Complexes
UBASH3A Regulates the Synthesis and Dynamics of TCR–CD3 Complexes Open
The TCR–CD3 complex is a multicomponent membrane receptor, the expression of which is tightly regulated in thymocytes, as well as in mature T cells both at steady state and upon stimulation. In this study, we report novel roles for UBASH3A…
View article: Detection and phylogenetic characterization of arbovirus dual-infections among persons during a chikungunya fever outbreak, Haiti 2014
Detection and phylogenetic characterization of arbovirus dual-infections among persons during a chikungunya fever outbreak, Haiti 2014 Open
In the context of recent arbovirus epidemics, questions about the frequency of simultaneous infection of patients with different arbovirus species have been raised. In 2014, a major Chikungunya virus (CHIKV) epidemic impacted the Caribbean…
View article: Evidence for Mother-to-Child Transmission of Zika Virus Through Breast Milk
Evidence for Mother-to-Child Transmission of Zika Virus Through Breast Milk Open
Zikavirus (ZIKV) is an emerging viral pathogen that continues to spread throughout different regions of the world. Herein we report a case that provides further evidence that ZIKV transmission can occur through breastfeeding by providing a…
View article: UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor–Induced NF-κB Signaling
UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor–Induced NF-κB Signaling Open
Although over 40 type 1 diabetes (T1D) risk loci have been mapped in humans, the causative genes and variants for T1D are largely unknown. Here, we investigated a candidate gene in the 21q22.3 risk locus—UBASH3A, which is primarily express…
View article: Complete Genome Sequences of Identical <i>Zika virus</i> Isolates in a Nursing Mother and Her Infant
Complete Genome Sequences of Identical <i>Zika virus</i> Isolates in a Nursing Mother and Her Infant Open
Complete genome sequences were obtained for Zika viruses isolated from the breast milk of a Venezuelan patient and her child, who was exclusively breastfeeding at the time. These sequences are the first to be reported from a presumptive au…
View article: Detection of Alphacoronavirus vRNA in the Feces of Brazilian Free-Tailed Bats (Tadarida brasiliensis) from a Colony in Florida, USA
Detection of Alphacoronavirus vRNA in the Feces of Brazilian Free-Tailed Bats (Tadarida brasiliensis) from a Colony in Florida, USA Open
Bats are natural reservoirs of coronaviruses and other viruses with zoonotic potential. Florida has indigenous non-migratory populations of Brazilian free-tailed bats (Tadarida brasiliensis) that mostly roost in colonies in artificial stru…
View article: Zika and Chikungunya virus co-infection in a traveller returning from Colombia, 2016: virus isolation and genetic analysis
Zika and Chikungunya virus co-infection in a traveller returning from Colombia, 2016: virus isolation and genetic analysis Open
Introduction: Zika virus (ZIKV) and Chikungunya virus (CHIKV) can share the same mosquito vector, and co-infections by these viruses can occur in humans. While infections with these viruses share commonalities, CHIKV is unique in causing a…
View article: Mississippi River Plume Enriches Microbial Diversity in the Northern Gulf of Mexico
Mississippi River Plume Enriches Microbial Diversity in the Northern Gulf of Mexico Open
The Mississippi River (MR) serves as the primary source of freshwater and nutrients to the northern Gulf of Mexico (nGOM). Whether this input of freshwater also enriches microbial diversity as the MR plume migrates and mixes with the nGOM …
View article: Non-metric multidimensional scaling (NMDS) ordination of normalized 16S rRNA iTag sequence data.
Non-metric multidimensional scaling (NMDS) ordination of normalized 16S rRNA iTag sequence data. Open
(A) NMDS ordination of the first and third axes showing sample grouping based on the presence or absence of the protozoan predator. (B) NMDS ordination with those OTUs that were statistically significantly correlated with an axis and had a…