Taylor Lyons
YOU?
Author Swipe
View article: The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial
The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial Open
These results suggest that two high-dose sessions with psilocybin therapy are superior to a six-week daily course of a selective serotonin-reuptake inhibitor antidepressant, in remediating negative cognitive biases in depression.
View article: Enhanced meaning in life following psychedelic use: converging evidence from controlled and naturalistic studies
Enhanced meaning in life following psychedelic use: converging evidence from controlled and naturalistic studies Open
Introduction Psychedelics, such as psilocybin, are increasingly recognized for their propensity to elicit powerful subjective experiences that carry personal meaning. While research has demonstrated the capacity for these compounds to prom…
View article: The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial
The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial Open
Background Patients with Major Depressive Disorder (MDD) have more dysfunctional attitudes and pessimism than healthy individuals and these biases are correlated with depression severity. Psilocybin has demonstrated sustained remission in …
View article: An investigation of acute physiological and psychological moderators of psychedelic-induced personality change among healthy volunteers
An investigation of acute physiological and psychological moderators of psychedelic-induced personality change among healthy volunteers Open
This study investigated the effects of a single high-dose of psilocybin on personality traits in psychedelic-naïve healthy volunteers. These data originate from a larger within-subjects fixed-order design trial, where a single high dose of…
View article: Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits
Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits Open
Psilocybin has been shown to induce fast and sustained improvements in mental well-being across various populations, yet its long-term mechanisms of action are not fully understood. Initial evidence suggests that longitudinal functional an…
View article: Validation of the imperial psychedelic predictor scale
Validation of the imperial psychedelic predictor scale Open
Background Access to psychedelic drugs is liberalizing, yet responses are highly unpredictable. It is therefore imperative that we improve our ability to predict the nature of the acute psychedelic experience to improve safety and optimize…
View article: Validation of the Imperial Psychedelic Predictor Scale
Validation of the Imperial Psychedelic Predictor Scale Open
Access to psychedelic drugs is liberalizing, yet responses are highly unpredictable. It is therefore imperative that we improve our ability to predict the nature of the acute psychedelic experience to improve safety and optimize potential …
View article: Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging
Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging Open
(1) From mouse to man, shaking behavior (head twitches and/or wet dog shakes) is a reliable readout of psychedelic drug action. Shaking behavior like psychedelia is thought to be mediated by serotonin 2A receptors on cortical pyramidal cel…
View article: Body mass index (BMI) does not predict responses to psilocybin
Body mass index (BMI) does not predict responses to psilocybin Open
Background: Psilocybin is a serotonin type 2A (5-HT 2A ) receptor agonist and naturally occurring psychedelic. 5-HT 2A receptor density is known to be associated with body mass index (BMI), however, the impact of this on psilocybin therapy…
View article: From Relaxed Beliefs Under Psychedelics (REBUS) to Revised Beliefs After Psychedelics (REBAS): Preliminary Development of the RElaxed Beliefs Questionnaire (REB-Q)
From Relaxed Beliefs Under Psychedelics (REBUS) to Revised Beliefs After Psychedelics (REBAS): Preliminary Development of the RElaxed Beliefs Questionnaire (REB-Q) Open
Background: The Relaxed Beliefs Under pSychedelics (REBUS) model proposes that serotonergic psychedelics decrease the precision weighting of neurobiologically-encoded beliefs, and offers a unified account of the acute and therapeutic actio…
View article: Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience
Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience Open
Introduction: As their name suggests, ‘psychedelic’ (mind-revealing) compounds are thought to catalyse processes of psychological insight; however, few satisfactory scales exist to sample this. This study sought to develop a new scale to m…
View article: The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner
The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner Open
Background: Serotonin 2A receptors, the molecular target of psychedelics, are expressed by neuronal and vascular cells, both of which might contribute to brain haemodynamic characteristics for the psychedelic state. Aim: Aiming for a syste…
View article: More Realistic Forecasting of Future Life Events After Psilocybin for Treatment-Resistant Depression
More Realistic Forecasting of Future Life Events After Psilocybin for Treatment-Resistant Depression Open
Background: Evidence suggests that classical psychedelics can promote enduring changes in personality, attitudes and optimism, as well as improvements in mental health outcomes. Aim: To investigate the effects of a composite intervention, …
View article: Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice
Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice Open
The serotonin (5-HT) 2A receptor is the primary molecular target of serotonergic hallucinogens, which trigger large-scale perturbations of the cortex. Our understanding of how 5-HT2A activation may cause the effects of hallucinogens has be…
View article: Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression Open
Rationale: Previous research suggests that classical psychedelic compounds can induce lasting changes in personality traits, attitudes and beliefs in both healthy subjects and patient populations. Aim: Here we sought to investigate the eff…