Taylor M. Halsey
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View article: Expansion of a bacterial operon during cancer treatment ameliorates fluoropyrimidine toxicity
Expansion of a bacterial operon during cancer treatment ameliorates fluoropyrimidine toxicity Open
Dose-limiting toxicities remain a major barrier to drug development and therapy, revealing the limited predictive power of human genetics. Here, we demonstrate the utility of a more comprehensive approach to studying drug toxicity through …
View article: Figure S4 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S4 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Generation of reporter cells overexpressing CaSki cDNA library.
View article: Figure S3 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S3 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Tsyn-seq system spike-in assay.
View article: Supplementary Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Supplementary Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Supplementary Data
View article: Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Tools for genome-wide rapid identification of peptide–major histocompatibility complex targets of T-cell receptors (TCR) are not yet universally available. We present a new antigen screening method, the T-synapse (Tsyn) reporter system, wh…
View article: Figure S3 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S3 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Tsyn-seq system spike-in assay.
View article: Figure S1 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S1 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Activation of Fas-iNFκB reporter in FIR-APCs.
View article: Figure S2 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S2 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Aggregates of interacting target cells and T cells.
View article: Figure S2 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S2 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Aggregates of interacting target cells and T cells.
View article: Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Tools for genome-wide rapid identification of peptide–major histocompatibility complex targets of T-cell receptors (TCR) are not yet universally available. We present a new antigen screening method, the T-synapse (Tsyn) reporter system, wh…
View article: Figure S1 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S1 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Activation of Fas-iNFκB reporter in FIR-APCs.
View article: Supplementary Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Supplementary Data from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Supplementary Data
View article: Figure S4 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Figure S4 from Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Generation of reporter cells overexpressing CaSki cDNA library.
View article: Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform
Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform Open
Tools for genome-wide rapid identification of peptide–major histocompatibility complex targets of T-cell receptors (TCR) are not yet universally available. We present a new antigen screening method, the T-synapse (Tsyn) reporter system, wh…
View article: Microbiome alteration via fecal microbiota transplantation is effective for refractory immune checkpoint inhibitor–induced colitis
Microbiome alteration via fecal microbiota transplantation is effective for refractory immune checkpoint inhibitor–induced colitis Open
Immune checkpoint inhibitors (ICIs) target advanced malignancies with high efficacy but also predispose patients to immune-related adverse events like immune-mediated colitis (IMC). Given the association between gut bacteria with response …
View article: Bacteroides ovatus alleviates dysbiotic microbiota-induced intestinal graft-versus-host disease
Bacteroides ovatus alleviates dysbiotic microbiota-induced intestinal graft-versus-host disease Open
Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the intestinal microbiota is known to impact on its severity. However, an association between treatment …
View article: Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment Open
Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant ( n = 119), the fecal microbiome was characterized a…
View article: Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease Open
View article: Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease Open
View article: Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment Open
Not all cancer patients with severe neutropenia develop fever, and the fecal microbiome may play a role. In neutropenic hematopoietic cell transplant patients (n=119), 63 (53%) developed a subsequent fever and had increased fecal Akkermans…
View article: Uncovering the role of the gut microbiota in immune checkpoint blockade therapy: A mini-review
Uncovering the role of the gut microbiota in immune checkpoint blockade therapy: A mini-review Open