Taylor McElroy
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View article: Evaluating the Psychometrics of Accelerometer Data for Independent Monitoring of Task Repetitive Practice
Evaluating the Psychometrics of Accelerometer Data for Independent Monitoring of Task Repetitive Practice Open
Individuals post-stroke commonly experience impairments in upper extremity function that limit participation in valued activities. Task repetitive practice is an effective intervention strategy, but accurately monitoring adherence and move…
View article: 6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans
6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans Open
The synthetic antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6-PPD) is widely used in rubber products, but its toxicity in non-aquatic animals remains poorly understood. We investigated 6-PPD toxicity in mouse embryonic fi…
View article: Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans
Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans Open
Rising concerns about Bisphenol A (BPA) toxicity have prompted the search for safer alternatives. However, concerns persist regarding the safety of replacements like bisphenol TMC (BPTMC), a rapidly emerging BPA substitute. Utilizing the i…
View article: A Bibliometric Analysis of Research Examining How Space Radiation Affects Human and Rodent Cognition, 1990–2023
A Bibliometric Analysis of Research Examining How Space Radiation Affects Human and Rodent Cognition, 1990–2023 Open
The pursuit of exploring the outer space environment for biological research has been a topic of interest for nearly 60 years. The success of the next phase of space exploration depends on the ability to increase crew safety by identifying…
View article: ChatGPT’s Role in Gerontology Research
ChatGPT’s Role in Gerontology Research Open
Background Chat Generative Pre-trained Transformer (ChatGPT) and other ChatBots have emerged as tools for interacting with information in manners resembling natural human speech. Consequently, the technology is used across various discipli…
View article: Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode<i>Caenorhabditis elegans</i>
Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode<i>Caenorhabditis elegans</i> Open
Rising concerns about Bisphenol A (BPA) toxicity have prompted the search for safer alternatives. However, concerns persist regarding the safety of replacements like bisphenol TMC (BPTMC), a rapidly emerging BPA substitute. Utilizing the i…
View article: Reviewer #1 (Public Review): Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging
Reviewer #1 (Public Review): Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging Open
Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. H…
View article: Reviewer #3 (Public Review): Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging
Reviewer #3 (Public Review): Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging Open
Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. H…
View article: Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging
Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging Open
Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. H…
View article: Reviewer #2 (Public Review): Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging
Reviewer #2 (Public Review): Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging Open
Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. H…
View article: Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging
Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging Open
Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. H…
View article: Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging
Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging Open
Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. H…
View article: Iron homeostasis in older adults: balancing nutritional requirements and health risks
Iron homeostasis in older adults: balancing nutritional requirements and health risks Open
Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and also recycled from senescent red blood cells. Iron exists in two dietary forms: he…
View article: Sex differences in frailty among older adults
Sex differences in frailty among older adults Open
By definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vulnerability to stressors and shortens the time without disease (health span) while longevity refers to the length of l…
View article: Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior
Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior Open
Introduction Chemotherapy-induced cognitive impairment colloquially referred to as chemobrain is a poorly understood phenomenon affecting a highly variable proportion of patients with breast cancer. Here we investigate the association betw…
View article: Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance
Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance Open
Space exploration has advanced substantially over recent decades and plans to increase the duration of deep space missions are in preparation. One of the primary health concerns is potential damage to the central nervous system (CNS), resu…
View article: The role of mitochondria in the recovery of neurons after injury
The role of mitochondria in the recovery of neurons after injury Open
Mitochondria are well characterized by their fundamental functions in regulating cellular homeostasis, including energy and iron metabolism. These functions are essential in neurons with high metabolic demands and elongated neuronal proces…
View article: Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment
Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment Open
Advances in the early diagnosis and treatment have led to increases in breast cancer survivorship. Survivors report cognitive impairment symptoms such as loss of concentration and learning and memory deficits which significantly reduce the…
View article: Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue Open
This neural dissociation protocol (an adaptation of the protocol accompanying a commercial adult brain dissociation kit) optimizes tissue processing in preparation for detailed downstream analysis such as flow cytometry or single-cell sequ…
View article: Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells
Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells Open
Bisphenol A (BPA) is a chemical compound commonly used in the production of plastics for daily lives and industry. As BPA is well known for its adverse health effects, several alternative materials have been developed. This study comprehen…
View article: A Bibliometric Review of Artificial Extracellular Matrices Based on Tissue Engineering Technology Literature: 1990 through 2019
A Bibliometric Review of Artificial Extracellular Matrices Based on Tissue Engineering Technology Literature: 1990 through 2019 Open
Artificial extracellular matrices (aECMs) are an extension of biomaterials that were developed as in-vitro model environments for tissue cells that mimic the native in vivo target tissues’ structure. This bibliometric analysis evaluated th…
View article: Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis
Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis Open
The space extending beyond Earth's magnetosphere is subject to a complex field of high-energy charged nuclei, which are capable of traversing spacecraft shielding and human tissues, inducing dense ionization events. The central nervous sys…
View article: A Bibliometric Review of Publications on Oxidative Stress and Chemobrain: 1990–2019
A Bibliometric Review of Publications on Oxidative Stress and Chemobrain: 1990–2019 Open
Oxidative stress is considered one of the possible mechanisms behind chemobrain or the cognitive dysfunction persistent after chemotherapy treatment. Breast cancer patients have reported chemobrain symptoms since the 1990s. In this present…
View article: Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment
Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment Open
Background: Chemotherapy treatment for breast cancer can induce cognitive impairments often involving oxidative stress. The brain, as a whole, is susceptible to oxidative stress due to its high-energy requirements, limited anaerobic respir…
View article: Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model
Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model Open
Breast cancer (BC) is the most common cancer among women. Fortunately, BC survival rates have increased because the implementation of adjuvant chemotherapy leading to a growing population of survivors. However, chemotherapy-induced cogniti…
View article: Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats
Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats Open
Metaproteomics analysis of cecum contents of CKD rats with and without resistant starch supplementation reveals changes within gut microbiota at unprecedented resolution, providing both functional and taxonomic information. Proteins and or…
View article: Metaproteomics Reveals Potential Mechanisms by which Dietary Resistant Starch Supplementation Attenuates Chronic Kidney Disease Progression in Rats
Metaproteomics Reveals Potential Mechanisms by which Dietary Resistant Starch Supplementation Attenuates Chronic Kidney Disease Progression in Rats Open
Background Resistant starch is a prebiotic metabolized by the gut bacteria. It has been shown to attenuate chronic kidney disease (CKD) progression in rats. Previous studies employed taxonomic analysis using 16S rRNA sequencing and untarge…