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View article: Genetic diversity and regulatory features of human-specific <i>NOTCH2NL</i> duplications
Genetic diversity and regulatory features of human-specific <i>NOTCH2NL</i> duplications Open
SUMMARY NOTCH2NL ( NOTCH2 -N-terminus-like) genes arose from incomplete, recent chromosome 1 segmental duplications implicated in human brain cortical expansion. Genetic characterization of these loci and their regulation is complicated by…
View article: Conservation of dichromatin organization along regional centromeres
Conservation of dichromatin organization along regional centromeres Open
Summary The focal attachment of the kinetochore to the centromere is essential for genome maintenance, yet the highly repetitive nature of satellite regional centromeres, such as those in humans, limits our understanding of their chromatin…
View article: Single-molecule architecture and heterogeneity of human telomeric DNA and chromatin
Single-molecule architecture and heterogeneity of human telomeric DNA and chromatin Open
Telomeres are essential for linear genomes, yet their repetitive DNA content and somatic variability has hindered attempts to delineate their chromatin architectures. We performed single-molecule chromatin fiber sequencing (Fiber-seq) on h…