Thomas Walter
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View article: A clinically relevant morpho-molecular classification of lung neuroendocrine tumours
A clinically relevant morpho-molecular classification of lung neuroendocrine tumours Open
Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. We conducted multi-omic analyses on over 300 lung NETs includ…
View article: Response to systemic treatments and survival of fibrolamellar carcinomas: An AGEO-SFCE French multicenter retrospective cohort
Response to systemic treatments and survival of fibrolamellar carcinomas: An AGEO-SFCE French multicenter retrospective cohort Open
FLC have a poor prognosis; ATT show mild response rate. Further approaches and personalized medicine seem to be an unmet need for patients with FLC and new treatments should be urgently developed.
View article: <scp>PRRT</scp> plus holmium‐166‐<scp>SIRT</scp> (<scp>HEPAR PLuS</scp>) versus <scp>PRRT</scp>‐only in patients with metastatic neuroendocrine tumors: A propensity‐score matched analysis
<span>PRRT</span> plus holmium‐166‐<span>SIRT</span> (<span>HEPAR PLuS</span>) versus <span>PRRT</span>‐only in patients with metastatic neuroendocrine tumors: A propensity‐score matched analysis Open
Patients with bulky neuroendocrine liver metastases (NELM) undergoing PRRT with [ 177 Lu]Lu‐DOTATATE have a worse survival than patients with limited liver metastases. Previously, the safety and efficacy of additional selective internal ra…
View article: Basic science and translational implications of current knowledge on neuroendocrine tumors
Basic science and translational implications of current knowledge on neuroendocrine tumors Open
Neuroendocrine tumors (NETs) are a diverse group of malignancies that can occur in various organs, with a notable prevalence in the lungs and gastrointestinal tract, which are the focus of this Review. Although NETs are rare in individual …
View article: Cold snaring vs. standard forceps biopsy in sampling colorectal cancer: a comparative case report
Cold snaring vs. standard forceps biopsy in sampling colorectal cancer: a comparative case report Open
International audience
View article: Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits
Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits Open
The mesenteric extension of small neuroendocrine tumors is the surgical limiting factor because of the risk of postoperative short bowel syndrome due to superior mesenteric artery involvement. Recent pathological studies have shown that th…
View article: Interference With VIP to Distinguish Between Real and False VIPoma: National Study From the French Endocrine Tumors Group
Interference With VIP to Distinguish Between Real and False VIPoma: National Study From the French Endocrine Tumors Group Open
Background Vasoactive intestinal peptide (VIP)-secreting tumors (VIPomas) are digestive neuroendocrine tumors in which the hormonal secretion is life-threatening. Biological confirmation is obtained by demonstrating an elevation in plasma …
View article: Clinical management of typical and atypical carcinoids/neuroendocrine tumors in <scp>ENETS</scp> centres of excellence ( <scp>CoE</scp> ): Survey from the <scp>ENETS</scp> lung <scp>NET</scp> task force
Clinical management of typical and atypical carcinoids/neuroendocrine tumors in <span>ENETS</span> centres of excellence ( <span>CoE</span> ): Survey from the <span>ENETS</span> lung <span>NET</span> task force Open
Lung carcinoid tumours are neuroendocrine neoplasms originating from the bronchopulmonary tract's neuroendocrine cells, accounting for only 1%–3% of all lung cancers but 30% of all neuroendocrine tumours. The incidence of lung carcinoids, …
View article: Clinico-biological factors predicting the benefit of the LV5FU2 maintenance strategy as a first-line therapy in patients with metastatic pancreatic cancer
Clinico-biological factors predicting the benefit of the LV5FU2 maintenance strategy as a first-line therapy in patients with metastatic pancreatic cancer Open
Introduction Predictive markers of LV5FU2 maintenance benefit after first-line induction with FOLFIRINOX in patients with metastatic pancreatic cancer are necessary to select patients who will not be harmed by this strategy. Patients and M…
View article: CO10.1 - A randomization algorithm for phase II clinical trials design involving a hybrid-synthetic-control
CO10.1 - A randomization algorithm for phase II clinical trials design involving a hybrid-synthetic-control Open
Randomized controlled trials (RCTs) in oncology, especially in rare diseases, are often unfeasible for ethical, long recruitment periods and high cost reasons. In this setting, single-arm trials (SATs) are used, but inadequate for demonstr…
View article: Duodenal neuroendocrine tumor successfully removed by endoscopic submucosal dissection with adaptative traction device
Duodenal neuroendocrine tumor successfully removed by endoscopic submucosal dissection with adaptative traction device Open
International audience
View article: Survival of patients managed in France for duodenal neuroendocrine tumors (D-NET): a 20-year multicenter cohort study from the GTE group: a cohort study
Survival of patients managed in France for duodenal neuroendocrine tumors (D-NET): a 20-year multicenter cohort study from the GTE group: a cohort study Open
Introduction: Duodenal neuroendocrine tumours (D-NETs) have a low incidence; however, their diagnosis has been increasing. Features such as tumour location, size, type, histological grade, and stage were used to adapt the treatment to eith…
View article: Beyond MEN1, When to Think About MEN4? Retrospective Study on 5600 Patients in the French Population and Literature Review
Beyond MEN1, When to Think About MEN4? Retrospective Study on 5600 Patients in the French Population and Literature Review Open
Context Germline CDKN1B variants predispose patients to multiple endocrine neoplasia type 4 (MEN4), a rare MEN1-like syndrome, with <100 reported cases since its discovery in 2006. Although CDKN1B mutations are frequently suggested to expl…
View article: Self-supervised learning to predict intrahepatic cholangiocarcinoma transcriptomic classes on routine histology
Self-supervised learning to predict intrahepatic cholangiocarcinoma transcriptomic classes on routine histology Open
Objective The transcriptomic classification of intrahepatic cholangiocarcinomas (iCCA) has been recently refined from two to five classes, associated with pathological features, targetable genetic alterations and survival. Despite its prog…
View article: Outcome on Mesenteric Mass Response of Small-Intestinal Neuroendocrine Tumors Treated by<sup>177</sup>Lu-DOTATATE Peptide Receptor Radionuclide Therapy: The MesenLuth Study, a National Study from the French Group of Endocrine Tumors and Endocan-RENATEN Network
Outcome on Mesenteric Mass Response of Small-Intestinal Neuroendocrine Tumors Treated by<sup>177</sup>Lu-DOTATATE Peptide Receptor Radionuclide Therapy: The MesenLuth Study, a National Study from the French Group of Endocrine Tumors and Endocan-RENATEN Network Open
A mesenteric mass (MM), characterized by fibrotic reaction, is present in most small-intestinal neuroendocrine tumors (SI-NETs). 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) has shown its efficacy in patients with progressiv…
View article: Right Axillary Artery Cannulation for Veno-Arterial Extracorporeal Membrane Oxygenation in Postcardiotomy Patients: A Single-Center Experience
Right Axillary Artery Cannulation for Veno-Arterial Extracorporeal Membrane Oxygenation in Postcardiotomy Patients: A Single-Center Experience Open
Background and Objectives: To analyze the patient outcome and complication rate of axillary artery cannulation for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients who could not be weaned from cardiopulmonary bypass …
View article: Systematic Resection of the Visible Scar After Incomplete Endoscopic Resection of Rectal Neuroendocrine Tumors
Systematic Resection of the Visible Scar After Incomplete Endoscopic Resection of Rectal Neuroendocrine Tumors Open
INTRODUCTION: When initial resection of rectal neuroendocrine tumors (r-NETs) is not R0, persistence of local residue could lead to disease recurrence. This study aimed to evaluate the interest of systematic resection of non-R0 r-NET scars…
View article: High Tumor Uptake on<sup>18</sup>F-FDOPA PET/CT Indicates Poor Prognosis in Patients with Metastatic Midgut Neuroendocrine Tumors: A Study from the Groupe d’étude des Tumeurs Endocrines and ENDOCAN-RENATEN Network
High Tumor Uptake on<sup>18</sup>F-FDOPA PET/CT Indicates Poor Prognosis in Patients with Metastatic Midgut Neuroendocrine Tumors: A Study from the Groupe d’étude des Tumeurs Endocrines and ENDOCAN-RENATEN Network Open
PET/CT with 6-18F-fluoro-l-dopa (18F-FDOPA) has high diagnostic performance for midgut neuroendocrine tumors (NETs). We explored the prognostic role of 18F-FDOPA PET/CT uptake in metastatic midgut NETs. Methods: We included, in a test coho…
View article: Adjuvant chemotherapy benefit according to T and N stage in small bowel adenocarcinoma: a large retrospective multicenter study
Adjuvant chemotherapy benefit according to T and N stage in small bowel adenocarcinoma: a large retrospective multicenter study Open
Background Small bowel adenocarcinoma is a rare cancer, and the role of adjuvant chemotherapy for localized disease is still debated. Methods This retrospective multicenter study included all consecutive patients who underwent curative sur…