Explanipedia

Intranasal Mosaic H1N1 Live Attenuated Influenza Vaccine Elicits Broad Cross‐Reactive Immunity and Protection Against Group 1 and 2 Influenza A Viruses Open

Ximeng Ma, Qi Chen, Y. Cai, Chen Chen, Jian Lü , et al. · 2025

Influenza, a highly pathogenic infectious disease, causes nearly half a million deaths annually worldwide. Thus, effective vaccine‐based prevention and control are crucial. Although live attenuated influenza vaccines (LAIVs) can induce muc…

Development of a broad-spectrum nasal live attenuated influenza vaccine based on mosaic antigen design against influenza B viruses Open

Xue Han, Rui Ma, Ximeng Ma, Hongwei Chen, Tianyi Zhao , et al. · 2025

ABSTRACTInfluenza B virus (IBV) causes significant seasonal disease burden, and frequent antigenic drift limits the effectiveness of conventional vaccines. To address this, we designed mosaic haemagglutinin (HA) and neuraminidase (N…

Emergence of scaling in dockless bike-sharing systems for bike choice behavior Open

Ruiqi Li, Tian Bai, Ankang Luo, Yang Yu, Linyuan Lv , et al. · 2025

Dockless bike-sharing platforms, which offer better accessibility and flexibility for users, play an important role in the transition towards green transportation. However, unlocking their full potential requires a deeper understanding of …

Integrative study of the anti-hyperuricemic mechanism of mulberry leaf extract: network pharmacology and animal model validation Open

Mengwen Liu, Jing Shen, Tian Bai, Hui Xiao · 2025

Re-Examination Characterization and Screening of Stripe Rust Resistance Gene of Wheat TaPR1 Gene Family Based on the Transcriptome in Xinchun 32 Open

Ting-Ting Sun, Nan Yan, Qi Liu, Tian Bai, Haifeng Gao , et al. · 2025

Pathogenesis-related protein-1 (PR1) encodes a water-soluble protein produced in plants after pathogen infection or abiotic stimulation. It plays a crucial role in plant-induced resistance by attacking pathogens, degrading cell wall macrom…

Cooperative and Independent Functionality of tmRNA and SmpB in Aeromonas veronii: A Multifunctional Exploration Beyond Ribosome Rescue Open

Tian Bai, Juanjuan Li, Xue Chi, Hong Li, Yanqiong Tang , et al. · 2025

The trans-translation system, mediated by transfer-messenger RNA (tmRNA, encoded by the ssrA gene) and its partner protein SmpB, helps to release ribosomes stalled on defective mRNA and targets incomplete protein products for hydrolysis. K…

Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening Open

Hengrui Liu, Arie Zask, F. Forouhar, Sho Iketani, Alana D. N. Williams , et al. · 2025

Variants of SARS-CoV-2 have continued to emerge across the world and cause hundreds of deaths each week. Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies, additional anti-viral therapeutics wit…

Single-molecule contact switching <i>via</i> electro-inductive effects Open

Yali Zhang, Tian Bai, J. T. Ye, Lina Luo, Qiang Wan , et al. · 2025

The electro-inductive effect at a charged electrode surface can control the Lewis adduct formation and dissociation between BF 3 and the pyridine N of heterocycles, providing a new approach for reversible single-molecule contact switching.

Synthesis of hierarchical nano-Y zeolite supported Pt catalyst for efficient hydrocracking of Fischer–Tropsch wax to jet fuel Open

Fan Shao, Fengzhi Guo, Tian Bai, Zhen Xu, Han Yang , et al. · 2025

Amine-Free Synthesis of Silicalite-1 Zeolites by the Conventional Hydrothermal Route Open

Jinquan Tao, Jia Yi, Tian Bai, XI NAN XUE, Rong Yao , et al. · 2024

Conventional Hydrothermal Synthesis of Mfi Zeolite in Methanol System Open

Jinquan Tao, Jia Yi, Tian Bai, Fan Shao, Wenbin Huang , et al. · 2024

Amine-Free Synthesis of Silicalite-1 Zeolites With Abundant Defect Sites Open

Jinquan Tao, Qiang Wei, Jia Yi, Tian Bai, Wenbin Huang , et al. · 2024

CYP19A1 mediates severe SARS-CoV-2 disease outcome in males Open

Stephanie Stanelle‐Bertram, Sebastian Beck, Nancy Kouassi Mounogou, Berfin Schaumburg, Fabian Stoll , et al. · 2023

Mild and asymptomatic influenza B virus infection among unvaccinated pregnant persons: Implication for effectiveness of non-pharmaceutical intervention and vaccination to prevent influenza Open

Liling Chen, Min Z. Levine, Suizan Zhou, Tian Bai, Yuanyuan Pang , et al. · 2022

The incidence of influenza B infection in unvaccinated pregnant persons is under-estimated substantially. Non-pharmaceutical intervention may have suboptimal effectiveness in preventing influenza B transmission due to the less clinical man…

H7N9 avian influenza virus infection in men is associated with testosterone depletion Open

Tian Bai, Yongkun Chen, Sebastian Beck, Stephanie Stanelle‐Bertram, Nancy Kouassi Mounogou , et al. · 2022

Human infections with H7N9 avian influenza A virus that emerged in East China in 2013 and caused high morbidity rates were more frequently detected in men than in women over the last five epidemic waves. However, molecular markers associat…

Poultry to Human Passport: Cross-species Transmission of Zoonotic H7N9 Avian Influenza Virus to Humans Open

Yongkun Chen, Tian Bai, Yuelong Shu · 2022

Human infections with H7N9 avian influenza virus were first reported in the early spring of 2013, in the Yangtze-delta region of China. This virus subsequently caused five successive epidemic waves from 2013 to 2018 with highest reported c…

CYP19A1 mediated sex hormone metabolism promotes severe SARS-CoV-2 disease outcome in males. Open

Stephanie Stanelle‐Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Berfin Schaumburg, Fabian Stoll , et al. · 2021

Male sex belongs to one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that could affect sex dependent disease outcome are yet unknown. Here, we identified the CYP19A1 gene encoding for the testostero…

High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study Open

Maria Schroeder, Berfin Schaumburg, Zacharias Mueller, Ann Christin Parplys, Dominik Jarczak , et al. · 2021

Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone l…

High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study Open

Maria Schroeder, Berfin Schaumburg, Zacharias Mueller, Ann Christin Parplys, Dominik Jarczak , et al. · 2021

Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone l…

Novel susceptibility loci for A(H7N9) infection identified by next generation sequencing and functional analysis Open

Baihui Zhao, Yongkun Chen, Mo Li, Jianfang Zhou, Zheng Teng , et al. · 2020

Low testosterone and high cytokine levels correlate with lethal H7N9 infections in men: a retrospective cohort study from 98 H7N9 patients Open

Yongkun Chen, Tian Bai, Sebastian Beck, Stephanie Stanelle‐Bertram, Tao Chen , et al. · 2020

Summary Background Human infections with avian influenza A (H7N9) virus emerged in East China in March 2013. In contrast to seasonal influenza A viruses, H7N9 infections showed a strong sex bias. Over the five epidemic waves in China, ~70%…

Sex hormone and metabolic dysregulations are associated with critical illness in male Covid-19 patients Open

Maria Schroeder, Berfin Schaumburg, Zacharias Müller, Ann Christin Parplys, Dominik Jarczak , et al. · 2020

Summary Males develop more severe SARS-CoV-2 infection related disease outcome than females. Herein, sex hormones were repeatedly proposed to play an important role in Covid-19 pathophysiology and immunity. However, it is yet unclear wheth…

Testosterone Protects Against Severe Influenza by Reducing the Pro-Inflammatory Cytokine Response in the Murine Lung Open

Berfin Tuku, Stephanie Stanelle‐Bertram, Julie Sellau, Sebastian Beck, Tian Bai , et al. · 2020

Influenza A virus pathogenesis may differ between men and women. The 2009 H1N1 influenza pandemic resulted in more documented hospitalizations in women compared to men. In this study, we analyzed the impact of male sex hormones on pandemic…

Association between rs12252 and influenza susceptibility and severity: an updated meta-analysis Open

T. Chen, Min Xiao, H. J. Yang, Ya‐Qiong Chen, Tian Bai , et al. · 2018

In several lately published studies, the association between single-nucleotide polymorphism (SNP, rs12252) of IFITM3 and the risk of influenza is inconsistent. To further understand the association between the SNP of IFITM3 and the risk of…

C-Reactive Protein Mediating Immunopathological Lesions: A Potential Treatment Option for Severe Influenza A Diseases Open

Rongbao Gao, Lijie Wang, Tian Bai, Ye Zhang, Bo Hong , et al. · 2017

Severe influenza diseases with high mortality have been frequently reported, especially in those patients infected with avian influenza A (H5N1, H7N9 or H10N8) or during a pandemic. Respiratory distress, which is attributed to alveolar dam…

A comprehensive retrospective study of the seroprevalence of H9N2 avian influenza viruses in occupationally exposed populations in China Open

Xin Li, Tian Bai, Jianfang Zhou, Yongkun Chen, Xiaodan Li , et al. · 2017

The H9N2 avian influenza virus circulates worldwide, predominantly in poultry. Its increasing infectivity and adaptation in poultry and mammals have enhanced the possibility of human infection. However, H9N2 human cases are difficult to de…

Transmissibility of the Influenza Virus during Influenza Outbreaks and Related Asymptomatic Infection in Mainland China, 2005-2013 Open

Tao Chen, Tianmu Chen, Ruchun Liu, Cuiling Xu, Dayan Wang , et al. · 2016

We collected 2768 Influenza-like illness emergency public health incidents from April 1, 2005 to November 30, 2013reported in the Emergency Public Reporting System. After screening by strict inclusion and exclusion criteria, there were 613…

Sero‐epidemiologic study of influenza A(H7N9) infection among exposed populations, China 2013‐2014 Open

Nijuan Xiang, Tian Bai, Kai Kang, Hui Yuan, Suizan Zhou , et al. · 2016

Background The first human infections of novel avian influenza A(H7N9) virus were identified in China in March 2013. Sentinel surveillance systems and contact tracing may not identify mild and asymptomatic human infections of influenza A(H…

Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015 Open

Wenfei Zhu, Hong Zhang, Xingyu Xiang, Li-Li Zhong, Lei Yang , et al. · 2016

In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix …

Sustained live poultry market surveillance contributes to early warnings for human infection with avian influenza viruses Open

Shisong Fang, Tian Bai, Lei Yang, Xin Wang, Bo Peng , et al. · 2016

Sporadic human infections with the highly pathogenic avian influenza (HPAI) A (H5N6) virus have been reported in different provinces in China since April 2014. From June 2015 to January 2016, routine live poultry market (LPM) surveillance …

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