Ted B. Usdin
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Targeted gene transfer into developmentally defined cell populations of the primate brain Open
The primate brain possesses unique physiological and developmental features, yet its systematic investigation has been hampered by a paucity of transgenic germline models and tools. Here, we present a minimally invasive method to introduce…
Mesoscopic analysis of GABAergic marker expression in acetylcholine neurons in the whole mouse brain Open
In the central nervous system, acetylcholine (ACh) neurons coordinate neural network activity required for higher brain functions, such as attention, learning, and memory, as well as locomotion. Disturbances in cholinergic signaling have b…
View article: Targeted gene transfer into developmentally defined cell populations of the primate brain
Targeted gene transfer into developmentally defined cell populations of the primate brain Open
The primate brain possesses unique physiological and developmental features whose systematic investigation is hampered by a paucity of transgenic germline models and tools. Here, we present a minimally invasive method to introduce transgen…
View article: A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus
A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus Open
The mediodorsal thalamus (MD) and adjacent midline nuclei are important for cognition and mental illness, but their cellular composition is not well defined. Using single-nucleus and spatial transcriptomics, we identified a conserved excit…
Diet-Induced Obesity Induces Transcriptomic Changes in Neuroimmunometabolic-Related Genes in the Striatum and Olfactory Bulb Open
The incidence of obesity has markedly increased globally over the last several decades and is believed to be associated with the easier availability of energy-dense foods, including high-fat foods. The reinforcing hedonic properties of hig…
Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors Open
Dopamine release in striatal circuits, including the nucleus accumbens (NAc), tracks separable features of reward such as motivation and reinforcement. However, the cellular and circuit mechanisms by which dopamine receptors transform dopa…
View article: Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP
Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP Open
Neuropeptides may exert trophic effects during development, and then neurotransmitter roles in the developed nervous system. One way to associate peptide‐deficiency phenotypes with either role is first to assess potential phenotypes in so‐…
Parathyroid hormone receptors in GtoPdb v.2023.1 Open
The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [50]) are class B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHr…
Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2) Open
Tuberoinfundibular peptide of 39 residues (TIP39) acts via its endogenous class B G‐protein coupled receptorthe parathyroid hormone 2 receptor (PTH2R). Hence, it is also known as parathyroid hormone 2. The peptide is expressed in the brain…
View article: Incorporating the image formation process into deep learning improves network performance in deconvolution applications
Incorporating the image formation process into deep learning improves network performance in deconvolution applications Open
We present ‘Richardson-Lucy Network’ (RLN), a fast and lightweight deep learning method for 3D fluorescence microscopy deconvolution. RLN combines the traditional Richardson-Lucy iteration with a fully convolutional network structure, impr…
A thalamo-preoptic pathway promoting social touch Open
Summary Social touch is an important form of communication, it is still unknown how it is processed. Here, we discovered a functional role for a neuronal pathway projecting from the posterior intralaminar thalamic nucleus (PIL) to the medi…
Parathyroid hormone receptors in GtoPdb v.2021.3 Open
The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [49]) are class B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHr…
Parathyroid hormone receptors in GtoPdb v.2021.2 Open
The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [49]) are class B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHr…
Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover Open
Injury induces synaptic, circuit, and systems reorganization. After unilateral amputation or stroke, this functional loss disrupts the interhemispheric interaction between intact and deprived somatomotor cortices to recruit deprived cortex…
Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [47]) are family B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTH…
View article: Accelerating iterative deconvolution and multiview fusion by orders of magnitude
Accelerating iterative deconvolution and multiview fusion by orders of magnitude Open
We describe theoretical and practical advances in algorithm and software design, resulting in ten to several thousand-fold faster deconvolution and multiview fusion than previous methods. First, we adapt methods from medical imaging, showi…
A Thalamo-Hypothalamic Pathway That Activates Oxytocin Neurons in Social Contexts in Female Rats Open
Oxytocin is released from neurons in the paraventricular hypothalamic nucleus (PVN) in mothers upon suckling and during adult social interactions. However, neuronal pathways that activate oxytocin neurons in social contexts are not yet est…