Ted R. Mikuls
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View article: Malondialdehyde-acetaldehyde modified macromolecules and resulting autoantibodies in rheumatoid arthritis pathogenesis: a Systematic Literature Review
Malondialdehyde-acetaldehyde modified macromolecules and resulting autoantibodies in rheumatoid arthritis pathogenesis: a Systematic Literature Review Open
Objective Substantial progress has been made in understanding the involvement of malondialdehyde-acetaldehyde (MAA) adducts in rheumatoid arthritis (RA) pathogenesis. This systematic review synthesizes current evidence on the role of MAA-m…
View article: Mortality in US Veterans with Rheumatoid Arthritis Treated with Immune Checkpoint Inhibitors (ICIs)
Mortality in US Veterans with Rheumatoid Arthritis Treated with Immune Checkpoint Inhibitors (ICIs) Open
Objective : This investigation compared all‐cause and cause‐specific mortality in patients with and without rheumatoid arthritis (RA) in the Veterans Health Administration (VHA) following immune checkpoint inhibitor (ICI) cancer treatment.…
View article: Financial Distress and its Determinants in Rheumatoid Arthritis
Financial Distress and its Determinants in Rheumatoid Arthritis Open
Objective To quantify the degree of financial distress and identify its determinants in adults with rheumatoid arthritis (RA) given the frequent chronic use of expensive disease modifying therapies. Methods We identified adults enrolled in…
View article: Performance of an Idiopathic Pulmonary Fibrosis Derived Multibiomarker Panel for Rheumatoid Arthritis‐Associated Interstitial Lung Disease
Performance of an Idiopathic Pulmonary Fibrosis Derived Multibiomarker Panel for Rheumatoid Arthritis‐Associated Interstitial Lung Disease Open
Objective To assess whether a panel of peripheral blood biomarkers associated with idiopathic pulmonary fibrosis (IPF) is also associated with interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) utilizing three indep…
View article: A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis
A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis Open
Background Individuals with serum elevations of anti‐cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA …
View article: Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis
Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis Open
Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured usi…
View article: Improvements in Health‐Related Quality of Life With Treat‐to‐Target Urate‐Lowering Therapy in Gout: A Post Hoc Analysis of a Randomized Multicenter Trial
Improvements in Health‐Related Quality of Life With Treat‐to‐Target Urate‐Lowering Therapy in Gout: A Post Hoc Analysis of a Randomized Multicenter Trial Open
Objective Although treat‐to‐target urate‐lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health‐related quality of life (HRQoL). We assessed the impact of treat‐to‐target ULT on H…
View article: Heterogeneity of Rheumatoid Arthritis–Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations With Disease Outcomes
Heterogeneity of Rheumatoid Arthritis–Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations With Disease Outcomes Open
Objective We aimed to identify unique disease trajectories within rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) based on longitudinal forced vital capacity (FVC) values and their associated clinical outcomes. Methods W…
View article: Long‐Term Opioids in Gout: A Matched Cohort Study From the Veterans Health Administration
Long‐Term Opioids in Gout: A Matched Cohort Study From the Veterans Health Administration Open
Objective Though used frequently to treat flare, risk of long‐term opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be presc…
View article: Certolizumab Inhibits Radiographic Progression Even in Rheumatoid Arthritis Patients with High Rheumatoid Factor Levels: A Pooled, Post Hoc Analysis of Two Phase 3 Trials
Certolizumab Inhibits Radiographic Progression Even in Rheumatoid Arthritis Patients with High Rheumatoid Factor Levels: A Pooled, Post Hoc Analysis of Two Phase 3 Trials Open
Objectives To assess radiographic progression in certolizumab pegol (CZP)+methotrexate (MTX) vs placebo (PBO)+MTX-treated patients (pts) with rheumatoid arthritis (RA), stratified by rheumatoid factor (RF) level, in the C-EARLY ( NCT015197…
View article: Agreement of Administrative Pharmacy Dispensing With Self‐Reported Use of Oral Prednisone in <scp>US</scp> Veterans With Rheumatoid Arthritis
Agreement of Administrative Pharmacy Dispensing With Self‐Reported Use of Oral Prednisone in <span>US</span> Veterans With Rheumatoid Arthritis Open
Objective Administrative claims are used to evaluate oral glucocorticoid use in rheumatoid arthritis (RA), despite limited evidence to support accuracy. We aimed to evaluate the performance of claims‐based algorithms for glucocorticoid use…
View article: Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis
Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis Open
Background Lung disease is the most overrepresented cause of death in rheumatoid arthritis (RA). Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with a combination of airborne…
View article: Genetically-determined variation in CRP impacts disease activity assessment in rheumatoid arthritis
Genetically-determined variation in CRP impacts disease activity assessment in rheumatoid arthritis Open
Objectives In patients with RA, we evaluated a single-nucleotide variant previously associated with lower CRP to assess if this impacts clinical disease activity assessments including the disease activity score-28 with CRP (DAS28(CRP)). Me…
View article: Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease
Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease Open
Objective Rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize uniqu…
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View article: Lung‐delivered IL‐10 mitigates Lung inflammation induced by repeated endotoxin exposures in male mice
Lung‐delivered IL‐10 mitigates Lung inflammation induced by repeated endotoxin exposures in male mice Open
Therapies capable of resolving inflammatory lung disease resulting from high‐consequence occupational/environmental hazards are lacking. This study seeks to determine the therapeutic potential of direct lung‐delivered interleukin (IL)‐10 f…
View article: Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis
Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis Open
View article: Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease
Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease Open
Objective The aim of this study was to determine whether pollutants such as fire smoke–related particulate matter <2.5 μm (PM 2.5 ) are associated with incident rheumatoid arthritis (RA) and RA‐associated interstitial lung disease (RA‐ILD)…
View article: High Disease Activity is Associated with Incident Osteoporotic Fractures Among Veterans with Rheumatoid Arthritis
High Disease Activity is Associated with Incident Osteoporotic Fractures Among Veterans with Rheumatoid Arthritis Open
View article: Frailty Carries an Increased Risk of Death in Rheumatoid Arthritis
Frailty Carries an Increased Risk of Death in Rheumatoid Arthritis Open
View article: Citrullinated and malondialdehyde-acetaldehyde-modified fibrinogen activates macrophages and promotes profibrotic responses in human lung fibroblasts
Citrullinated and malondialdehyde-acetaldehyde-modified fibrinogen activates macrophages and promotes profibrotic responses in human lung fibroblasts Open
This report demonstrates that fibrinogen simultaneously harboring two common posttranslational modifications activates macrophages to secrete platelet-derived growth factor (PDGF)-BB and transforming growth factor (TGF)-β. Resulting cross …
View article: <i>MUC5B</i> promoter variant and survival in rheumatoid arthritis-associated interstitial lung disease
<i>MUC5B</i> promoter variant and survival in rheumatoid arthritis-associated interstitial lung disease Open
Objective The objective of this study was to investigate the association between the MUC5B rs35705950 promoter variant and survival in RA-associated interstitial lung disease (RA-ILD). Methods We studied participants in the Veteran Affairs…
View article: Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement and inflammation modulators
Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement and inflammation modulators Open
Urate-lowering treatment (ULT) to target with xanthine oxidase inhibitors (XOIs) paradoxically causes early increase in gouty arthritis flares. Because delayed reduction in flare burden is mechanistically unclear, we tested for ULT inflamm…
View article: Metabolic Syndrome, Adipokines, and Response to Advanced Therapies in Rheumatoid Arthritis
Metabolic Syndrome, Adipokines, and Response to Advanced Therapies in Rheumatoid Arthritis Open
Objective We determined if metabolic syndrome, its components, and adipokines (adiponectin, leptin, and fibroblast growth factor‐21) were associated with response to advanced therapies among patients with rheumatoid arthritis (RA). Methods…
View article: Impact of high rheumatoid factor levels on treatment outcomes with certolizumab pegol and adalimumab in patients with rheumatoid arthritis
Impact of high rheumatoid factor levels on treatment outcomes with certolizumab pegol and adalimumab in patients with rheumatoid arthritis Open
Objectives To assess the impact of baseline RF level on drug concentrations and efficacy of certolizumab pegol [CZP; TNF inhibitor (TNFi) without a crystallizable fragment (Fc)] and adalimumab (ADA; Fc-containing TNFi) in patients with RA.…
View article: The Risk of Lung Cancer in Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease
The Risk of Lung Cancer in Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease Open
Objective We aimed to evaluate lung cancer risk in patients with rheumatoid arthritis (RA) and RA‐interstitial lung disease (ILD). Methods We performed a retrospective, matched cohort study of RA and RA‐ILD within the Veterans Health Admin…
View article: Multi‐Autoantibody Testing Identifies Expansion of Reactivity to Targeted Antigens Before a Diagnosis of Rheumatoid Arthritis
Multi‐Autoantibody Testing Identifies Expansion of Reactivity to Targeted Antigens Before a Diagnosis of Rheumatoid Arthritis Open
Objective Rheumatoid arthritis (RA) has a “pre‐RA” period in which multiple autoantibodies, including antibodies to citrullinated (cit) proteins (ACPA), rheumatoid factor (RF), anti–peptidyl arginine deiminase (anti‐PAD), among others, hav…
View article: Associations between periodontitis and serum anti‐malondialdehyde–acetaldehyde antibody concentrations in rheumatoid arthritis: A case‐control study
Associations between periodontitis and serum anti‐malondialdehyde–acetaldehyde antibody concentrations in rheumatoid arthritis: A case‐control study Open
Background Malondialdehyde–acetaldehyde (MAA) adducts lead to generation of anti‐MAA autoantibodies and have been independently identified in inflamed periodontal and rheumatoid arthritis (RA) tissues. This study evaluates serum samples fr…
View article: Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement activation and inflammation modulators
Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement activation and inflammation modulators Open
Background Urate-lowering treatment (ULT) to target with xanthine oxidase inhibitors (XOIs) paradoxically causes early increase in gouty arthritis flares. Because delayed reduction in flare burden is mechanistically unclear, we tested for …
View article: Combined repetitive inhalant endotoxin and collagen-induced arthritis drives inflammatory lung disease and arthritis severity in a testosterone-dependent manner
Combined repetitive inhalant endotoxin and collagen-induced arthritis drives inflammatory lung disease and arthritis severity in a testosterone-dependent manner Open
Our study shows that testosterone acts as a key immunomodulatory hormone contributing to critical features rheumatoid arthritis-associated lung disease in the setting of airborne endotoxin (LPS) exposures in the setting of arthritis induct…