Edwin W. Taylor
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View article: Tissue-specific consequences of tag fusions on protein expression in transgenic mice
Tissue-specific consequences of tag fusions on protein expression in transgenic mice Open
Genetic fusion of protein tags is widely used to study protein functions in vivo . It is well known that tag fusion can cause unwanted changes in protein stability, but whether this is an inherent property of the tagged protein, or can be …
View article: Tissue-specific consequences of tag fusions on protein expression in transgenic mice
Tissue-specific consequences of tag fusions on protein expression in transgenic mice Open
Genetic fusion of protein tags is widely used to study protein functions in vivo . It is well known that tag fusion can cause unwanted changes in protein stability, but whether this is an inherent property of the tagged protein, or can be …
View article: Humanity's Last Exam
Humanity's Last Exam Open
Benchmarks are important tools for tracking the rapid advancements in large language model (LLM) capabilities. However, benchmarks are not keeping pace in difficulty: LLMs now achieve over 90\% accuracy on popular benchmarks like MMLU, lim…
View article: David (Dave) John Randall (1938–2024), Fellow of the Royal Society of Canada, Fellow of the Brazilian Academy of Science
David (Dave) John Randall (1938–2024), Fellow of the Royal Society of Canada, Fellow of the Brazilian Academy of Science Open
WOS:001330347700012
View article: Individual variation in sublethal tolerance of warming and hypoxia in the pacu Piaractus mesopotamicus: an investigation of correlations and dependence on intrinsic metabolic phenotype
Individual variation in sublethal tolerance of warming and hypoxia in the pacu Piaractus mesopotamicus: an investigation of correlations and dependence on intrinsic metabolic phenotype Open
We evaluated interindividual variation in traits of warming and hypoxia tolerance in a cohort ( n = 24) of juvenile pacu Piaractus mesopotamicus , acclimated to 26°C, to investigate whether individuals tolerant to warming were also toleran…
View article: Cooperative ligand binding to a double-stranded Ising lattice—Application to cofilin binding to actin filaments
Cooperative ligand binding to a double-stranded Ising lattice—Application to cofilin binding to actin filaments Open
Cooperative ligand binding to linear polymers is fundamental in many scientific disciplines, particularly biological and chemical physics and engineering. Such ligand binding interactions have been widely modeled using infinite one-dimensi…
View article: Tolerance of an acute warming challenge declines with body mass in Nile tilapia: evidence of a link to capacity for oxygen uptake
Tolerance of an acute warming challenge declines with body mass in Nile tilapia: evidence of a link to capacity for oxygen uptake Open
It has been proposed that larger individuals within fish species may be more sensitive to global warming, as a result of limitations in their capacity to provide oxygen for aerobic metabolic activities. This could affect size distributions…
View article: Tolerance of an acute warming challenge declines with body mass in Nile tilapia: evidence of a link to capacity for oxygen uptake
Tolerance of an acute warming challenge declines with body mass in Nile tilapia: evidence of a link to capacity for oxygen uptake Open
It is proposed that larger individuals within fish species may be more sensitive to global warming, due to limitations in their capacity to provide oxygen for aerobic metabolic activities. This could affect size distributions of population…
View article: Cholinergic regulation along the pulmonary arterial tree of the South American rattlesnake: vascular reactivity, muscarinic receptors, and vagal innervation
Cholinergic regulation along the pulmonary arterial tree of the South American rattlesnake: vascular reactivity, muscarinic receptors, and vagal innervation Open
Vascular tone in the reptilian pulmonary vasculature is primarily under cholinergic, muscarinic control exerted via the vagus nerve. This control has been ascribed to a sphincter located at the arterial outflow, but we speculated whether t…
View article: Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches
Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches Open
Significance Arp2/3 complex is an ATPase that binds to the side of a preexisting actin filament and nucleates an actin filament branch. Growing branched networks experience variable resistance and respond by adapting growth speed, power, a…
View article: Patient Outcomes at Twelve Months after Early Decompressive Craniectomy for Diffuse Traumatic Brain Injury in the Randomized DECRA Clinical Trial
Patient Outcomes at Twelve Months after Early Decompressive Craniectomy for Diffuse Traumatic Brain Injury in the Randomized DECRA Clinical Trial Open
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial of early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In the DECRA trial, patien…
View article: Evolutionary and cardio‐respiratory physiology of air‐breathing and amphibious fishes
Evolutionary and cardio‐respiratory physiology of air‐breathing and amphibious fishes Open
Air‐breathing and amphibious fishes are essential study organisms to shed insight into the required physiological shifts that supported the full transition from aquatic water‐breathing fishes to terrestrial air‐breathing tetrapods. While t…
View article: Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict?
Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict? Open
Striated muscle contraction occurs when myosin undergoes a lever-type structural change. This process (the power stroke) requires ATP and is governed by the thin filament, a complex of actin, tropomyosin, and troponin. The authors have use…
View article: Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish Open
Heart rate variation during air breathing indicates similarities between mammals and primitive lungfish.