Ted W. Simon
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View article: Can the Predictive Analytics Toolkit (PAT) handle a genomic data set?
Can the Predictive Analytics Toolkit (PAT) handle a genomic data set? Open
The Predictive Analytics Toolkit (PAT) was developed to facilitate use of new approach methodologies (NAMs) to predict health hazards and risks from chemicals. PAT is a user-friendly web application that integrates many R packages to enabl…
View article: Environmental Risk Assessment: A Toxicological Approach
Environmental Risk Assessment: A Toxicological Approach Open
"This book explains how environmental risk assessment in particular is of increasing importance as a means of seeking to address the potential effects of chemicals in the environment in both the developed and developing world"--
View article: The Predictive Analytics Toolkit (PAT): User-friendly predictive analytics for advancing new approach methodologies (NAMs)
The Predictive Analytics Toolkit (PAT): User-friendly predictive analytics for advancing new approach methodologies (NAMs) Open
Advanced test systems and knowledge of biology, how chemical exposures occur, and the mechanisms, pathways and dose-dependent changes that can lead to toxicity are rapidly catalyzing the transformation away from traditional approaches to n…
View article: Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals
Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals Open
Regulatory agencies across the world are facing the challenge of performing risk-based prioritization of thousands of chemicals in commerce. Here, we present an approach using the Threshold of Toxicological Concern (TTC) combined with heur…
View article: How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data?
How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data? Open
IARC has begun using ToxCast/Tox21 data in efforts to represent key characteristics of carcinogens to organize and weigh mechanistic evidence in cancer hazard determinations and this implicit inference approach also is being considered by …
View article: Bayesian methods for uncertainty factor application for derivation of reference values
Bayesian methods for uncertainty factor application for derivation of reference values Open
In 2014, the National Research Council (NRC) published Review of EPA's Integrated Risk Information System (IRIS) Process that considers methods EPA uses for developing toxicity criteria for non-carcinogens. These criteria are the Reference…
View article: Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study
Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study Open
Single point estimates of human health hazard/toxicity values such as a reference dose (RfD) are generally used in chemical hazard and risk assessment programs for assessing potential risks associated with site- or use-specific exposures. …
View article: The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor
The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor Open
An Adverse Outcome Pathway (AOP) represents the existing knowledge of a biological pathway leading from initial molecular interactions of a toxicant and progressing through a series of key events (KEs), culminating with an apical adverse o…
View article: A Model for Aryl Hydrocarbon Receptor-Activated Gene Expression Shows Potency and Efficacy Changes and Predicts Squelching Due to Competition for Transcription Co-Activators
A Model for Aryl Hydrocarbon Receptor-Activated Gene Expression Shows Potency and Efficacy Changes and Predicts Squelching Due to Competition for Transcription Co-Activators Open
A stochastic model of nuclear receptor-mediated transcription was developed based on activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and subsequent binding the activated AHR to xenobiotic respon…
View article: Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes
Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes Open
An adverse outcome pathway (AOP) describes the causal linkage between initial molecular events and an adverse outcome at individual or population levels. Whilst there has been considerable momentum in AOP development, far less attention ha…
View article: An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept
An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept Open
Rapid high throughput in vitro screening (HTS) assays are now available for characterizing dose-responses in assays that have been selected for their sensitivity in detecting estrogen-related endpoints. For example, EPA's ToxCast™ program …