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View article: #3520 Gene expression profiles of PBMCs in kidney vs. lung recipients prior to extracorporeal photopheresis: similarities and differences
#3520 Gene expression profiles of PBMCs in kidney vs. lung recipients prior to extracorporeal photopheresis: similarities and differences Open
Background and Aims Chronic allograft rejection of the kidney (CKR) and lung transplant (CLAD) represent major causes of mortality and graft loss, with limited therapeutic options currently available. Several centers are now adopting extra…
View article: #3701 Genetic insights delCFHR3-1 linked to <i>de novo</i> thrombotic microangiopathy in kidney transplant rfecipients
#3701 Genetic insights delCFHR3-1 linked to <i>de novo</i> thrombotic microangiopathy in kidney transplant rfecipients Open
Background and Aims The complement system's overactivation typically occurs during transplantation and in the post-transplant phase. Indeed, donor and recipient characteristics, various drugs (mTOR inhibitors, CNIs), viral infections and i…
View article: A Pre-Clinical Study on the Use of the Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor PEP 2-8 to Mitigate Ischemic Injury in a Rat Marginal Donor Model
A Pre-Clinical Study on the Use of the Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor PEP 2-8 to Mitigate Ischemic Injury in a Rat Marginal Donor Model Open
Proprotein Convertase Subtilisin/Kexin type 9 PCSK9 inhibitors (PCSK9i) are a novel class of cholesterol-lowering agents that also offer protection against tissue ischemia by reducing apoptosis, pyroptosis, and myocardial infarct size. Thi…
View article: Case Report: Extracorporeal photopheresis for BK virus nephropathy as a novel treatment for high-risk rejection kidney transplant recipient
Case Report: Extracorporeal photopheresis for BK virus nephropathy as a novel treatment for high-risk rejection kidney transplant recipient Open
Background BK virus-associated nephropathy (BKVAN) is a major complication in kidney transplantation caused by the reactivation of latent BK virus (BKV) under immunosuppression. BKVAN has been strongly associated with increased graft loss.…
View article: Engineered ATP-Loaded Extracellular Vesicles Derived from Mesenchymal Stromal Cells: A Novel Strategy to Counteract Cell ATP Depletion in an In Vitro Model
Engineered ATP-Loaded Extracellular Vesicles Derived from Mesenchymal Stromal Cells: A Novel Strategy to Counteract Cell ATP Depletion in an In Vitro Model Open
The use of adenosine triphosphate (ATP) has shown promising effects in alleviating ischemic damage across various tissues. However, the penetration of ATP into kidney tubular cells presents a challenge due to their unique anatomical and ph…
View article: Atypical Hemolytic Uremic Syndrome Associated with BNT162b2 mRNA COVID-19 Vaccine in a Kidney Transplant Recipient: A Case Report and Literature Review
Atypical Hemolytic Uremic Syndrome Associated with BNT162b2 mRNA COVID-19 Vaccine in a Kidney Transplant Recipient: A Case Report and Literature Review Open
Case Report: We report a case of a 37-year-old female with kidney transplant, who was admitted at our hospital due to worsening renal function, nephrotic proteinuria, and anemia developed 21 days after the second dose of BNT162b2 COVID-19 …
View article: #1446 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death
#1446 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death Open
Background and Aims PCSK9 inhibitors (PCSK9i) are a new class of cholesterol-lowering drugs that is gaining market share in treating hypercholesterolemia because of their effectiveness in lowering LDL cholesterol and cardiovascular risk, e…
View article: #1331 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death
#1331 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death Open
Background and Aims PCSK9 inhibitors (PCSK9i) are a new class of cholesterol-lowering drugs that is gaining market share in treating hypercholesterolemia because of their effectiveness in lowering LDL cholesterol and cardiovascular risk, e…
View article: #3232 ANTICOAGULANT RELATED NEPHROPATHY – AN UNDERDIAGNOSED COMPLICATION
#3232 ANTICOAGULANT RELATED NEPHROPATHY – AN UNDERDIAGNOSED COMPLICATION Open
Background and Aims Anticoagulant-related nephropathy (ARN) is an underdiagnosed complication of anticoagulant therapy (AT). Method We report 3 cases of ARN. Patient 1: 31 year-old male (M), kidney transplanted for reflux nephropathy, with…
View article: Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 Pneumonia
Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 Pneumonia Open
We report a preliminary experience of adjuvant therapy with Hemoperfusion (HP) in patients with Severe Acute Respiratory Syndrome-CoronaVirus 2 (SARS-CoV2) pneumonia. Currently, there are no approved treatments for CoronaVirus Disease 19 (…