Tegan M. Haslam
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View article: Complex sphingolipid metabolism impacts cell division and plasmodesmal development in the moss <i>Physcomitrium patens</i>
Complex sphingolipid metabolism impacts cell division and plasmodesmal development in the moss <i>Physcomitrium patens</i> Open
Developmental patterning and organ structure are elegantly simple in the moss Physcomitrium patens, which facilitates the cultivation and phenotypic characterization of severe mutant alleles. Essential membrane lipids, such as complex phos…
View article: Setaphyte VERY-LONG-CHAIN FATTY ACYL DESATURASES are desaturases that impact glycerolipid and sphingolipid metabolism
Setaphyte VERY-LONG-CHAIN FATTY ACYL DESATURASES are desaturases that impact glycerolipid and sphingolipid metabolism Open
Desaturases in plants are diverse. They vary in localization, source of reducing power, and substrate preference, accepting glycerolipids, long-chain bases, acyl-CoAs, and acyl-ACPs, in varying states of (un)saturation and chain length. Th…
View article: Identification of <scp>INOSITOL PHOSPHORYLCERAMIDE SYNTHASE</scp> 2 ( <scp>IPCS2</scp> ) as a new rate‐limiting component in Arabidopsis pathogen entry control
Identification of <span>INOSITOL PHOSPHORYLCERAMIDE SYNTHASE</span> 2 ( <span>IPCS2</span> ) as a new rate‐limiting component in Arabidopsis pathogen entry control Open
SUMMARY INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) is involved in the biosynthesis of complex sphingolipids at the trans ‐Golgi network (TGN). Here, we demonstrate a role of IPCS2 in penetration resistance against non‐adapted powdery m…
View article: Identification of INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) as a new rate-limiting component in Arabidopsis pathogen entry control
Identification of INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) as a new rate-limiting component in Arabidopsis pathogen entry control Open
INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) is involved in the biosynthesis of complex sphingolipids at the trans-Golgi network (TGN). Here, we demonstrate a role of IPCS2 in penetration resistance against non-adapted powdery mildew fun…
View article: Complex sphingolipids are essential for cell division and plasmodesmal development in the moss<i>Physcomitrium patens</i>
Complex sphingolipids are essential for cell division and plasmodesmal development in the moss<i>Physcomitrium patens</i> Open
Developmental patterning and organ structure are elegantly simple in the moss Physcomitrium patens . In molecular genetic studies, this facilitates both the cultivation of severe mutant alleles and their phenotypic characterization. Essent…
View article: Diverse <i>INOSITOL PHOSPHORYLCERAMIDE SYNTHASE</i> mutant alleles of <i>Physcomitrium patens</i> offer new insight into complex sphingolipid metabolism
Diverse <i>INOSITOL PHOSPHORYLCERAMIDE SYNTHASE</i> mutant alleles of <i>Physcomitrium patens</i> offer new insight into complex sphingolipid metabolism Open
Summary Sphingolipids are widespread, abundant, and essential lipids in plants and in other eukaryotes. Glycosyl inositol phosphorylceramides (GIPCs) are the most abundant class of plant sphingolipids, and are enriched in the plasma membra…
View article: Divergent evolution of the alcohol‐forming pathway of wax biosynthesis among bryophytes
Divergent evolution of the alcohol‐forming pathway of wax biosynthesis among bryophytes Open
Summary The plant cuticle is a hydrophobic barrier, which seals the epidermal surface of most aboveground organs. While the cuticle biosynthesis of angiosperms has been intensively studied, knowledge about its existence and composition in …
View article: Viable mutants of essential genes in<i>Physcomitrium patens</i>as tools for studying primary metabolic processes
Viable mutants of essential genes in<i>Physcomitrium patens</i>as tools for studying primary metabolic processes Open
Sphingolipids are essential components of plant cells, which have been notoriously difficult to study in part due to pleiotropic or lethal knock-out mutant phenotypes. By relying on alternative end-joining of double stranded breaks, we suc…
View article: Germacrene A Synthases for Sesquiterpene Lactone Biosynthesis Are Expressed in Vascular Parenchyma Cells Neighboring Laticifers in Lettuce
Germacrene A Synthases for Sesquiterpene Lactone Biosynthesis Are Expressed in Vascular Parenchyma Cells Neighboring Laticifers in Lettuce Open
Sesquiterpene lactone (STL) and natural rubber (NR) are characteristic isoprenoids in lettuce (Lactuca sativa). Both STL and NR co-accumulate in laticifers, pipe-like structures located along the vasculature. NR-biosynthetic genes are excl…
View article: Diversity in sphingolipid metabolism across land plants
Diversity in sphingolipid metabolism across land plants Open
Sphingolipids are essential metabolites found in all plant species. They are required for plasma membrane integrity, tolerance of and responses to biotic and abiotic stresses, and intracellular signalling. There is extensive diversity in t…
View article: Sphingolipid Δ4-desaturation is an important metabolic step for glycosylceramide formation in <i>Physcomitrium patens</i>
Sphingolipid Δ4-desaturation is an important metabolic step for glycosylceramide formation in <i>Physcomitrium patens</i> Open
Glycosylceramides are abundant membrane components in vascular plants and are associated with cell differentiation, organogenesis, and protein secretion. Long-chain base (LCB) Δ4-desaturation is an important structural feature for metaboli…
View article: Sphingolipid long‐chain base hydroxylation influences plant growth and callose deposition in <i>Physcomitrium patens</i>
Sphingolipid long‐chain base hydroxylation influences plant growth and callose deposition in <i>Physcomitrium patens</i> Open
Summary Sphingolipids are enriched in microdomains in the plant plasma membrane (PM). Hydroxyl groups in the characteristic long‐chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microd…
View article: Drought stress modulates cuticular wax composition of the grape berry
Drought stress modulates cuticular wax composition of the grape berry Open
Drought events are a major challenge for many horticultural crops, including grapes, which are often cultivated in dry and warm climates. It is not understood how the cuticle contributes to the grape berry response to water deficit (WD); f…
View article: ECERIFERUM11/C-TERMINAL DOMAIN PHOSPHATASE-LIKE2 Affects Secretory Trafficking
ECERIFERUM11/C-TERMINAL DOMAIN PHOSPHATASE-LIKE2 Affects Secretory Trafficking Open
Secretory trafficking is highly conserved in all eukaryotic cells and is required for secretion of proteins as well as extracellular matrix components. In plants, the export of cuticular waxes and various cell wall components relies on sec…
View article: The β-Ketoacyl-CoA Synthase HvKCS1, Encoded by Cer-zh, Plays a Key Role in Synthesis of Barley Leaf Wax and Germination of Barley Powdery Mildew
The β-Ketoacyl-CoA Synthase HvKCS1, Encoded by Cer-zh, Plays a Key Role in Synthesis of Barley Leaf Wax and Germination of Barley Powdery Mildew Open
The cuticle coats the primary aerial surfaces of land plants. It consists of cutin and waxes, which provide protection against desiccation, pathogens and herbivores. Acyl cuticular waxes are synthesized via elongase complexes that extend f…
View article: The Unique Role of the ECERIFERUM2-LIKE Clade of the BAHD Acyltransferase Superfamily in Cuticular Wax Metabolism
The Unique Role of the ECERIFERUM2-LIKE Clade of the BAHD Acyltransferase Superfamily in Cuticular Wax Metabolism Open
The elongation of very-long-chain fatty acids is a conserved process used for the production of many metabolites, including plant cuticular waxes. The elongation of precursors of the most abundant cuticular wax components of some plants, h…
View article: Arabidopsis ECERIFERUM2-LIKE proteins are components of the fatty acid elongation machinery required for the production of cuticular waxes
Arabidopsis ECERIFERUM2-LIKE proteins are components of the fatty acid elongation machinery required for the production of cuticular waxes Open
Very-long-chain fatty acids (VLCFAs) are essential molecules produced by all plant cells, and are precursors of diverse primary and specialized metabolites. VLCFAs are elongated by a fatty acid elongation (FAE) complex of four core enzymes…
View article: The putative phospholipase Lip2 counteracts oxidative damage and influences the virulence of <i>Ustilago maydis</i>
The putative phospholipase Lip2 counteracts oxidative damage and influences the virulence of <i>Ustilago maydis</i> Open
Summary Ustilago maydis is an obligate biotrophic fungal pathogen which causes common smut disease of corn. To proliferate in host tissue, U. maydis must gain access to nutrients and overcome plant defence responses, such as the production…
View article: ECERIFERUM2-LIKE Proteins Have Unique Biochemical and Physiological Functions in Very-Long-Chain Fatty Acid Elongation
ECERIFERUM2-LIKE Proteins Have Unique Biochemical and Physiological Functions in Very-Long-Chain Fatty Acid Elongation Open
The extension of very-long-chain fatty acids (VLCFAs) for the synthesis of specialized apoplastic lipids requires unique biochemical machinery. Condensing enzymes catalyze the first reaction in fatty acid elongation and determine the chain…